Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5251 PA4873 heat-shock protein PA4873 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140662Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
0.252 Hit 26.8% 8.02e-08
5252 PA3338 hypothetical protein PA3338 Experimental + AlphaFold – – 0.252 No Hit N/A —
5253 PA1362 hypothetical protein PA1362 AlphaFold – – 0.252 No Hit N/A —
5254 PA2195 hydrogen cyanide synthase subunit HcnC hcnC, PA2195 AlphaFold
1.4.99.5
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0050622Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2. +14 total
0.251 Hit 25.2% 6.23e-06
5255 PA5055 hypothetical protein PA5055 AlphaFold –
GO:0046872Binding to a metal ion.
0.249 No Hit N/A —
5256 PA1639 hypothetical protein PA1639 AlphaFold – – 0.249 No Hit N/A —
5257 PA2912 ABC transporter ATP-binding protein PA2912 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.247 Hit 34.0% 1.22e-06
5258 PA3485 hypothetical protein tsi3, PA3485 Experimental + AlphaFold –
GO:0046872Binding to a metal ion.
0.246 No Hit N/A —
5259 PA4232 single-stranded DNA-binding protein ssb, PA4232 Experimental + AlphaFold –
GO:0009295The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. GO:0008047A molecular function regulator that increases a catalytic activity. GO:0003697Binding to single-stranded DNA. +36 total
0.245 Hit 39.3% 2.70e-14
5260 PA2635 hypothetical protein PA2635 AlphaFold – – 0.245 No Hit N/A —
5261 PA2591 transcriptional regulator PA2591 Experimental + AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0001217A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. +47 total
0.245 No Hit N/A —
5262 PA4241 30S ribosomal protein S13 rpsM, PA4241 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0015935The smaller of the two subunits of a ribosome. GO:0019843Binding to a ribosomal RNA. +69 total
0.244 No Hit N/A —
5263 PA1611 sensor/response regulator hybrid protein PA1611 Experimental + AlphaFold
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009927Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator. +710 total
0.244 No Hit N/A —
5264 PA3805 type 4 fimbrial biogenesis protein PilF PA3805, pilF Experimental + AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0030911Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices. GO:0009297The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. +47 total
0.242 Hit 28.8% 2.00e-06
5265 PA4390 hypothetical protein PA4390 AlphaFold – – 0.241 No Hit N/A —
5266 PA4298 hypothetical protein PA4298 AlphaFold – – 0.239 No Hit N/A —
5267 PA2750a hypothetical protein ColabFold – – 0.239 No Hit N/A —
5268 PA1444 flagellar motor switch protein FliN fliN, PA1444 AlphaFold –
GO:0009425One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003774Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). +69 total
0.239 No Hit N/A —
5269 PA4303 hypothetical protein tadZ, PA4303 Experimental + AlphaFold –
GO:0009898The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
0.238 No Hit N/A —
5270 PA0330 ribose-5-phosphate isomerase A rpiA, PA0330 Experimental + AlphaFold
5.3.1.6
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004751Catalysis of the reaction: aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate. GO:0006014The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. +14 total
0.238 Hit 36.6% 1.50e-26
5271 PA5117 regulatory protein TypA bipA, PA5117, typA AlphaFold
3.6.5.-
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:1990904A macromolecular complex that contains both RNA and protein molecules. GO:0005525Binding to GTP, guanosine triphosphate. +1316 total
0.237 Hit 56.2% 9.52e-11
5272 PA5187 acyl-CoA dehydrogenase PA5187 AlphaFold
1.3.99.41
GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
0.236 Hit 43.1% 8.18e-06
5273 PA4277 elongation factor Tu tufB, PA4277, tufA AlphaFold
3.6.5.3
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005525Binding to GTP, guanosine triphosphate. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. +36 total
0.236 Hit 81.8% 1.19e-10
5274 PA1831 hypothetical protein PA1831 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.
0.234 No Hit N/A —
5275 PA1890 glutathione S-transferase PA1890 AlphaFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.233 Hit 34.8% 3.53e-07
Page of 223 · 5572 total proteins