Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

Scoring formula None

Sorted by Human off-target (descending)

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
126 KP13_32100 F-type conjugal transfer TraG-like protein AlphaFold DB model + ColabFold model – – No map 0.703 No Hit 0.0% —
127 KP13_32099 F-type conjugal transfer TraF-like protein AlphaFold DB model + ColabFold model – – No map 0.284 No Hit 0.0% —
128 KP13_32098 Lambda repressor-like, DNA-binding domain-containing protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.368 No Hit 0.0% —
129 KP13_32097 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.54 No Hit 0.0% —
130 KP13_32096 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.185 No Hit 0.0% —
131 KP13_32095 peptidase family S49 AlphaFold DB model + ColabFold model –
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
No map 0.451 No Hit 0.0% —
132 KP13_32094 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.906 No Hit 0.0% —
133 KP13_32093 Insertion sequence IS408 putative ATP-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.877 No Hit 0.0% —
134 KP13_32092 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.529 No Hit 0.0% —
135 KP13_32090 hypothetical protein ColabFold model – – No map 0.568 No Hit 0.0% —
136 KP13_32089 modification methylase HhaI hhaIM AlphaFold DB model + ColabFold model
2.1.1.37
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0003886Catalysis of the reaction: a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H+ + S-adenosyl-L-homocysteine. GO:0009307A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme. +14 total
No map 0.298 No Hit 0.0% —
137 KP13_32087 conjugal transfer TraD-like protein AlphaFold DB model + ColabFold model – – No map 0.623 No Hit 0.0% —
138 KP13_32086 conjugal transfer traI-like protein AlphaFold DB model + ColabFold model – – No map 0.563 No Hit 0.0% —
139 KP13_32085 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.094 No Hit 0.0% —
140 KP13_32084 transposase for transposon gamma-delta-like protein ColabFold model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
No map 0.76 No Hit 0.0% —
141 KP13_32083 putative exonuclease AlphaFold DB model + ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0006259Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
No map 0.331 No Hit 0.0% —
142 KP13_32082 hypothetical protein ColabFold model – – No map 0.356 No Hit 0.0% —
143 KP13_32080 hypothetical protein ColabFold model – – No map 0.965 No Hit 0.0% —
144 KP13_32079 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.662 No Hit 0.0% —
145 KP13_32076 transposase insD for insertion element IS2 ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.373 No Hit 0.0% —
146 KP13_32075 transposon Tn3 resolvase ColabFold model –
GO:0000150Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.19 No Hit 0.0% —
147 KP13_32073 hypothetical protein ColabFold model – – No map 0.184 No Hit 0.0% —
148 KP13_32072 resolvase resD AlphaFold DB model + ColabFold model –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.982 No Hit 0.0% —
149 KP13_32071 resolvase AlphaFold DB model + ColabFold model –
GO:0000150Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
No map 0.835 No Hit 0.0% —
150 KP13_32070 putative transposase AlphaFold DB model + ColabFold model – – No map 0.689 No Hit 0.0% —
Page of 234 · 5842 total proteins