Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5226 PA2868 hypothetical protein PA2868 AlphaFold – – 0.268 No Hit N/A —
5227 PA2025 glutathione reductase PA2025, gor AlphaFold
1.8.1.7
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0004362Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+. +47 total
0.268 Hit 49.0% 4.49e-19
5228 PA4139 hypothetical protein PA4139 AlphaFold – – 0.266 No Hit N/A —
5229 PA3011 DNA topoisomerase I PA3011, topA AlphaFold
5.6.2.1
GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003917Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. +47 total
0.266 Hit 27.7% 1.82e-34
5230 PA4125 5-carboxymethyl-2-hydroxymuconate isomerase hpcD, PA4125 AlphaFold –
GO:0008704Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate. GO:0019439OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
0.264 No Hit N/A —
5231 PA1061 hypothetical protein cds1, PA1061 AlphaFold
4.4.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004124Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. +36 total
0.263 Hit 25.6% 3.15e-19
5232 PA4433 50S ribosomal protein L13 PA4433, rplM AlphaFold –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0003729Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. +36 total
0.262 Hit 35.9% 3.22e-19
5233 PA5321 deoxyuridine 5'-triphosphate nucleotidohydrolase PA5321, dut AlphaFold
3.6.1.23
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004170Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate. GO:0000287Binding to a magnesium (Mg) ion. +25 total
0.261 Hit 35.4% 5.32e-12
5234 PA4274 50S ribosomal protein L11 rplK, PA4274 AlphaFold –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0070180Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +25 total
0.261 Hit 46.6% 2.45e-12
5235 PA0300 putrescine ABC transporter substrate-binding protein SpuD PA0300, spuD Experimental + AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0019810Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. GO:0019809Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. +47 total
0.261 No Hit N/A —
5236 PA5190 nitroreductase PA5190 AlphaFold –
GO:0003955Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.26 No Hit N/A —
5237 PA0654 S-adenosylmethionine decarboxylase speD, PA0654 AlphaFold
4.1.1.50
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004014Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2. GO:0008295The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.
0.26 No Hit N/A —
5238 PA1254 dihydrodipicolinate synthetase PA1254 AlphaFold –
GO:0047425Catalysis of the reaction: 4-hydroxy-1-pyrroline-2-carboxylate + H2O + H+ = 2,5-dioxopentanoate + NH4. GO:0008840Catalysis of the reaction: L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+. GO:0019470The chemical reactions and pathways resulting in the breakdown of trans-4-hydroxy-L-proline. +14 total
0.259 Hit 28.0% 4.03e-19
5239 PA1588 succinyl-CoA ligase subunit beta PA1588, sucC AlphaFold
6.2.1.5
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0042709A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +912 total
0.258 Hit 48.4% 2.23e-12
5240 PA4432 30S ribosomal protein S9 PA4432, rpsI AlphaFold –
GO:0022627The small subunit of a ribosome located in the cytosol. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +25 total
0.257 Hit 39.8% 4.59e-07
5241 PA2999 Na(+)-translocating NADH-quinone reductase subunit A nqrA, PA2999 AlphaFold
7.2.1.1
GO:0016655Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.257 No Hit N/A —
5242 PA0511 heme d1 biosynthesis protein NirJ nirJ, PA0511 AlphaFold –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0046872Binding to a metal ion. +25 total
0.257 No Hit N/A —
5243 PA2260 hypothetical protein kguE, PA2260 Experimental + AlphaFold – – 0.256 No Hit N/A —
5244 PA1795 cysteine--tRNA ligase PA1795, cysS AlphaFold
6.1.1.16
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +69 total
0.256 Hit 53.6% 2.54e-23
5245 PA1165 4'-phosphopantetheinyl transferase pcpS, PA1165 Experimental + AlphaFold –
GO:0009366A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway. GO:0008897Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. GO:0000287Binding to a magnesium (Mg) ion. +47 total
0.256 No Hit N/A —
5246 PA4244 50S ribosomal protein L15 rplO, PA4244 AlphaFold –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0019843Binding to a ribosomal RNA. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +36 total
0.255 No Hit N/A —
5247 PA0761 L-aspartate oxidase nadB, PA0761 AlphaFold
1.4.3.16
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008734Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + H2O2. Can also use fumatate as electron acceptor under anaerobic conditions, yielding succinate. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +36 total
0.255 Hit 34.0% 1.04e-60
5248 PA3001 glyceraldehyde-3-phosphate dehydrogenase PA3001 AlphaFold
1.2.1.-
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. +14 total
0.254 Hit 41.9% 4.80e-48
5249 PA1244 hypothetical protein PA1244 Experimental + AlphaFold – – 0.253 No Hit N/A —
5250 PA1019a thioesterase ColabFold – – 0.253 No Hit N/A —
Page of 223 · 5572 total proteins