Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5351 PA2582 hypothetical protein PA2582 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0033592An activity that facilitates the formation of a complementary double-stranded RNA molecule. GO:0034057Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity. +25 total
No pocket No Hit N/A —
5352 PA0320 hypothetical protein PA0320, carO AlphaFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0055074Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell. GO:0071585Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion. +47 total
No pocket No Hit N/A —
5353 PA1849 hypothetical protein PA1849 AlphaFold – – No pocket No Hit N/A —
5354 PA4877 hypothetical protein PA4877 AlphaFold –
GO:0006353The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template.
No pocket No Hit N/A —
5355 PA3374 hypothetical protein PA3374 AlphaFold –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0019700The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.
No pocket No Hit N/A —
5356 PA0690 hypothetical protein PA0690 UnavailableNo structure available — sequence may exceed the prediction length limit –
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0098046A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc). GO:0046819The process in which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway.
No structure No structure No structure No structure
5357 PA1881 oxidoreductase PA1881 AlphaFold –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
No pocket Hit 36.8% 2.90e-15
5358 PA1592 hypothetical protein PA1592 AlphaFold – – No pocket No Hit N/A —
5359 PA3291 hypothetical protein PA3291 AlphaFold – – No pocket No Hit N/A —
5360 PA2883 hypothetical protein PA2883 AlphaFold – – No pocket No Hit N/A —
5361 PA5555 ATP synthase subunit gamma PA5555, atpG AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0045259A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
No pocket Hit 29.9% 8.24e-28
5362 PA5274 nucleoside diphosphate kinase regulator PA5274, rnk AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0070063Binding to an RNA polymerase molecule or complex. +25 total
No pocket No Hit N/A —
5363 PA0778 inhibitor of cysteine peptidase PA0778, icp AlphaFold –
GO:0004869Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase. GO:0030162Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
No pocket No Hit N/A —
5364 PA3214 hypothetical protein PA3214 AlphaFold – – No pocket No Hit N/A —
5365 PA2118a hypothetical protein ColabFold – – No pocket No Hit N/A —
5366 PA0713 hypothetical protein PA0713 AlphaFold – – No pocket No Hit N/A —
5367 PA4586 hypothetical protein PA4586 AlphaFold – – No pocket No Hit N/A —
5368 PA4636a hypothetical protein ColabFold – – No pocket No Hit N/A —
5369 PA4245 50S ribosomal protein L30 PA4245, rpmD AlphaFold –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
No pocket No Hit N/A —
5370 PA1664 hypothetical protein PA1664 AlphaFold –
GO:0033103The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
No pocket No Hit N/A —
5371 PA3276 hypothetical protein PA3276 AlphaFold – – No pocket No Hit N/A —
5372 PA4840 translation initiation factor Sui1 PA4840 AlphaFold –
GO:0003743Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. GO:0001731The joining of the small ribosomal subunit, ternary complex, and mRNA. GO:0006417Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. +25 total
No pocket No Hit N/A —
5373 PA1394 hypothetical protein PA1394 AlphaFold – – No pocket No Hit N/A —
5374 PA0060 hypothetical protein PA0060 AlphaFold – – No pocket No Hit N/A —
5375 PA3334 acyl carrier protein PA3334 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0000035Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid. +25 total
No pocket No Hit N/A —
Page of 223 · 5572 total proteins