Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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701 proteins Structure: Experimental

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Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 PA0076 hypothetical protein PA0076 Experimental + AlphaFold – – 0.986 No Hit N/A —
2 PA4453 hypothetical protein PA4453 Experimental + AlphaFold – – 0.982 No Hit N/A —
3 PA3885 protein tyrosine phosphatase TpbA PA3885, tpbA Experimental + AlphaFold
3.1.3.16 3.1.3.48
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. GO:0004722Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. +25 total
0.978 No Hit N/A —
4 PA4067 outer membrane protein OprG PA4067, oprG Experimental + AlphaFold –
GO:0044384The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites, occurring in a host cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. +14 total
0.975 No Hit N/A —
5 PA1624 hypothetical protein PA1624 Experimental + AlphaFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.97 No Hit N/A —
6 PA4944 RNA-binding protein Hfq hfq, PA4944 Experimental + AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0009372The cell-cell signaling process in which single-celled organisms carry out coordinated responses by monitoring their own population density, and often also that of other microbes, by producing small, diffusible, signal molecules, detecting the concentration of these molecules, and triggering a signal transduction pathway when a certain threshold is reached. Quorum sensing can occur amongst microbial communities in the environment or within host organisms. +58 total
0.961 No Hit N/A —
7 PA3332 hypothetical protein PA3332 Experimental + AlphaFold – – 0.961 No Hit N/A —
8 PA0125 hypothetical protein PA0125 Experimental + AlphaFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.961 No Hit N/A —
9 PA0124 hypothetical protein PA0124 Experimental + AlphaFold – – 0.961 No Hit N/A —
10 PA5332 catabolite repression control protein exoA, crc, PA5332 Experimental + AlphaFold –
GO:0003906Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). GO:0008311Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule. GO:0046872Binding to a metal ion. +811 total
0.959 Hit 32.7% 8.15e-11
11 PA3006 transcriptional regulator PsrA PA3006, psrA Experimental + AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. +47 total
0.959 No Hit N/A —
12 PA4307 chemotactic transducer PctC pctC, PA4307 Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016597Binding to an amino acid, organic acids containing one or more amino substituents. GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). +36 total
0.958 No Hit N/A —
13 PA4535 hypothetical protein PA4535 Experimental + AlphaFold – – 0.957 No Hit N/A —
14 PA3435 flavodoxin PA3435 Experimental + AlphaFold –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016655Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.
0.957 Hit 37.6% 5.43e-09
15 PA0411 twitching motility protein PilJ pilJ, PA0411 Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004888Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). +25 total
0.957 No Hit N/A —
16 PA1377 hypothetical protein PA1377 Experimental + AlphaFold –
GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.954 No Hit N/A —
17 PA3339 patatin-like protein plpD, PA3339 Experimental + AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0016298Catalysis of the hydrolysis of a lipid. +47 total
0.953 Hit 31.9% 2.62e-26
18 PA3702 two-component response regulator PA3702, wspR Experimental + AlphaFold
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0042802Binding to an identical protein or proteins. +58 total
0.952 No Hit N/A —
19 PA2385 acyl-homoserine lactone acylase PvdQ pvdQ, PA2385, qsc112 Experimental + AlphaFold
3.5.1.97
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. +811 total
0.951 No Hit N/A —
20 PA0012 hypothetical protein PA0012 Experimental + AlphaFold –
GO:0035438Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
0.951 No Hit N/A —
21 PA2852 hypothetical protein PA2852, earP Experimental + AlphaFold
2.4.1.-
GO:0106361Catalysis of the reaction: dTDP-beta-L-rhamnose + L-arginyl-[protein] = dTDP + H+ + N(omega)-(L-rhamnosyl)-L-arginyl-[protein].
0.949 No Hit N/A —
22 PA0867 lysozyme inhibitor PA0867, mliC Experimental + AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
0.949 No Hit N/A —
23 PA1202 hydrolase PA1202 Experimental + AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.947 Hit 28.3% 1.46e-07
24 PA5365 phosphate uptake regulatory protein PhoU PA5365, phoU Experimental + AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0042803Binding to an identical protein to form a homodimer. GO:0060326The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). +69 total
0.943 No Hit N/A —
25 PA0524 nitric oxide reductase subunit B norB, PA0524 Experimental + AlphaFold
1.7.2.5
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004129Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out). GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +69 total
0.943 No Hit N/A —
Page of 29 · 701 total proteins