Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3226 PA3667 cysteine desulfurase csd, PA3667 AlphaFold DB model
2.8.1.7
GO:0031071Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006534OBSOLETE. The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. +14 total
No map 0.696 Hit 37.3% 6.32e-06
3227 PA1528 cell division protein ZipA PA1528, zipA AlphaFold DB model –
GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0000917The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. +36 total
No map 0.696 No Hit N/A —
3228 PA1523 xanthine dehydrogenase PA1523, xdhB AlphaFold DB model –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0005506Binding to an iron (Fe) ion. GO:0030151Binding to a molybdenum ion (Mo). +14 total
No map 0.696 Hit 49.7% 1.22e-43
3229 PA1483a hypothetical protein ColabFold model – – No map 0.696 Hit 48.2% 5.57e-06
3230 PA5343 hypothetical protein PA5343 AlphaFold DB model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004029Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH.
No map 0.695 No Hit N/A —
3231 PA4843 two-component response regulator PA4843 AlphaFold DB model
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species. +58 total
No map 0.695 No Hit N/A —
3232 PA4772 ferredoxin PA4772 AlphaFold DB model
1.1.2.4
GO:0004458Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate. GO:0008720Catalysis of the reaction: (R)-lactate + NAD+ = H+ + NADH + pyruvate. GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +58 total
No map 0.695 Hit 27.9% 6.71e-17
3233 PA4510 hypothetical protein PA4510 AlphaFold DB model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.695 No Hit N/A —
3234 PA3688 hypothetical protein PA3688 AlphaFold DB model – – No map 0.695 No Hit N/A —
3235 PA3668 hypothetical protein PA3668 AlphaFold DB model –
GO:1990228A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor). GO:0008047A molecular function regulator that increases a catalytic activity. GO:0097163Covalently binding to sulfur and delivering it to an acceptor molecule.
No map 0.695 No Hit N/A —
3236 PA3197 hypothetical protein PA3197 AlphaFold DB model –
GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0051304The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II).
No map 0.695 No Hit N/A —
3237 PA2110 hypothetical protein PA2110 AlphaFold DB model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.695 No Hit N/A —
3238 PA1201 transcriptional regulator PA1201 AlphaFold DB model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template. +14 total
No map 0.695 No Hit N/A —
3239 PA0933 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD ygcA ColabFold model –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.
No map 0.695 Hit 38.0% 1.04e-22
3240 PA5514 beta-lactamase PA5514 AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
No map 0.694 No Hit N/A —
3241 PA4986 oxidoreductase PA4986 AlphaFold DB model –
GO:0008670Catalysis of the reactions: a 4,5-saturated-(2E)-enoyl-CoA + NADP+ = a (2E,4E)-dienoyl-CoA + H+ + NADPH, and a (2E,4Z)-dienoyl-CoA + H+ + NADPH = a 4,5-saturated-(2E)-enoyl-CoA + NADP+. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. +36 total
No map 0.694 No Hit N/A —
3242 PA4407 cell division protein FtsZ PA4407, ftsZ Experimental + AlphaFold DB model –
GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005525Binding to GTP, guanosine triphosphate. +58 total
No map 0.694 No Hit N/A —
3243 PA4229 pyochelin biosynthetic protein PchC pchC, PA4229 AlphaFold DB model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0008610The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. GO:0042864The chemical reactions and pathways resulting in the formation of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid). +14 total
No map 0.694 Hit 34.4% 7.41e-15
3244 PA4089 3-ketoacyl-ACP reductase PA4089 AlphaFold DB model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.694 Hit 41.9% 6.59e-10
3245 PA3754 hypothetical protein PA3754 AlphaFold DB model –
GO:0010945Catalysis of the reaction: an acyl-coenzyme A or its derivatives + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H+. This reaction can also use coenzyme A as a substrate. GO:0046872Binding to a metal ion.
No map 0.694 Hit 38.8% 2.91e-12
3246 PA1307 hypothetical protein PA1307 Experimental + AlphaFold DB model – – No map 0.694 No Hit N/A —
3247 PA1270 hypothetical protein PA1270 AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.694 No Hit N/A —
3248 PA1161 rRNA methyltransferase PA1161, rrmA AlphaFold DB model –
GO:0046872Binding to a metal ion. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
No map 0.694 No Hit N/A —
3249 PA1014 glycosyl transferase family protein PA1014 AlphaFold DB model –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0008919Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide.
No map 0.694 No Hit N/A —
3250 PA5464 hypothetical protein PA5464 AlphaFold DB model – – No map 0.693 No Hit N/A —
Page of 223 · 5572 total proteins