Proteins

Genome: NZ_AP023069.1

Description: Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome

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44 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
26 HT085_RS00250 hypothetical protein AlphaFold – – No pocket No Hit — —
27 HT085_RS00080 preprotein translocase subunit SecG secG AlphaFold –
GO:0009306The controlled release of proteins from a cell. GO:0015450Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No pocket No Hit — —
28 HT085_RS00100 rhodanese-like domain-containing protein moeZ AlphaFold – – No pocket Hit — —
29 HT085_RS00165 class II fructose-bisphosphate aldolase fda, fba Experimental + AlphaFold
4.1.2.13
GO:0004332Catalysis of the reaction: beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate. GO:0008270Binding to a zinc ion (Zn). GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
No pocket No Hit — —
30 HT085_RS00035 DpnI domain-containing protein dpnC AlphaFold – – No pocket No Hit — —
31 HT085_RS00330 acyltransferase family protein oatA_1, oatA_2 AlphaFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016788Catalysis of the hydrolysis of any ester bond. +14 total
No pocket No Hit — —
32 HT085_RS00235 hypothetical protein AlphaFold – – No pocket No Hit — —
33 HT085_RS00185 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB miaB AlphaFold
2.8.4.3
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0046872Binding to a metal ion. +14 total
No pocket Hit — —
34 HT085_RS00280 iron-sulfur cluster carrier protein ApbC apbC AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140663Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis. GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. +36 total
No pocket Hit — —
35 HT085_RS00255 ComF family protein AlphaFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
No pocket No Hit — —
36 HT085_RS00225 acetyl-CoA carboxylase biotin carboxylase subunit accC AlphaFold
6.3.4.14
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. GO:0004075Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. +14 total
No pocket Hit — —
37 HT085_RS00305 N-acetylmuramate alpha-1-phosphate uridylyltransferase MurU rmlA2, murU AlphaFold –
GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
No pocket Hit — —
38 HT085_RS00315 formate--tetrahydrofolate ligase fhs AlphaFold
6.3.4.3
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004329Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. GO:0035999The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesize other tetrahydrofolate molecules.
No pocket Hit — —
39 HT085_RS00125 prolyl oligopeptidase family serine peptidase AlphaFold –
GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No pocket Hit — —
40 HT085_RS00095 protein-L-isoaspartate O-methyltransferase family protein pcm AlphaFold –
GO:0004719Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No pocket Hit — —
41 HT085_RS00260 endonuclease domain-containing protein Experimental + AlphaFold – – No pocket No Hit — —
42 HT085_RS00290 protein disulfide oxidoreductase resA_1, resA_3 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016209Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
No pocket No Hit — —
43 HT085_RS00010 DNA polymerase III subunit beta dnaN AlphaFold –
GO:0009360The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. +36 total
No pocket No Hit — —
44 HT085_RS00300 4-hydroxyphenylacetate 3-monooxygenase, reductase component hpaC AlphaFold –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016651Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +36 total
No pocket No Hit — —
Page of 2 · 44 total proteins