Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5151 PA4370 insulin-cleaving metalloproteinase outer membrane protein PA4370, icmP Experimental + AlphaFold –
GO:0030313An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. GO:0046872Binding to a metal ion.
0.307 No Hit N/A —
5152 PA2036 hypothetical protein PA2036 AlphaFold –
GO:0008757Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule.
0.307 No Hit N/A —
5153 PA0726 hypothetical protein PA0726 AlphaFold – – 0.307 No Hit N/A —
5154 PA2017 hypothetical protein PA2017 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.305 No Hit N/A —
5155 PA4766 hypothetical protein PA4766 AlphaFold – – 0.304 No Hit N/A —
5156 PA2151 alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase PA2151, glgE AlphaFold
2.4.99.16
GO:0004556Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units. GO:0016758Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). GO:0030979The chemical reactions and pathways resulting in the formation of alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds. +47 total
0.304 No Hit N/A —
5157 PA3213 hypothetical protein PA3213 AlphaFold – – 0.303 No Hit N/A —
5158 PA2511 transcriptional regulator PA2511 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
0.303 No Hit N/A —
5159 PA2379 oxidoreductase PA2379 AlphaFold –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
0.303 Hit 34.1% 6.01e-11
5160 PA1333 hypothetical protein PA1333 AlphaFold – – 0.303 No Hit N/A —
5161 PA0316 D-3-phosphoglycerate dehydrogenase serA, PA0316 AlphaFold
1.1.1.399 1.1.1.95
GO:0047545Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0004617Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. +25 total
0.303 Hit 39.1% 1.25e-09
5162 PA5167 C4-dicarboxylate-binding protein dctP, PA5167 Experimental + AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0015740The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.302 No Hit N/A —
5163 PA3819 hypothetical protein PA3819 AlphaFold –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:1900190Any process that modulates the frequency, rate or extent of single-species biofilm formation.
0.302 No Hit N/A —
5164 PA0714 hypothetical protein PA0714 AlphaFold – – 0.302 No Hit N/A —
5165 PA5136 hypothetical protein PA5136 AlphaFold –
GO:0005515Binding to a protein.
0.301 No Hit N/A —
5166 PA2405 hypothetical protein PA2405 AlphaFold – – 0.3 No Hit N/A —
5167 PA2141 hypothetical protein PA2141 AlphaFold – – 0.3 No Hit N/A —
5168 PA2585 excinuclease ABC subunit C PA2585, uvrC AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009380Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +69 total
0.299 No Hit N/A —
5169 PA0677 HxcW pseudopilin PA0677 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.
0.299 No Hit N/A —
5170 PA4463 hypothetical protein PA4463 AlphaFold –
GO:0022627The small subunit of a ribosome located in the cytosol. GO:0043024Binding to a small ribosomal subunit. GO:0045900Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation. +14 total
0.298 No Hit N/A —
5171 PA1081 flagellar basal body rod protein FlgF flgF, PA1081 AlphaFold –
GO:0009288A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0030694The central portion of the bacterial-type flagellar basal body, which spans the periplasm and threads through the rings. GO:0071978Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria. +14 total
0.298 No Hit N/A —
5172 PA2337 transcriptional regulator MtlR mtlR, PA2337 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0009893Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. +25 total
0.297 No Hit N/A —
5173 PA0571 hypothetical protein PA0571 AlphaFold – – 0.297 No Hit N/A —
5174 PA4564 hypothetical protein PA4564 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.296 No Hit N/A —
5175 PA0973 peptidoglycan associated lipoprotein OprL PA0973, pal, oprL AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.296 No Hit N/A —
Page of 223 · 5572 total proteins