Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4801 PA2744 threonine--tRNA ligase thrS, PA2744 AlphaFold
6.1.1.3
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. +811 total
0.445 Hit 40.8% 1.64e-84
4802 PA2285 hypothetical protein PA2285 AlphaFold – – 0.445 No Hit N/A —
4803 PA0381 thiazole synthase thiG, PA0381 Experimental + AlphaFold
2.8.1.10
GO:1902508A protein complex which is capable of 2-iminoacetate synthase activity. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990107Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H+ + 2 H2O. +25 total
0.445 No Hit N/A —
4804 PA1527 hypothetical protein smc, PA1527 AlphaFold –
GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +811 total
0.444 Hit 32.7% 3.33e-21
4805 PA1516 hypothetical protein PA1516 AlphaFold
4.1.1.97
GO:0005777A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. GO:0051997Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2. GO:0000255The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism. +25 total
0.444 Hit 34.8% 2.13e-26
4806 PA0795 methylcitrate synthase PA0795, prpC Experimental + AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0050440Catalysis of the reaction: H2O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H+. GO:0036440Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA. +47 total
0.444 Hit 23.6% 4.89e-17
4807 PA4270 DNA-directed RNA polymerase subunit beta rpoB, PA4270 AlphaFold
2.7.7.6
GO:0000428A protein complex that possesses DNA-directed RNA polymerase activity. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003899Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. +25 total
0.443 Hit 42.4% 2.17e-08
4808 PA4082 adhesive protein CupB5 PA4082, cupB5 AlphaFold –
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
0.443 No Hit N/A —
4809 PA3246 pseudouridine synthase PA3246, rluA AlphaFold
5.4.99.28 5.4.99.29
GO:0160142Catalysis of the reaction: uridine(746) in 23S rRNA = pseudouridine(746) in 23S rRNA. GO:0009982Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. GO:0003723Binding to an RNA molecule or a portion thereof. +58 total
0.443 Hit 36.1% 6.35e-07
4810 PA2887 citronellol catabolism dehydrogenase atuB, PA2887 Experimental + AlphaFold
1.3.1.38
GO:0019166Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
0.443 Hit 50.0% 1.69e-06
4811 PA2064 copper resistance protein B pcoB, PA2064 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0005507Binding to a copper (Cu) ion. GO:0006878A homeostatic process involved in the maintenance of a steady state level of copper ions within a cell.
0.443 No Hit N/A —
4812 PA1944 hypothetical protein PA1944 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. +14 total
0.443 No Hit N/A —
4813 PA1073 branched-chain amino acid ABC transporter permease BraD PA1073, braD AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015188Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid. GO:0015190Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid. +1114 total
0.443 No Hit N/A —
4814 PA5565 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA mnmG, gidA, PA5565 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0030488The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. +25 total
0.442 Hit 78.9% 6.71e-06
4815 PA5110 fructose-1,6-bisphosphatase PA5110, fbp AlphaFold
3.1.3.11
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0042132Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. +710 total
0.442 Hit 41.2% 1.29e-78
4816 PA2722 hypothetical protein PA2722 Experimental + AlphaFold –
GO:0016846Catalysis of the elimination of hydrogen sulfide or substituted H2S. GO:0046872Binding to a metal ion.
0.442 No Hit N/A —
4817 PA1288 hypothetical protein PA1288 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015483Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
0.442 No Hit N/A —
4818 PA5266 hypothetical protein PA5266 AlphaFold –
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0033104A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence. GO:0033103The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
0.441 No Hit N/A —
4819 PA0168 hypothetical protein PA0168 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0043168Binding to an anion, a charged atom or group of atoms with a net negative charge. GO:0032561Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. +25 total
0.441 No Hit N/A —
4820 PA5360 two-component response regulator PhoB phoB, PA5360 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +811 total
0.44 No Hit N/A —
4821 PA5183a hypothetical protein ColabFold –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006109Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. GO:0006402The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
0.44 No Hit N/A —
4822 PA1025 porin PA1025 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
0.44 No Hit N/A —
4823 PA1413 transcriptional regulator PA1413 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.439 No Hit N/A —
4824 PA4237 50S ribosomal protein L17 PA4237, rplQ AlphaFold –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
0.438 Hit 34.0% 9.17e-09
4825 PA2627 high frequency lysogenization protein HflD hflD, PA2627 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.438 No Hit N/A —
Page of 223 · 5572 total proteins