Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5201 PA4240 30S ribosomal protein S11 PA4240, rpsK AlphaFold –
GO:0022627The small subunit of a ribosome located in the cytosol. GO:0019843Binding to a ribosomal RNA. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +25 total
0.283 Hit 47.3% 7.22e-22
5202 PA1355 hypothetical protein PA1355 AlphaFold – – 0.282 No Hit N/A —
5203 PA5233 flagellar basal body protein FliL PA5233 AlphaFold –
GO:0009425One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071978Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria. +25 total
0.281 No Hit N/A —
5204 PA4041 hypothetical protein PA4041 AlphaFold –
GO:0047808Catalysis of the reaction: D-tartrate = H2O + oxaloacetate. GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0046872Binding to a metal ion. +14 total
0.281 No Hit N/A —
5205 PA1845 hypothetical protein tsi1, PA1845 Experimental + AlphaFold – – 0.281 No Hit N/A —
5206 PA2191 adenylate cyclase exoY, PA2191 Experimental + AlphaFold –
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0008294Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin.
0.28 No Hit N/A —
5207 PA0061 hypothetical protein PA0061 AlphaFold – – 0.28 No Hit N/A —
5208 PA4394 hypothetical protein PA4394 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008381Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
0.279 No Hit N/A —
5209 PA0593 4-hydroxythreonine-4-phosphate dehydrogenase PA0593, pdxA Experimental + AlphaFold
1.1.1.262
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0050570Catalysis of the reaction: 4-(phosphooxy)-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH. GO:0050897Binding to a cobalt ion (Co2+). +58 total
0.279 No Hit N/A —
5210 PA4671 50S ribosomal protein L25/general stress protein Ctc PA4671, ctc, rplY AlphaFold –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0008097Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +25 total
0.278 No Hit N/A —
5211 PA3087 hypothetical protein PA3087 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.278 No Hit N/A —
5212 PA3812 iron-binding protein IscA PA3812, iscA AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. +47 total
0.277 Hit 54.8% 7.10e-08
5213 PA3100 type II secretion system protein H PA3100, xcpU, pddB AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0071978Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria. +25 total
0.277 No Hit N/A —
5214 PA0449 acyl-CoA thioesterase PA0449 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0052816Catalysis of the reaction: a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. +36 total
0.277 No Hit N/A —
5215 PA3817 methyltransferase PA3817, trmJ AlphaFold
2.1.1.200
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0106339Catalysis of the reaction: cytidine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32) in tRNA + S-adenosyl-L-homocysteine + H+. +47 total
0.276 No Hit N/A —
5216 PA2142 short-chain dehydrogenase PA2142 AlphaFold –
GO:0016614Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.276 Hit 46.7% 4.39e-08
5217 PA1508 hypothetical protein PA1508 AlphaFold – – 0.276 No Hit N/A —
5218 PA4442 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase cysNC, cysN, PA4442 AlphaFold –
GO:0004020Catalysis of the reaction: adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H+. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005525Binding to GTP, guanosine triphosphate. +69 total
0.275 Hit 39.4% 2.44e-27
5219 PA3159 UDP-N-acetyl-d-glucosamine 6-dehydrogenase wbpA, PA3159 AlphaFold
1.1.1.136
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0003954Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. +710 total
0.275 Hit 22.8% 3.17e-13
5220 PA4773 hypothetical protein speH, PA4773 AlphaFold
4.1.1.50
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004014Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2. GO:0008295The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.
0.274 No Hit N/A —
5221 PA2991 soluble pyridine nucleotide transhydrogenase PA2991, sthA, sth AlphaFold
1.6.1.1
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004148Catalysis of the reaction: N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD+ = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H+. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +47 total
0.273 Hit 42.9% 6.46e-07
5222 PA4667 hypothetical protein PA4667 Experimental + AlphaFold –
GO:0005515Binding to a protein.
0.272 Hit 24.5% 5.25e-10
5223 PA3180 hypothetical protein PA3180 AlphaFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.271 No Hit N/A —
5224 PA1464 purine-binding chemotaxis protein cheW_3, PA1464, cheW AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
0.27 No Hit N/A —
5225 PA3451 hypothetical protein PA3451 AlphaFold – – 0.269 No Hit N/A —
Page of 223 · 5572 total proteins