Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3276 PA1649 short-chain dehydrogenase PA1649 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.692 Hit 42.4% 1.27e-10
3277 PA0865 4-hydroxyphenylpyruvate dioxygenase hpd, PA0865 AlphaFold
1.13.11.27
GO:0003868Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. GO:0046872Binding to a metal ion. GO:0006559The chemical reactions and pathways resulting in the breakdown of L-phenylalanine. +36 total
No map 0.692 Hit 31.7% 2.58e-34
3278 PA4339 phospholipase PA4339 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008808Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. GO:0032049The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. +14 total
No map 0.691 No Hit N/A —
3279 PA4314 formyltetrahydrofolate deformylase purU1, purU, PA4314 AlphaFold
3.5.1.10
GO:0008864Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H+. GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. GO:0006730The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. +14 total
No map 0.691 Hit 31.3% 1.37e-16
3280 PA4097 alcohol dehydrogenase PA4097 AlphaFold –
GO:0008868Catalysis of the reaction: galactitol-1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+. GO:0008270Binding to a zinc ion (Zn). GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.691 Hit 36.8% 3.39e-08
3281 PA3883 short-chain dehydrogenase PA3883 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.691 Hit 42.7% 7.42e-11
3282 PA2266 cytochrome C PA2266 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +36 total
No map 0.691 No Hit N/A —
3283 PA2226 hypothetical protein PA2226 AlphaFold – – No map 0.691 No Hit N/A —
3284 PA2134 hypothetical protein PA2134 AlphaFold – – No map 0.691 No Hit N/A —
3285 PA2044 hypothetical protein PA2044 AlphaFold – – No map 0.691 No Hit N/A —
3286 PA1989 coenzyme PQQ synthesis protein E PA1989, pqqE AlphaFold
1.21.98.4
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0009975Catalysis of a ring closure reaction. GO:0005506Binding to an iron (Fe) ion. +710 total
No map 0.691 No Hit N/A —
3287 PA1085 peptidoglycan hydrolase FlgJ PA1085, flgJ AlphaFold
3.2.1.-
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004040Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH4+. GO:0016798Catalysis of the hydrolysis of any glycosyl bond. +36 total
No map 0.691 No Hit N/A —
3288 PA0854 fumarate hydratase fumC2 ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. +36 total
No map 0.691 Hit 59.6% 3.13e-48
3289 PA0413 chemotactic signal transduction system protein PA0413, chpA AlphaFold
2.7.13.3
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). +69 total
No map 0.691 No Hit N/A —
3290 PA5456 hypothetical protein PA5456 AlphaFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:0009243The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide.
No map 0.69 No Hit N/A —
3291 PA4893 urease accessory protein UreG PA4893, ureG AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005525Binding to GTP, guanosine triphosphate. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. +710 total
No map 0.69 No Hit N/A —
3292 PA4660 deoxyribodipyrimidine photolyase PA4660, phr AlphaFold
4.1.99.3
GO:0003904Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +36 total
No map 0.69 Hit 30.0% 1.96e-37
3293 PA3595 major facilitator superfamily transporter PA3595 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
No map 0.69 No Hit N/A —
3294 PA3570 methylmalonate-semialdehyde dehydrogenase PA3570, mmsA AlphaFold
1.2.1.27
GO:0004491Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + hydrogencarbonate + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product. GO:0006574The chemical reactions and pathways resulting in the breakdown of L-valine. GO:0006210The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base. +25 total
No map 0.69 Hit 55.5% 3.64e-100
3295 PA2700 OpdB proline porin PA2700, opdB AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
No map 0.69 No Hit N/A —
3296 PA1778 uroporphyrin-III C-methyltransferase cobA, PA1778 AlphaFold
2.1.1.107
GO:0004851Catalysis of the reaction: uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H+. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0032259The process in which a methyl group is covalently attached to a molecule. +25 total
No map 0.69 No Hit N/A —
3297 PA1623 hypothetical protein PA1623 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004364Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+.
No map 0.69 Hit 36.0% 4.45e-08
3298 PA0650 anthranilate phosphoribosyltransferase trpD, PA0650 AlphaFold
2.4.2.18
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004048Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate. GO:0000287Binding to a magnesium (Mg) ion. +25 total
No map 0.69 No Hit N/A —
3299 PA0556 hypothetical protein PA0556 AlphaFold – – No map 0.69 No Hit N/A —
3300 PA0419 16S ribosomal RNA methyltransferase RsmE PA0419 AlphaFold
2.1.1.193
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0070042Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine. GO:0070475The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. +25 total
No map 0.69 No Hit N/A —
Page of 223 · 5572 total proteins