Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
676 PA1977 hypothetical protein PA1977 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0033228The directed movement of cysteine from inside of a cell, across the plasma membrane and into the extracellular region. +14 total
0.908 No Hit N/A —
677 PA1892 hypothetical protein PA1892 AlphaFold – – 0.908 No Hit N/A —
678 PA1736 acetyl-CoA acetyltransferase PA1736 AlphaFold –
GO:0003985Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.908 Hit 45.9% 4.46e-21
679 PA1734 hypothetical protein PA1734 AlphaFold –
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0046872Binding to a metal ion.
0.908 No Hit N/A —
680 PA1477 heme exporter protein CcmC ccmC, PA1477 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004096Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +912 total
0.908 No Hit N/A —
681 PA1188 hypothetical protein PA1188 AlphaFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.908 Hit 45.8% 1.66e-30
682 PA0808 hypothetical protein PA0808 AlphaFold – – 0.908 No Hit N/A —
683 PA0561 hypothetical protein PA0561 AlphaFold – – 0.908 No Hit N/A —
684 PA0027 hypothetical protein PA0027 AlphaFold
5.2.1.8
GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
0.908 No Hit N/A —
685 PA5537 hypothetical protein PA5537 AlphaFold – – 0.907 No Hit N/A —
686 PA5208 hypothetical protein PA5208 AlphaFold –
GO:0071978Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria. GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
0.907 No Hit N/A —
687 PA3568 propionyl-CoA synthetase PA3568 AlphaFold –
GO:0070013An organelle lumen that is part of an intracellular organelle. GO:0050218Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA.
0.907 Hit 55.4% 1.04e-31
688 PA2966 acyl carrier protein acpP1, acpP, PA2966 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0000035Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid. +47 total
0.907 Hit 51.9% 3.35e-13
689 PA2196 transcriptional regulator PA2196 Experimental + AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.907 No Hit N/A —
690 PA1259 hypothetical protein PA1259, lhpI AlphaFold
4.2.1.171
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0019470The chemical reactions and pathways resulting in the breakdown of trans-4-hydroxy-L-proline.
0.907 No Hit N/A —
691 PA5008 hypothetical protein PA5008, wapP, rfaP_1 AlphaFold –
GO:0004672Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. GO:0009244The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. GO:0006468The process of introducing a phosphate group on to a protein.
0.906 No Hit N/A —
692 PA4876 OsmE family transcriptional regulator osmE, PA4876 Experimental + AlphaFold –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
0.906 No Hit N/A —
693 PA4867 urease subunit beta PA4867, ureB AlphaFold
3.5.1.5
GO:0035550A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide). GO:0009039Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+. GO:0043419The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2.
0.906 No Hit N/A —
694 PA4194 ABC transporter permease PA4194 AlphaFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +47 total
0.906 No Hit N/A —
695 PA3967 hypothetical protein PA3967 Experimental + AlphaFold –
GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0046872Binding to a metal ion. GO:0019825Binding to oxygen (O2). +14 total
0.906 No Hit N/A —
696 PA3682 hypothetical protein PA3682 AlphaFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0046872Binding to a metal ion. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.906 No Hit N/A —
697 PA3293 hypothetical protein PA3293 AlphaFold – – 0.906 No Hit N/A —
698 PA3176 glutamate/sodium ion symporter GltS gltS, PA3176 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015501Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). GO:0015813The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore. +14 total
0.906 No Hit N/A —
699 PA3046 hypothetical protein PA3046 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.906 No Hit N/A —
700 PA1972 hypothetical protein PA1972 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016776Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). GO:0009244The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. +36 total
0.906 No Hit N/A —
Page of 223 · 5572 total proteins