Proteins

Genome: NZ_AP023069.1

Description: Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome

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62 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 HT085_RS11595 hypothetical protein ColabFold – – No pocket No Hit — —
2 HT085_RS00385 HAD-IA family hydrolase AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008967Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
No pocket No Hit — —
3 HT085_RS00375 4-hydroxy-3-methylbut-2-enyl diphosphate reductase ispH ColabFold –
GO:0019288The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate. GO:0046872Binding to a metal ion.
No pocket No Hit — —
4 HT085_RS00370 signal peptidase II lspA AlphaFold
3.4.23.36
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0004190Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No pocket No Hit — —
5 HT085_RS00365 opacity family porin ColabFold – – No pocket No Hit — —
6 HT085_RS00360 hypothetical protein ColabFold – – No pocket No Hit — —
7 HT085_RS00355 isoleucine--tRNA ligase ileS ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA.
No pocket Hit — —
8 HT085_RS00350 bifunctional riboflavin kinase/FAD synthetase ribF ColabFold – – No pocket Hit — —
9 HT085_RS00345 opacity family porin ColabFold – – No pocket No Hit — —
10 HT085_RS00340 hypothetical protein ColabFold – – No pocket No Hit — —
11 HT085_RS00335 tyrosine--tRNA ligase tyrS AlphaFold
6.1.1.1
GO:0004831Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+. GO:0006437The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0003723Binding to an RNA molecule or a portion thereof. +36 total
No pocket Hit — —
12 HT085_RS00330 acyltransferase family protein oatA_1, oatA_2 AlphaFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016788Catalysis of the hydrolysis of any ester bond. +14 total
No pocket No Hit — —
13 HT085_RS00325 hypothetical protein AlphaFold – – No pocket No Hit — —
14 HT085_RS00320 redox-regulated ATPase YchF engD, ychF AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005525Binding to GTP, guanosine triphosphate. +36 total
No pocket Hit — —
15 HT085_RS00315 formate--tetrahydrofolate ligase fhs AlphaFold
6.3.4.3
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004329Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. GO:0035999The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesize other tetrahydrofolate molecules.
No pocket Hit — —
16 HT085_RS00305 N-acetylmuramate alpha-1-phosphate uridylyltransferase MurU rmlA2, murU AlphaFold –
GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
No pocket Hit — —
17 HT085_RS00300 4-hydroxyphenylacetate 3-monooxygenase, reductase component hpaC AlphaFold –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016651Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +36 total
No pocket No Hit — —
18 HT085_RS00295 MarR family adhesin repressor NadR hpcR, ohrR, nadR, farR, marR1 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No pocket No Hit — —
19 HT085_RS00290 protein disulfide oxidoreductase resA_1, resA_3 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016209Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
No pocket No Hit — —
20 HT085_RS00280 iron-sulfur cluster carrier protein ApbC apbC AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140663Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis. GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. +36 total
No pocket Hit — —
21 HT085_RS00275 PilC family type IV pilus tip adhesin pilC ColabFold – – No pocket No Hit — —
22 HT085_RS00270 glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit carA ColabFold –
GO:0006207The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
No pocket Hit — —
23 HT085_RS00260 endonuclease domain-containing protein Experimental + AlphaFold – – No pocket No Hit — —
24 HT085_RS00255 ComF family protein AlphaFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
No pocket No Hit — —
25 HT085_RS00250 hypothetical protein AlphaFold – – No pocket No Hit — —
Page of 3 · 62 total proteins