Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
701 PA1595 hypothetical protein PA1595 AlphaFold – – 0.906 No Hit N/A —
702 PA1540 multidrug efflux system protein MdtI PA1540 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015199Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid. GO:0015297Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). +710 total
0.906 No Hit N/A —
703 PA1144 major facilitator superfamily transporter PA1144 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.906 Hit 34.1% 4.95e-13
704 PA0990 hypothetical protein PA0990 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.906 Hit 28.2% 2.55e-06
705 PA0841 hypothetical protein PA0841 AlphaFold –
GO:0008289Binding to a lipid.
0.906 No Hit N/A —
706 PA0592 ribosomal RNA small subunit methyltransferase A rsmA, PA0592, ksgA AlphaFold
2.1.1.182
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0052908Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA. GO:0003723Binding to an RNA molecule or a portion thereof. +58 total
0.906 Hit 35.5% 1.53e-31
707 PA0471 transmembrane sensor PA0471 AlphaFold –
GO:0016989The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity. GO:0034756Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.906 No Hit N/A —
708 PA0338 hypothetical protein PA0338 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0061939Any process that mediates the transfer of information from one cell to another using c-di-GMP as the signal. +14 total
0.906 No Hit N/A —
709 PA0305 hypothetical protein PA0305 AlphaFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0046872Binding to a metal ion. +25 total
0.906 No Hit N/A —
710 PA5381 hypothetical protein PA5381 AlphaFold – – 0.905 No Hit N/A —
711 PA4801 hypothetical protein PA4801 AlphaFold – – 0.905 No Hit N/A —
712 PA4783 hypothetical protein PA4783 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.905 No Hit N/A —
713 PA4357 hypothetical protein PA4357 AlphaFold – – 0.905 No Hit N/A —
714 PA4265 elongation factor Tu tufB, PA4277, tufA Experimental + AlphaFold –
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0006414The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. +14 total
0.905 Hit 81.8% 1.19e-10
715 PA3865a hypothetical protein ColabFold – – 0.905 No Hit N/A —
716 PA3041 hypothetical protein PA3041 AlphaFold – – 0.905 No Hit N/A —
717 PA2647 NADH-quinone oxidoreductase subunit L PA2647, nuoL AlphaFold
7.1.1.-
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0045271Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex. GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). +36 total
0.905 Hit 39.3% 4.73e-78
718 PA1785 hypothetical protein PA1785 AlphaFold –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0090352Any process that modulates the rate, frequency, or extent of the uptake, from the environment, of nitrates, inorganic or organic salts and esters of nitric acid and the subsequent reduction of nitrate ion to other, less highly oxidized, inorganic nitrogenous substances.
0.905 No Hit N/A —
719 PA0255 hypothetical protein PA0255 AlphaFold – – 0.905 No Hit N/A —
720 PA0235 4-hydroxybenzoate transporter PcaK pcaK, PA0235 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). +25 total
0.905 Hit 32.4% 9.13e-13
721 PA5484 two-component sensor PA5484 Experimental + AlphaFold
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. +58 total
0.904 No Hit N/A —
722 PA4413 cell division protein FtsW ftsW, PA4413 AlphaFold
2.4.99.28
GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015648Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells. +710 total
0.904 No Hit N/A —
723 PA4142 secretion protein PA4142 AlphaFold – – 0.904 No Hit N/A —
724 PA3512 ABC transporter permease PA3512 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.904 No Hit N/A —
725 PA2527 resistance-nodulation-cell division (RND) efflux transporter PA2527 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
0.904 No Hit N/A —
Page of 223 · 5572 total proteins