Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1976 PA0257 hypothetical protein PA0257 AlphaFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.803 No Hit N/A —
1977 PA0026 phospholipase C plcB, PA0026 AlphaFold –
GO:0016298Catalysis of the hydrolysis of a lipid. GO:0004629A glycerophospholipase activity that cleaves the first phosphodiester bond between the phosphate and glycerol, producing a mono- or a diacylglycerol, depending on whether the substrate is a lysoglycerophospholipid or a glycerophospholipid. GO:0008270Binding to a zinc ion (Zn). +47 total
0.803 No Hit N/A —
1978 PA5421 glutathione-independent formaldehyde dehydrogenase PA5421, fdhA AlphaFold
1.2.1.46
GO:0140087Catalysis of the reaction: acetaldehyde + NAD+ + H2O = acetate + NADH + 2 H+. GO:0018467Catalysis of the reaction: formaldehyde + H2O + NAD+ = formate + 2 H+ + NADH. GO:0008270Binding to a zinc ion (Zn). +14 total
0.802 Hit 35.2% 3.65e-06
1979 PA4171 protease PA4171 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019172Catalysis of the reaction: methylglyoxal + H2O = D-lactate. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. +25 total
0.802 Hit 28.2% 9.58e-15
1980 PA4073 aldehyde dehydrogenase PA4073 AlphaFold –
GO:0008957Catalysis of the reaction: 2-phenylacetaldehyde + H2O + NAD+ = 2-phenylacetate + 2 H+ + NADH. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.802 Hit 47.8% 7.94e-61
1981 PA3617 recombinase A PA3617, recA AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140664A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis. +912 total
0.802 Hit 26.5% 1.80e-09
1982 PA3135 transcriptional regulator PA3135 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template. +14 total
0.802 No Hit N/A —
1983 PA2578 acetyltransferase PA2578 Experimental + AlphaFold
2.3.1.-
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.802 No Hit N/A —
1984 PA2505 tyrosine porin OpdT PA2505, opdT AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
0.802 No Hit N/A —
1985 PA2155 cardiolipin synthase 2 clsB, PA2155 AlphaFold
2.7.8.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008808Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. +25 total
0.802 No Hit N/A —
1986 PA1699 hypothetical protein PA1699 AlphaFold –
GO:0050709Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. GO:0030254The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.
0.802 No Hit N/A —
1987 PA1424 hypothetical protein PA1424 AlphaFold
2.5.1.25
GO:0016432Catalysis of the reaction: a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H+. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
0.802 Hit 37.7% 3.61e-07
1988 PA1051 transporter PA1051 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015128Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose. GO:0035429The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose. +14 total
0.802 No Hit N/A —
1989 PA5490 cytochrome C4 cc4, PA5490 Experimental + AlphaFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004129Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out). GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +25 total
0.801 No Hit N/A —
1990 PA5300 cytochrome C5 cycB, PA5300 AlphaFold –
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0005506Binding to an iron (Fe) ion.
0.801 No Hit N/A —
1991 PA4824 hypothetical protein PA4824 AlphaFold – – 0.801 No Hit N/A —
1992 PA4007 gamma-glutamyl phosphate reductase proA, PA4007 AlphaFold
1.2.1.41
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004350Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. +47 total
0.801 Hit 38.8% 2.78e-84
1993 PA3450 antioxidant protein PA3450 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004601Catalysis of the reaction: a reduced substrate + ROOH = an oxidized substrate + ROH + H2O. GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH. +47 total
0.801 Hit 53.2% 8.55e-77
1994 PA3060 pellicle/biofilm biosynthesis protein PelE pelE, PA3060 AlphaFold –
GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
0.801 No Hit N/A —
1995 PA2699 hypothetical protein PA2699 AlphaFold –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
0.801 No Hit N/A —
1996 PA1692 translocation protein in type III secretion PA1692 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0044780The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility. GO:0009306The controlled release of proteins from a cell. +14 total
0.801 No Hit N/A —
1997 PA1629 enoyl-CoA hydratase PA1629 AlphaFold –
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0006635A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.801 Hit 46.3% 4.39e-70
1998 PA3744 ribosome maturation factor RimM rimM, PA3744 Experimental + AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0043022Binding to a ribosome. +25 total
0.8 No Hit N/A —
1999 PA3636 2-dehydro-3-deoxyphosphooctonate aldolase kdsA, PA3636 Experimental + AlphaFold
2.5.1.55
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0009276The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +710 total
0.8 No Hit N/A —
2000 PA3527 dihydroorotase PA3527, pyrC AlphaFold
3.5.2.3
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004151Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H+. +710 total
0.8 No Hit N/A —
Page of 223 · 5572 total proteins