Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4601 KP13_04902 TonB-dependent siderophore receptor AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015891The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015343Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). +36 total
0.997 No Hit 0.0% —
4602 KP13_04903 hypothetical protein AlphaFold + ColabFold –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
0.261 No Hit 0.0% —
4603 KP13_04904 NADH dehydrogenase ndh AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003955Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol. GO:0019646A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient.
0.818 No Hit 0.0% —
4604 KP13_04905 hypothetical protein AlphaFold + ColabFold – – 0.527 No Hit 0.0% —
4605 KP13_04907 Thiamine kinase thiK AlphaFold + ColabFold
2.7.1.89
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0019165Catalysis of the reaction: ATP + thiamine = ADP + 2 H+ + thiamine phosphate. GO:0006772The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. +25 total
0.505 No Hit 0.0% —
4606 KP13_04908 fibronectin-binding protein AlphaFold + ColabFold –
GO:0031241The leaflet of a outer cell membrane that faces the periplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0030234A molecular function regulator that modulates a catalytic activity. GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. +14 total
0.579 No Hit 0.0% —
4607 KP13_04909 hypothetical protein AlphaFold + ColabFold – – 0.421 No Hit 0.0% —
4608 KP13_04911 PTS system glucose-specific EIICB component ptsG AlphaFold + ColabFold
2.7.1.199
GO:1904659The process in which D-glucose is transported across a membrane. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005355OBSOLETE. Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. +69 total
0.928 No Hit 0.0% —
4609 KP13_04913 DNA polymerase III subunit delta' holB AlphaFold + ColabFold
2.7.7.7
GO:0009360The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. +36 total
0.423 No Hit 0.0% —
4610 KP13_04915 hypothetical protein AlphaFold + ColabFold
4.2.2.29
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0008932Catalysis of the endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. +25 total
0.631 No Hit 0.0% —
4611 KP13_04916 Aminodeoxychorismate lyase pabC AlphaFold + ColabFold
4.1.3.38
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0046656The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +36 total
0.407 No Hit 0.0% —
4612 KP13_04921 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH AlphaFold + ColabFold
2.3.1.180
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. +25 total
0.217 No Hit 0.0% —
4613 KP13_04922 Phosphate acyltransferase plsX AlphaFold + ColabFold –
GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.905 No Hit 0.0% —
4614 KP13_04923 hypothetical protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0042254A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
0.364 No Hit 0.0% —
4615 KP13_04926 Ribonuclease E rne AlphaFold + ColabFold
3.1.26.12
GO:0003676Binding to a nucleic acid. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0003723Binding to an RNA molecule or a portion thereof. +1114 total
0.832 No Hit 0.0% —
4616 KP13_04928 major facilitator family protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.929 No Hit 0.0% —
4617 KP13_04929 Virulence factor mviN mviN AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015648Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +36 total
0.789 No Hit 0.0% —
4618 KP13_04930 Virulence factor mviM mviM AlphaFold + ColabFold –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.311 No Hit 0.0% —
4619 KP13_04931 hypothetical protein AlphaFold + ColabFold – – 0.338 No Hit 0.0% —
4620 KP13_04932 Ribosomal-protein-alanine acetyltransferase rimJ AlphaFold + ColabFold
2.3.1.267
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008999Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H+ + N-terminal N(alpha)-acetyl-L-alanyl-[protein].
0.552 No Hit 0.0% —
4621 KP13_04933 Multidrug resistance protein mdtH mdtH AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.801 No Hit 0.0% —
4622 KP13_04934 hypothetical protein AlphaFold + ColabFold – – 0.585 No Hit 0.0% —
4623 KP13_04936 hypothetical protein ColabFold – – 0.141 No Hit 0.0% —
4624 KP13_04937 DNA-damage-inducible protein I AlphaFold + ColabFold –
GO:0009432An error-prone process for repairing damaged microbial DNA.
0.36 No Hit 0.0% —
4625 KP13_04938 hypothetical protein AlphaFold + ColabFold – – 0.511 No Hit 0.0% —
Page of 234 · 5842 total proteins