Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1576 PA3023 lipid kinase PA3023 AlphaFold
2.7.1.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +710 total
0.836 No Hit N/A —
1577 PA2441 hypothetical protein PA2441 AlphaFold – – 0.836 No Hit N/A —
1578 PA2099 short-chain dehydrogenase PA2099 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.836 Hit 35.0% 4.25e-15
1579 PA2087 hypothetical protein PA2087 AlphaFold – – 0.836 No Hit N/A —
1580 PA1617 AMP-binding protein PA1617 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016405Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA.
0.836 Hit 34.2% 7.82e-30
1581 PA0190 acid phosphatase PA0190 AlphaFold
3.1.3.2
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0003993Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.
0.836 No Hit N/A —
1582 PA0094 hypothetical protein eagT6, PA0094 Experimental + AlphaFold – – 0.836 No Hit N/A —
1583 PA0035 tryptophan synthase subunit alpha PA0035, trpA AlphaFold
4.2.1.20
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004834Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. GO:0000162The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate. +14 total
0.836 No Hit N/A —
1584 PA5077 glucosyltransferase MdoH opgH, mdoH, PA5077 AlphaFold
2.4.1.-
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016758Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). GO:0030244The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. +14 total
0.835 No Hit N/A —
1585 PA4923 hypothetical protein PA4923 Experimental + AlphaFold
3.2.2.n1 3.2.2.4
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008714Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine. GO:0102682Catalysis of the reaction: N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O = N(6)-dimethylallyladenine + D-ribose 5-phosphate. +36 total
0.835 No Hit N/A —
1586 PA4222 ABC transporter ATP-binding protein PA4222 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
0.835 Hit 39.9% 1.10e-36
1587 PA3732 hypothetical protein ColabFold – – 0.835 No Hit N/A —
1588 PA3581 glycerol uptake facilitator protein glpF, PA3581 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015254Enables the energy-independent facilitated diffusion of glycerol through a transmembrane aqueous pore or channel. GO:0015793The directed movement of glycerol across a membrane. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. +36 total
0.835 Hit 43.3% 6.74e-50
1589 PA3127 hypothetical protein PA3127 AlphaFold –
GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.835 No Hit N/A —
1590 PA2754a hypothetical protein ColabFold – – 0.835 No Hit N/A —
1591 PA2729 hypothetical protein PA2729 AlphaFold – – 0.835 No Hit N/A —
1592 PA2660 hypothetical protein PA2660 AlphaFold – – 0.835 No Hit N/A —
1593 PA2413 diaminobutyrate--2-oxoglutarate aminotransferase PA2413, pvdH AlphaFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0002049The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine. +25 total
0.835 Hit 28.8% 1.53e-42
1594 PA2287 hypothetical protein PA2287 AlphaFold – – 0.835 No Hit N/A —
1595 PA2006 major facilitator superfamily transporter PA2006 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046943Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). GO:0046942The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). +36 total
0.835 Hit 32.5% 1.88e-06
1596 PA1856 cbb3-type cytochrome C oxidase subunit I PA1856 AlphaFold
7.1.1.9
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004129Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out). GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +69 total
0.835 No Hit N/A —
1597 PA1551 ferredoxin PA1551 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +25 total
0.835 No Hit N/A —
1598 PA1534 recombination protein RecR PA1534, recR Experimental + AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0008270Binding to a zinc ion (Zn). GO:0006302The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. +47 total
0.835 No Hit N/A —
1599 PA5392 hypothetical protein PA5392 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).
0.834 Hit 35.2% 2.34e-11
1600 PA5349 rubredoxin reductase alkT, PA5349 Experimental + AlphaFold
1.18.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +36 total
0.834 Hit 22.8% 6.22e-06
Page of 223 · 5572 total proteins