Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5276 PA1041 hypothetical protein PA1041 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.233 No Hit N/A —
5277 PA1769 phosphoenolpyruvate synthase regulatory protein PA1769 AlphaFold
2.7.11.33 2.7.4.28
GO:0043531Binding to ADP, adenosine 5'-diphosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004721Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. +47 total
0.232 No Hit N/A —
5278 PA0329 hypothetical protein PA0329 AlphaFold –
GO:0006302The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
0.231 No Hit N/A —
5279 PA3960 hypothetical protein PA3960 AlphaFold – – 0.229 No Hit N/A —
5280 PA3903 peptide chain release factor 3 prfC, PA3903 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005525Binding to GTP, guanosine triphosphate. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. +69 total
0.229 Hit 42.9% 6.74e-07
5281 PA3223 FMN-dependent NADH-azoreductase PA3223, azoR3 AlphaFold
1.6.5.- 1.7.1.17
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016652Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP. +25 total
0.229 Hit 31.5% 5.76e-06
5282 PA3115 motility protein FimV fimV, PA3115 Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0044096A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers. +25 total
0.228 No Hit N/A —
5283 PA4478 hypothetical protein PA4478 AlphaFold
3.6.1.9
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0036218Catalysis of the reaction: dTTP + H2O = dTMP + H+ + diphosphate. GO:0047429Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. +25 total
0.226 Hit 39.2% 1.30e-30
5284 PA5281 hydrolase PA5281 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
0.223 Hit 49.1% 1.15e-07
5285 PA5240 thioredoxin PA5240, trxA, trx AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. +14 total
0.222 Hit 37.3% 1.15e-14
5286 PA4397 2-dehydropantoate 2-reductase panE, PA4397 Experimental + AlphaFold
1.1.1.169
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008677Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + H+ + NADPH. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. +25 total
0.222 No Hit N/A —
5287 PA3204 two-component response regulator PA3204 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +47 total
0.22 No Hit N/A —
5288 PA3152 imidazole glycerol phosphate synthase subunit HisH hisH, PA3152, hisH2 AlphaFold
4.3.2.10 3.5.1.2
GO:0009382Complex that possesses imidazoleglycerol-phosphate synthase activity. GO:0004359Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH4+. GO:0000107Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. +47 total
0.22 No Hit N/A —
5289 PA1204 NAD(P)H-dependent FMN reductase PA1204 Experimental + AlphaFold
1.-.-.-
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0052873Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+. +58 total
0.219 No Hit N/A —
5290 PA4404 hypothetical protein PA4404, mepM_1 AlphaFold –
GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
0.217 No Hit N/A —
5291 PA0664 hypothetical protein PA0664 AlphaFold – – 0.217 No Hit N/A —
5292 PA0263 secreted protein Hcp PA5267, hcpB, hcpC, hcpA Experimental + AlphaFold – – 0.217 No Hit N/A —
5293 PA0357 formamidopyrimidine-DNA glycosylase PA0357, mutM, fpg AlphaFold
3.2.2.23 4.2.99.18
GO:0034039Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. GO:0140078Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate. GO:0003684Binding to damaged DNA. +1013 total
0.216 No Hit N/A —
5294 PA4740 polynucleotide phosphorylase PA4740, pnp AlphaFold
2.7.7.8
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000175Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. GO:0000287Binding to a magnesium (Mg) ion. +69 total
0.215 Hit 44.3% 1.46e-06
5295 PA4623 hypothetical protein PA4623 AlphaFold – – 0.215 No Hit N/A —
5296 PA4421 cell division protein MraZ PA4421, mraZ AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009295The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +47 total
0.213 No Hit N/A —
5297 PA4384 hypothetical protein PA4384 AlphaFold – – 0.213 No Hit N/A —
5298 PA0075 serine/threonine phosphatase PA0075, pppA Experimental + AlphaFold –
GO:0046872Binding to a metal ion. GO:0004722Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. GO:0050709Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. +25 total
0.212 No Hit N/A —
5299 PA3616 recombination regulator RecX recX, PA3616 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006282Any process that modulates the frequency, rate or extent of DNA repair. GO:0009432An error-prone process for repairing damaged microbial DNA.
0.211 No Hit N/A —
5300 PA5452 phosphomannose isomerase/mannose-1-phosphate guanylyl transferase wbpW, PA5452 AlphaFold
2.7.7.13 5.3.1.8
GO:0005525Binding to GTP, guanosine triphosphate. GO:0004475Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose. GO:0004476Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. +811 total
0.204 No Hit N/A —
Page of 223 · 5572 total proteins