Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4626 KP13_04939 Biofilm regulator bssS bssS AlphaFold + ColabFold – – 0.76 No Hit 0.0% —
4627 KP13_04942 Lipid A biosynthesis lauroyl acyltransferase AlphaFold + ColabFold
2.3.1.241
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. +47 total
0.736 No Hit 0.0% —
4628 KP13_04944 hypothetical protein AlphaFold + ColabFold – – 0.195 No Hit 0.0% —
4629 KP13_04945 hypothetical protein AlphaFold + ColabFold – – 0.722 No Hit 0.0% —
4630 KP13_04946 Glucans biosynthesis glucosyltransferase H mdoH AlphaFold + ColabFold
2.4.1.-
GO:0016758Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009250The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.
0.982 No Hit 0.0% —
4631 KP13_04947 Glucans biosynthesis protein G mdoG AlphaFold + ColabFold –
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +47 total
0.43 No Hit 0.0% —
4632 KP13_04948 hypothetical protein AlphaFold + ColabFold – – 0.214 No Hit 0.0% —
4633 KP13_04949 Glucans biosynthesis protein C mdoC AlphaFold + ColabFold
2.1.-.-
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0016741Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.878 No Hit 0.0% —
4634 KP13_04950 HTH-type transcriptional regulator betI AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
0.186 No Hit 0.0% —
4635 KP13_04952 Inner membrane protein AlphaFold + ColabFold – – 0.876 No Hit 0.0% —
4636 KP13_04953 chaperone TorD family protein AlphaFold + ColabFold – – 0.557 No Hit 0.0% —
4637 KP13_04954 hypothetical protein AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.344 No Hit 0.0% —
4638 KP13_04958 hypothetical protein AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.845 No Hit 0.0% —
4639 KP13_04959 hypothetical protein AlphaFold + ColabFold – – 0.886 No Hit 0.0% —
4640 KP13_04960 hypothetical protein AlphaFold + ColabFold – – 0.547 No Hit 0.0% —
4641 KP13_04961 hypothetical protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.745 No Hit 0.0% —
4642 KP13_04963 Protein samA samA AlphaFold + ColabFold
2.7.7.7 3.4.21.-
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. +36 total
0.582 No Hit 0.0% —
4643 KP13_04964 reverse transcriptase domain-containing protein AlphaFold + ColabFold –
GO:0003964Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time.
0.517 No Hit 0.0% —
4644 KP13_04967 Phenylacetic acid degradation protein paaA paaA AlphaFold + ColabFold –
GO:0097266Catalysis of the reaction: phenylacetyl-CoA + H+ + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP+. GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.534 No Hit 0.0% —
4645 KP13_04968 Phenylacetic acid degradation protein paaB paaB Experimental + AlphaFold + ColabFold – – 0.242 No Hit 0.0% —
4646 KP13_04969 Phenylacetic acid degradation protein paaC paaC Experimental + AlphaFold + ColabFold –
GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate.
0.364 No Hit 0.0% —
4647 KP13_04970 Phenylacetic acid degradation protein paaD paaD AlphaFold + ColabFold – – 0.361 No Hit 0.0% —
4648 KP13_04975 Acyl-coenzyme A thioesterase paaI paaI AlphaFold + ColabFold –
GO:0016790Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. GO:0016289Catalysis of the reaction: an acyl-CoA + H2O = a carboxylate + CoA + H+.
0.509 No Hit 0.0% —
4649 KP13_04977 Phenylacetate-coenzyme A ligase paaK AlphaFold + ColabFold
6.2.1.30
GO:0047475Catalysis of the reaction: ATP + CoA + phenylacetate = AMP + diphosphate + H+ + phenylacetyl-CoA. GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.155 No Hit 0.0% —
4650 KP13_04978 Phenylacetic acid degradation operon negative regulatory protein paaX paaX AlphaFold + ColabFold –
GO:0006351The synthesis of an RNA transcript from a DNA template.
0.501 No Hit 0.0% —
Page of 234 · 5842 total proteins