Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2751 PA3361 fucose-binding lectin PA-IIL PA3361, lecB Experimental + AlphaFold –
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0046872Binding to a metal ion. GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
No map 0.737 No Hit N/A —
2752 PA3242 lipid A biosynthesis lauroyl acyltransferase lpxL, PA3242 AlphaFold
2.3.1.241
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). +58 total
No map 0.737 No Hit N/A —
2753 PA2608 hypothetical protein PA2608 AlphaFold
2.8.1.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0097163Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. +14 total
No map 0.737 No Hit N/A —
2754 PA2535 oxidoreductase PA2535 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.737 Hit 32.6% 9.99e-06
2755 PA2522 outer membrane protein CzcC czcC, PA2522 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +14 total
No map 0.737 No Hit N/A —
2756 PA2449 transcriptional regulator PA2449 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +1215 total
No map 0.737 No Hit N/A —
2757 PA1561 aerotaxis receptor Aer tlpC, aer, PA1561 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004888Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0009454The directed movement of a motile cell or organism in response to environmental oxygen. +58 total
No map 0.737 No Hit N/A —
2758 PA0686 type II secretion system protein HxcR PA0686, hxcR AlphaFold
7.4.2.8
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. +47 total
No map 0.737 No Hit N/A —
2759 PA0447 glutaryl-CoA dehydrogenase PA0447, gcdH AlphaFold
1.3.8.6
GO:0000062Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0004361Catalysis of the reaction: glutaryl-CoA + 2 H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]. +47 total
No map 0.737 Hit 65.4% 0.00e+00
2760 PA0269 hypothetical protein PA0269 Experimental + AlphaFold –
GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
No map 0.737 No Hit N/A —
2761 PA0100 hypothetical protein tsi7, PA0100 AlphaFold – – No map 0.737 No Hit N/A —
2762 PA4973 thiamine biosynthesis protein ThiC PA4973, thiC AlphaFold
4.1.99.17
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0070284Catalysis of the reaction: 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + CO + 5'-deoxyadenosine + formate + L-methionine + 3 H+. +58 total
No map 0.736 No Hit N/A —
2763 PA4949 hypothetical protein nnrD, nnrE, PA4949 AlphaFold –
GO:0052855Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + H+ + NAD(P)H + phosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. +47 total
No map 0.736 Hit 32.8% 6.10e-16
2764 PA4869 hypothetical protein PA4869 AlphaFold – – No map 0.736 No Hit N/A —
2765 PA4653 hypothetical protein PA4653 AlphaFold – – No map 0.736 No Hit N/A —
2766 PA4567 50S ribosomal protein L27 rpmA, PA4567 AlphaFold –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0043022Binding to a ribosome. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +36 total
No map 0.736 Hit 43.5% 5.74e-11
2767 PA4145 transcriptional regulator PA4145 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.736 No Hit N/A —
2768 PA4054 3,4-dihydroxy-2-butanone-4-phosphate synthase ribB, PA4054 AlphaFold
4.1.99.12
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008686Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H+. GO:0003935Catalysis of the reaction: GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H+ + 2 phosphate. +36 total
No map 0.736 No Hit N/A —
2769 PA3762 hypothetical protein PA3762 AlphaFold – – No map 0.736 No Hit N/A —
2770 PA2982 hypothetical protein PA2982 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.736 No Hit N/A —
2771 PA2892 short-chain dehydrogenase atuG, PA2892 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0046247The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units.
No map 0.736 Hit 54.0% 2.00e-97
2772 PA2470 gentisate 1,2-dioxygenase gtdA, PA2470 AlphaFold
1.13.11.4
GO:0047922Catalysis of the reaction: 2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H+. GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate.
No map 0.736 No Hit N/A —
2773 PA1940 hypothetical protein PA1940 AlphaFold
1.11.1.6
GO:0004096Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0006979Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
No map 0.736 Hit 24.0% 1.39e-06
2774 PA1402 hypothetical protein PA1402 AlphaFold –
GO:0008171Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
No map 0.736 No Hit N/A —
2775 PA1398 hypothetical protein PA1398 AlphaFold – – No map 0.736 No Hit N/A —
Page of 223 · 5572 total proteins