Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3201 PA0519 nitrite reductase PA0519, nirS Experimental + AlphaFold
1.7.2.1 1.7.99.1
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +36 total
No map 0.699 No Hit N/A —
3202 PA0336 RNA pyrophosphohydrolase ygdP ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.699 No Hit N/A —
3203 PA5496 hypothetical protein PA5496, nrdJb AlphaFold
1.17.4.1
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0004748Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. GO:0071897The biosynthetic process resulting in the formation of DNA.
No map 0.698 No Hit N/A —
3204 PA5145 hypothetical protein PA5145 AlphaFold –
GO:0047545Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.698 Hit 41.7% 9.54e-20
3205 PA5109 hypothetical protein PA5109 AlphaFold –
GO:0005515Binding to a protein.
No map 0.698 No Hit N/A —
3206 PA4015 hypothetical protein PA4015 AlphaFold –
GO:0018812Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
No map 0.698 No Hit N/A —
3207 PA3552 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase arnB, PA3552 AlphaFold
2.6.1.87
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +69 total
No map 0.698 No Hit N/A —
3208 PA1385 glycosyl transferase family protein PA1385 AlphaFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:1901135The chemical reactions and pathways involving carbohydrate derivative.
No map 0.698 No Hit N/A —
3209 PA0964 transcriptional regulator PmpR PA0964, pmpR AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0071281Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. +14 total
No map 0.698 Hit 27.9% 4.29e-26
3210 PA0429 hypothetical protein PA0429 AlphaFold – – No map 0.698 No Hit N/A —
3211 PA0400 cystathionine gamma-lyase PA0400 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004123Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+. GO:0003962Catalysis of the reaction: L-cysteine + O-succinyl-L-homoserine = H+ + L,L-cystathionine + succinate. +47 total
No map 0.698 Hit 52.2% 1.19e-128
3212 PA0234 hypothetical protein PA0234 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
No map 0.698 No Hit N/A —
3213 PA5420 formyltetrahydrofolate deformylase PA5420, purU2, purU AlphaFold
3.5.1.10
GO:0008864Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H+. GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. GO:0006730The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. +14 total
No map 0.697 Hit 33.3% 1.50e-15
3214 PA3589 acetyl-CoA acetyltransferase PA3589 Experimental + AlphaFold
2.3.1.16
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0033812Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA. GO:0003988Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. +47 total
No map 0.697 Hit 46.9% 1.63e-52
3215 PA3348 chemotaxis protein methyltransferase PA3348, cheR1 Experimental + AlphaFold
2.1.1.80
GO:0008276Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0008983Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester. GO:0032259The process in which a methyl group is covalently attached to a molecule. +14 total
No map 0.697 No Hit N/A —
3216 PA2602 hypothetical protein PA2602 Experimental + AlphaFold
1.13.11.91
GO:0008198Binding to a ferrous iron ion, Fe(II). GO:0005506Binding to an iron (Fe) ion. GO:0016702Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
No map 0.697 No Hit N/A —
3217 PA1702 hypothetical protein PA1702 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0030254The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins. GO:0005515Binding to a protein.
No map 0.697 No Hit N/A —
3218 PA1663 transcriptional regulator PA1663 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +912 total
No map 0.697 No Hit N/A —
3219 PA1618 esterase PA1618 Experimental + AlphaFold
3.1.2.-
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0061522Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H+.
No map 0.697 No Hit N/A —
3220 PA1142 transcriptional regulator PA1142 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.697 No Hit N/A —
3221 PA1086 flagellar hook-associated protein FlgK PA1086, flgK AlphaFold –
GO:0009424The portion of the bacterial-type flagellum that connects the filament to the basal body. GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0005198The action of a molecule that contributes to the structural integrity of a complex. +14 total
No map 0.697 No Hit N/A —
3222 PA0597 nucleotidyl transferase murU, PA0597 Experimental + AlphaFold
2.7.7.99
GO:0046872Binding to a metal ion. GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +58 total
No map 0.697 Hit 41.7% 1.12e-21
3223 PA5403 transcriptional regulator PA5403 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.696 No Hit N/A —
3224 PA5092 imidazolonepropionase hutI, PA5092 AlphaFold
3.5.2.7
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0050480Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H2O = N-formimidoyl-L-glutamate + H+. GO:0005506Binding to an iron (Fe) ion. +710 total
No map 0.696 Hit 37.4% 1.44e-68
3225 PA4724 glutamyl-Q tRNA(Asp) synthetase gluQ, PA4724 AlphaFold
6.1.1.-
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004818Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). +69 total
No map 0.696 Hit 35.9% 2.37e-38
Page of 223 · 5572 total proteins