Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5176 PA0428 ATP-dependent RNA helicase rhlE, PA0428 AlphaFold
3.6.4.13
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +69 total
0.296 Hit 54.7% 1.52e-18
5177 PA3935 taurine dioxygenase tauD, PA3935 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872Binding to a metal ion. GO:0000908Catalysis of the reaction: 2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + succinate + sulfite. +25 total
0.295 No Hit N/A —
5178 PA3298 hypothetical protein PA3298 AlphaFold – – 0.295 No Hit N/A —
5179 PA4721 sugar fermentation stimulation protein A sfsA, PA4721 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.294 No Hit N/A —
5180 PA2813 glutathione S-transferase PA2813 AlphaFold
2.5.1.18
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0043295Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine. GO:0004364Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+.
0.294 Hit 30.3% 9.69e-10
5181 PA2742 50S ribosomal protein L35 rpmI, PA2742 AlphaFold –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
0.294 No Hit N/A —
5182 PA1409 acetylpolyamine aminohydrolase PA1409, aphA AlphaFold
3.5.1.- 3.5.1.62
GO:0047609Catalysis of the reaction: N-acetylputrescine + H2O = acetate + putrescine. GO:0004407Removal of an acetyl group from a lysine residue in a histone. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +36 total
0.293 Hit 38.0% 5.13e-11
5183 PA5453 GDP-mannose 4,6-dehydratase PA5453, gca, gmd Experimental + AlphaFold
4.2.1.47
GO:0008446Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H2O. GO:0070401Binding to the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. GO:0042351The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271). +47 total
0.292 Hit 48.2% 5.06e-110
5184 PA2702 hypothetical protein PA2702, tse2 Experimental + AlphaFold –
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
0.292 No Hit N/A —
5185 PA2931 CifR protein PA2931, cifR Experimental + AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0001217A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. +25 total
0.291 No Hit N/A —
5186 PA2827 methionine sulfoxide reductase B msrB, PA2827 AlphaFold
1.8.4.12
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0033743Catalysis of the reaction: L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol. GO:0008270Binding to a zinc ion (Zn). +58 total
0.291 Hit 57.9% 2.16e-49
5187 PA1269 transcriptional regulator PA1269 AlphaFold –
GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.291 No Hit N/A —
5188 PA1168 hypothetical protein PA1168 AlphaFold – – 0.291 No Hit N/A —
5189 PA2364 hypothetical protein PA2364 AlphaFold – – 0.289 No Hit N/A —
5190 PA3792 2-isopropylmalate synthase leuA, PA3792 AlphaFold
2.3.3.13
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003852Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+. GO:0003985Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA. +58 total
0.288 No Hit N/A —
5191 PA3633 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase ygbP ColabFold –
GO:0008299The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0070567Catalysis of the transfer of a cytidylyl group to an acceptor. +14 total
0.288 Hit 25.2% 1.65e-10
5192 PA2515 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase PA2515, xylL AlphaFold –
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0030497The elongation of a fatty acid chain by the sequential addition of two-carbon units. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.287 Hit 37.3% 1.16e-09
5193 PA1309 transcriptional regulator PA1309 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.287 No Hit N/A —
5194 PA0910 hypothetical protein PA0910 AlphaFold –
GO:0001896A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation. GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
0.286 No Hit N/A —
5195 PA0164 gamma-glutamyltranspeptidase PA0164 AlphaFold – – 0.286 Hit 33.1% 8.41e-13
5196 PA0133 HTH-type transcriptional activator BauR bauR, PA0133 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0009896Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. +14 total
0.285 No Hit N/A —
5197 PA4544 pseudouridine synthase rluD, PA4544 AlphaFold
5.4.99.23
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0160140Catalysis of the reaction: uridine(1911/1915/1917) in 23S rRNA = pseudouridine(1911/1915/1917) in 23S rRNA. GO:0009982Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. +47 total
0.284 Hit 31.0% 1.76e-13
5198 PA3371 hypothetical protein PA3371 AlphaFold – – 0.284 No Hit N/A —
5199 PA1214 hypothetical protein PA1214 AlphaFold
6.3.5.4
GO:0004066Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006529OBSOLETE. The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid.
0.284 Hit 27.8% 2.91e-08
5200 PA1167 hypothetical protein PA1167 Experimental + AlphaFold – – 0.284 No Hit N/A —
Page of 223 · 5572 total proteins