Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
726 PA2521 resistance-nodulation-cell division (RND) divalent metal cation efflux membrane fusion protein CzcB PA2521, czcB AlphaFold –
GO:0030313An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +69 total
0.904 No Hit N/A —
727 PA1764 hypothetical protein PA1764 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015483Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
0.904 No Hit N/A —
728 PA1383 hypothetical protein PA1383 AlphaFold – – 0.904 No Hit N/A —
729 PA1358 hypothetical protein PA1358 Experimental + AlphaFold – – 0.904 No Hit N/A —
730 PA0951 hypothetical protein PA0951 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.904 No Hit N/A —
731 PA0273 major facilitator superfamily transporter PA0273 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0009440The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid. +14 total
0.904 No Hit N/A —
732 PA5386 3-hydroxybutyryl-CoA dehydrogenase cdhA, PA5386 AlphaFold
1.1.1.108
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0047728Catalysis of the reaction: carnitine + NAD+ = 3-dehydrocarnitine + H+ + NADH. GO:0070403Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. +47 total
0.903 Hit 40.5% 9.18e-25
733 PA5114 hypothetical protein PA5114 AlphaFold – – 0.903 No Hit N/A —
734 PA4754 hypothetical protein PA4754 AlphaFold – – 0.903 No Hit N/A —
735 PA4095 hypothetical protein PA4095 AlphaFold – – 0.903 No Hit N/A —
736 PA4052 transcription antitermination protein NusB nusB, PA4052 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006353The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template. +25 total
0.903 No Hit N/A —
737 PA3796 hypothetical protein PA3796 AlphaFold – – 0.903 No Hit N/A —
738 PA3789 hypothetical protein PA3789 AlphaFold – – 0.903 No Hit N/A —
739 PA3649 zinc metalloprotease PA3649, mucP Experimental + AlphaFold
3.4.24.-
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004175Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. GO:0046872Binding to a metal ion. +47 total
0.903 No Hit N/A —
740 PA3133 transcriptional regulator PA3133 Experimental + AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0048023Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin.
0.903 No Hit N/A —
741 PA2701 major facilitator superfamily transporter PA2701 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. +14 total
0.903 No Hit N/A —
742 PA2472 major facilitator superfamily transporter PA2472 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046943Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). GO:0046942The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). +36 total
0.903 Hit 38.0% 3.04e-06
743 PA1888 hypothetical protein PA1888 AlphaFold – – 0.903 No Hit N/A —
744 PA0005 lysophosphatidic acid acyltransferase lptA, PA0005 AlphaFold
2.3.1.51
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003841Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. GO:0042171Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid. +47 total
0.903 Hit 32.0% 2.02e-18
745 PA4376 nicotinate phosphoribosyltransferase pncB2, PA4376 Experimental + AlphaFold
6.3.4.21
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004516Catalysis of the reaction: nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate. GO:0034355The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide (NAD+) from vitamin B3 derivatives (including nicotinic acid (NA) and nicotinamide (NAM)), beta-nicotinamide D-ribonucleotide (NMN), nicotinamide riboside (NR) or nicotinate riboside (NAR), without de novo synthesis. +14 total
0.902 No Hit N/A —
746 PA4096 major facilitator superfamily transporter PA4096 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.902 Hit 25.8% 2.30e-09
747 PA3984 apolipoprotein N-acyltransferase PA3984, lnt, cutE Experimental + AlphaFold
2.3.1.269
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016410Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. GO:0042158The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. +25 total
0.902 No Hit N/A —
748 PA3894 hypothetical protein PA3894 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. +25 total
0.902 No Hit N/A —
749 PA3837 ABC transporter permease PA3837 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
0.902 No Hit N/A —
750 PA3406 transporter HasD hasD, PA3406 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0030256A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. +69 total
0.902 Hit 43.8% 3.84e-15
Page of 223 · 5572 total proteins