Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

Search, filter, and prioritize proteins.

Export view
5572 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4751 PA4920 NAD synthetase PA4920, nadE Experimental + AlphaFold
6.3.1.5
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004359Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH4+. +47 total
0.457 Hit 30.4% 8.60e-14
4752 PA2639 NADH:-quinone oxidoreductase subunit C/D nuoCD, PA2639, nuoD, nuoC AlphaFold
7.1.1.-
GO:0030964An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. +58 total
0.457 Hit 43.8% 2.80e-33
4753 PA1224 NAD(P)H dehydrogenase PA1224 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003955Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol.
0.457 Hit 65.0% 1.21e-09
4754 PA0887 acetyl-CoA synthetase acsA ColabFold –
GO:0016208Binding to AMP, adenosine monophosphate. GO:0003987Catalysis of the reaction: acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate. GO:0019427OBSOLETE. The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate.
0.457 Hit 54.0% 0.00e+00
4755 PA0542 hypothetical protein PA0542 AlphaFold – – 0.457 No Hit N/A —
4756 PA2394 pyoverdine biosynthesis protein PvdN pvdN, PA2394 Experimental + AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0031071Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. GO:0006534OBSOLETE. The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. +25 total
0.456 Hit 28.6% 2.16e-09
4757 PA3156 UDP-2-acetamido-3-amino-2, 3-dideoxy-D-glucuronate N-acetyltransferase wbpD, PA3156 AlphaFold
2.3.1.201
GO:0016407Catalysis of the transfer of an acetyl group to an acceptor molecule. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +47 total
0.455 No Hit N/A —
4758 PA2310 hypothetical protein PA2310 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872Binding to a metal ion. GO:0000908Catalysis of the reaction: 2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + succinate + sulfite. +25 total
0.455 No Hit N/A —
4759 PA1391 glycosyl transferase family protein PA1391 AlphaFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:1901135The chemical reactions and pathways involving carbohydrate derivative.
0.455 Hit 22.1% 2.83e-10
4760 PA0906 transcriptional regulator PA0906 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0001896A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation. GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. +25 total
0.455 No Hit N/A —
4761 PA5350 rubredoxin alkG2, rubA2, PA5350 Experimental + AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0005506Binding to an iron (Fe) ion. +25 total
0.454 No Hit N/A —
4762 PA5193 heat shock protein 33 yrfI ColabFold –
GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051082Binding to an unfolded protein.
0.454 No Hit N/A —
4763 PA5038 3-dehydroquinate synthase aroB, PA5038 AlphaFold
4.2.3.4
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003856Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate. GO:0046872Binding to a metal ion. +58 total
0.454 No Hit N/A —
4764 PA3850 hypothetical protein PA3850 AlphaFold – – 0.454 No Hit N/A —
4765 PA3169 methylthioribose-1-phosphate isomerase PA3169, mtnA AlphaFold
5.3.1.23
GO:0046523Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate. GO:0019509OBSOLETE. The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. GO:0044249OBSOLETE. The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. +14 total
0.454 Hit 43.7% 6.04e-78
4766 PA2222 hypothetical protein PA2222 Experimental + AlphaFold – – 0.454 No Hit N/A —
4767 PA1920 anaerobic ribonucleoside triphosphate reductase nrdD, PA1920 AlphaFold –
GO:0031250An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004748Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. +47 total
0.454 No Hit N/A —
4768 PA1186 hypothetical protein PA1186 AlphaFold –
GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water. GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
0.454 No Hit N/A —
4769 PA0716 hypothetical protein PA0716 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006302The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
0.454 No Hit N/A —
4770 PA0307 hypothetical protein PA0307 AlphaFold – – 0.454 No Hit N/A —
4771 PA5035 glutamate synthase subunit beta gltD, PA5035, gltD_2 AlphaFold –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
0.453 Hit 31.2% 2.11e-12
4772 PA4956 thiosulfate:cyanide sulfurtransferase PA4956, rhdA AlphaFold
2.8.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004792Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+. GO:0009636Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
0.453 Hit 36.5% 3.15e-06
4773 PA1585 2-oxoglutarate dehydrogenase subunit E1 sucA, PA1585 AlphaFold
1.2.4.2
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0045252A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. GO:0004591Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H+ = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2. +47 total
0.453 Hit 46.4% 8.70e-43
4774 PA4983 two-component response regulator PA4983, aruR AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +58 total
0.452 No Hit N/A —
4775 PA4748 triosephosphate isomerase PA4748, tpiA AlphaFold
5.3.1.1
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004807Catalysis of the reaction: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate. GO:0006094The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. +36 total
0.452 Hit 49.1% 6.55e-30
Page of 223 · 5572 total proteins