Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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701 / 5572 proteins Structure: Experimental

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Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
626 PA3825 hypothetical protein PA3825 Experimental + AlphaFold DB model
3.1.4.52
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+. GO:0046872Binding to a metal ion. +25 total
No map 0.403 No Hit N/A —
627 PA4279 pantothenate kinase PA4279, coaA, coaX Experimental + AlphaFold DB model
2.7.1.33
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. +36 total
No map 0.402 No Hit N/A —
628 PA3053 hydrolase PA3053 Experimental + AlphaFold DB model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
No map 0.402 Hit 40.2% 2.87e-10
629 PA2657 two-component response regulator PA2657, carR Experimental + AlphaFold DB model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +58 total
No map 0.399 No Hit N/A —
630 PA1606 hypothetical protein PA1606 Experimental + AlphaFold DB model – – No map 0.396 No Hit N/A —
631 PA0355 protease PfpI PA0355, pfpI Experimental + AlphaFold DB model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019172Catalysis of the reaction: methylglyoxal + H2O = D-lactate. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. +69 total
No map 0.393 Hit 28.6% 5.30e-11
632 PA0425 multidrug resistance protein MexA PA0425, mexA Experimental + AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0042802Binding to an identical protein or proteins. +710 total
No map 0.392 No Hit N/A —
633 PA1481 cytochrome c-type biogenesis protein CcmG ccmG, PA1481, dsbE Experimental + AlphaFold DB model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015036Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. +25 total
No map 0.391 No Hit N/A —
634 PA0397 cation efflux system protein PA0397 Experimental + AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872Binding to a metal ion. GO:0005385Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. +58 total
No map 0.391 Hit 43.2% 7.32e-20
635 PA3158 UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase wlbA, PA3158, wbpB Experimental + AlphaFold DB model
1.1.1.335
GO:0070403Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. GO:0070404Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. GO:0003954Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. +912 total
No map 0.387 No Hit N/A —
636 PA4483 aspartyl/glutamyl-tRNA amidotransferase subunit A gatA, PA4483 Experimental + AlphaFold DB model
6.3.5.7
GO:0030956A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0050567Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP. +25 total
No map 0.381 Hit 42.4% 7.98e-57
637 PA4204 gluconolactonase PpgL PA4204, ppgL Experimental + AlphaFold DB model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0017057Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H+. GO:0006006The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. +14 total
No map 0.378 No Hit N/A —
638 PA4781 cyclic di-GMP phosphodiesterase PA4781 Experimental + AlphaFold DB model
3.1.4.-
GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+. GO:0004112Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. GO:0046872Binding to a metal ion. +47 total
No map 0.376 No Hit N/A —
639 PA4945 tRNA delta(2)-isopentenylpyrophosphate transferase PA4945, miaA Experimental + AlphaFold DB model
2.5.1.75
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0052381Catalysis of the reaction: adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate. GO:0006400The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. +14 total
No map 0.373 Hit 37.4% 5.24e-16
640 PA3546 alginate biosynthesis protein AlgX PA3546, algX Experimental + AlphaFold DB model
2.3.1.-
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0042121The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). +14 total
No map 0.373 No Hit N/A —
641 PA4899 aldehyde dehydrogenase PA4899 Experimental + AlphaFold DB model –
GO:0018479Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.37 Hit 40.9% 9.76e-18
642 PA2723 hypothetical protein PA2723 Experimental + AlphaFold DB model –
GO:0046872Binding to a metal ion.
No map 0.369 No Hit N/A —
643 PA2666 6-carboxytetrahydropterin synthase QueD PA2666 Experimental + AlphaFold DB model
4.-.-.-
GO:0070497Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+. GO:0046872Binding to a metal ion. GO:0008616The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in position 34 of tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon.
No map 0.367 Hit 30.8% 3.16e-15
644 PA5010 UDP-glucose:(heptosyl) LPS alpha 1,3-glucosyltransferase WaaG waaG, PA5010 Experimental + AlphaFold DB model –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.
No map 0.366 No Hit N/A —
645 PA1690 translocation protein in type III secretion pscU, PA1690 Experimental + AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009306The controlled release of proteins from a cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.364 No Hit N/A —
646 PA4179 porin PA4179 Experimental + AlphaFold DB model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
No map 0.36 No Hit N/A —
647 PA1268 4-hydroxyproline 2-epimerase PA1268 Experimental + AlphaFold DB model
5.1.1.8
GO:0047580Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline.
No map 0.36 Hit 30.7% 2.29e-33
648 PA4764 ferric uptake regulation protein fur, PA4764 Experimental + AlphaFold DB model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +811 total
No map 0.359 No Hit N/A —
649 PA1375 erythronate-4-phosphate dehydrogenase PA1375, pdxB Experimental + AlphaFold DB model
1.1.1.290
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0033711Catalysis of the reaction: 4-phospho-D-erythronate + NAD+ = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H+ + NADH. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. +58 total
No map 0.358 Hit 34.1% 1.55e-12
650 PA5013 branched-chain amino acid aminotransferase ilvE, PA5013 Experimental + AlphaFold DB model
2.6.1.42
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004084Catalysis of the reaction: a branched-chain amino acid (L-leucine, L-isoleucine and L-valine) + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. GO:0052656Catalysis of the reaction: L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate. +811 total
No map 0.357 Hit 26.0% 5.64e-12
Page of 29 · 701 total proteins