Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5301 PA1493 sulfate ABC transporter substrate-binding protein PA1493, cysP AlphaFold –
GO:0005615OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0140104Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location. +36 total
0.204 No Hit N/A —
5302 PA3818 type III secretion system regulator SuhB PA3818, suhB Experimental + AlphaFold
3.1.3.25
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008934Catalysis of the reaction: 1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. GO:0046872Binding to a metal ion. +69 total
0.203 Hit 47.1% 2.43e-14
5303 PA0697 hypothetical protein PA0697 AlphaFold – – 0.202 No Hit N/A —
5304 PA4543 hypothetical protein PA4543 AlphaFold
2.4.2.1 3.5.4.4 2.4.2.28
GO:0004000Catalysis of the reaction: adenosine + H2O = inosine + NH4+. GO:0005507Binding to a copper (Cu) ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
0.201 Hit 36.1% 3.34e-10
5305 PA2072 hypothetical protein PA2072 Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.201 No Hit N/A —
5306 PA1456 chemotaxis protein CheY PA1456, cheY AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872Binding to a metal ion. GO:0097588Cell motility due to movement of bacterial- or archaeal-type flagella. +36 total
No pocket No Hit N/A —
5307 PA0380 sulfur carrier protein ThiS PA0380 AlphaFold –
GO:1902503A protein complex which is capable of adenylyltransferase activity. GO:0097163Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0052837The chemical reactions and pathways resulting in the formation of a thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position.
No pocket No Hit N/A —
5308 PA3576 hypothetical protein PA3576 AlphaFold – – No pocket No Hit N/A —
5309 PA1503 hypothetical protein PA1503 AlphaFold – – No pocket No Hit N/A —
5310 PA1852 hypothetical protein PA1852 AlphaFold – – No pocket No Hit N/A —
5311 PA4377 hypothetical protein PA4377 AlphaFold – – No pocket No Hit N/A —
5312 PA3021 hypothetical protein PA3021 AlphaFold – – No pocket No Hit N/A —
5313 PA2905 precorrin-8X methylmutase PA2905, cobH AlphaFold
5.4.99.61
GO:0016993Catalysis of the reaction: precorrin-8X = hydrogenobyrinate. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
No pocket No Hit N/A —
5314 PA0351 hypothetical protein PA0351 AlphaFold
3.1.4.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
No pocket No Hit N/A —
5315 PA3988 hypothetical protein lptE, PA3988 Experimental + AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:1990351A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. GO:0001530Binding to a lipopolysaccharide. +36 total
No pocket No Hit N/A —
5316 PA1518 5-hydroxyisourate hydrolase PA1518 AlphaFold
3.5.2.17
GO:0033971Catalysis of the reaction: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+. GO:0006144The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
No pocket No Hit N/A —
5317 PA1963 hypothetical protein PA1963 AlphaFold – – No pocket No Hit N/A —
5318 PA2173a hypothetical protein ColabFold – – No pocket No Hit N/A —
5319 PA4953 flagellar motor protein MotB PA4953, motB AlphaFold –
GO:0120101A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. GO:0071973Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0071978Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.
No pocket No Hit N/A —
5320 PA4731 aspartate alpha-decarboxylase panD, PA4731 AlphaFold
4.1.1.11
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004068Catalysis of the reaction: L-aspartate = beta-alanine + CO2. GO:0006523The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid. +14 total
No pocket No Hit N/A —
5321 PA3496 hypothetical protein PA3496 AlphaFold – – No pocket No Hit N/A —
5322 PA1571 hypothetical protein PA1571 AlphaFold – – No pocket No Hit N/A —
5323 PA2279 low molecular weight phosphatase PA2279, arsC, arsC_4 AlphaFold –
GO:0046685Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
No pocket No Hit N/A —
5324 PA3979 hypothetical protein PA3979 AlphaFold – – No pocket No Hit N/A —
5325 PA3572 hypothetical protein PA3572 AlphaFold – – No pocket No Hit N/A —
Page of 223 · 5572 total proteins