Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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701 / 5572 proteins Structure: Experimental

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Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
101 PA0212 malonate decarboxylase subunit gamma mdcE, PA0212 Experimental + AlphaFold DB model –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
No map 0.882 No Hit N/A —
102 PA0211 malonate decarboxylase subunit beta PA0211, mdcD Experimental + AlphaFold DB model –
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +14 total
No map 0.882 Hit 28.6% 2.08e-06
103 PA0616 hypothetical protein PA0616, VR2 Experimental + AlphaFold DB model – – No map 0.881 No Hit N/A —
104 PA3547 alginate lyase PA3547, algL Experimental + AlphaFold DB model
4.2.2.3
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0045135Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends. GO:0004794Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH4. +36 total
No map 0.88 No Hit N/A —
105 PA1910 ferric-mycobactin receptor FemA femA, PA1910 Experimental + AlphaFold DB model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0015344Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). +710 total
No map 0.88 No Hit N/A —
106 PA4026 acetyltransferase PA4026 Experimental + AlphaFold DB model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.879 No Hit N/A —
107 PA2567 hypothetical protein PA2567 Experimental + AlphaFold DB model
3.1.4.52
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+. GO:1900190Any process that modulates the frequency, rate or extent of single-species biofilm formation. +14 total
No map 0.879 No Hit N/A —
108 PA4991 hypothetical protein PA4991 Experimental + AlphaFold DB model
1.-.-.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.878 No Hit N/A —
109 PA1374 hypothetical protein PA1374 Experimental + AlphaFold DB model –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.878 No Hit N/A —
110 PA1353 hypothetical protein PA1353 Experimental + AlphaFold DB model – – No map 0.878 No Hit N/A —
111 PA0998 hypothetical protein pqsC, PA0998 Experimental + AlphaFold DB model
2.3.1.230
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. +25 total
No map 0.878 No Hit N/A —
112 PA0997 hypothetical protein PA0997, pqsB Experimental + AlphaFold DB model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0044550The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.
No map 0.878 No Hit N/A —
113 PA0093 hypothetical protein tse6, PA0093 Experimental + AlphaFold DB model
3.2.2.5
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0003953Catalysis of the reaction: NAD+ + H2O = ADP-D-ribose + nicotinamide + H+. GO:0050135Catalysis of the reaction: NADP+ + H2O = ADP-D-ribose 2'-phosphate + nicotinamide + H+. +25 total
No map 0.878 No Hit N/A —
114 PA0092 hypothetical protein tsi6, PA0092 Experimental + AlphaFold DB model –
GO:0097351Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. GO:0033103The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
No map 0.878 No Hit N/A —
115 PA0740 SDS hydrolase SdsA1 sdsA1, PA0740 Experimental + AlphaFold DB model
3.1.6.21
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0042802Binding to an identical protein or proteins. GO:0018741Catalysis of the reaction: a primary linear alkyl sulfate ester + H2O = a primary alcohol + H+ + sulfate. +36 total
No map 0.877 No Hit N/A —
116 PA4066 hypothetical protein PA4066 Experimental + AlphaFold DB model – – No map 0.876 No Hit N/A —
117 PA4511 hypothetical protein pxpA3, PA4511 Experimental + AlphaFold DB model
3.5.2.9
GO:0017168Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + 2 H+ + phosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
No map 0.875 No Hit N/A —
118 PA5026 hypothetical protein PA5026 Experimental + AlphaFold DB model – – No map 0.874 No Hit N/A —
119 PA4190 monooxygenase pqsL, PA4190 Experimental + AlphaFold DB model –
GO:0008688Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O. GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0019622The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate.
No map 0.874 Hit 26.1% 1.07e-08
120 PA1622 hydrolase PA1622 Experimental + AlphaFold DB model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.873 Hit 44.0% 5.93e-21
121 PA1003 transcriptional regulator MvfR PA1003, mvfR Experimental + AlphaFold DB model –
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +36 total
No map 0.873 No Hit N/A —
122 PA5173 carbamate kinase PA5173, arcC Experimental + AlphaFold DB model
2.7.2.2
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008804Catalysis of the reaction: hydrogencarbonate + NH4+ + ATP = carbamoyl phosphate + ADP + H2O + H+. +25 total
No map 0.872 No Hit N/A —
123 PA0527 transcriptional regulator Dnr dnr, PA0527 Experimental + AlphaFold DB model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0001216A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. +69 total
No map 0.872 No Hit N/A —
124 PA0288 guanidinopropionase PA0288, gpuA Experimental + AlphaFold DB model
3.5.3.17
GO:0008783Catalysis of the reaction: agmatine + H2O = putrescine + urea. GO:0047972Catalysis of the reaction: 3-guanidinopropanoate + H2O = beta-alanine + urea. GO:0046872Binding to a metal ion. +25 total
No map 0.872 Hit 46.6% 1.33e-95
125 PA3326 ATP-dependent Clp protease proteolytic subunit clpP2, PA3326 Experimental + AlphaFold DB model
3.4.21.92
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009368A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form. GO:0004176Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. +47 total
No map 0.871 Hit 39.5% 1.03e-36
Page of 29 · 701 total proteins