Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2351 PA5511 DNA-binding response regulator MifR mifR, PA5511 AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. +811 total
0.769 No Hit N/A —
2352 PA5328 mono-heme cytochrome C PA5328 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +25 total
0.769 No Hit N/A —
2353 PA5070 transporter TatC PA5070, tatC AlphaFold –
GO:0033281A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins. GO:0008320Enables the transfer of a protein from one side of a membrane to the other. GO:0009977Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane. +36 total
0.769 No Hit N/A —
2354 PA5004 glycosyl transferase family protein PA5004 AlphaFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:1901135The chemical reactions and pathways involving carbohydrate derivative.
0.769 No Hit N/A —
2355 PA4252 50S ribosomal protein L24 rplX, PA4252 AlphaFold –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0019843Binding to a ribosomal RNA. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +36 total
0.769 No Hit N/A —
2356 PA4164 hypothetical protein PA4164 AlphaFold – – 0.769 No Hit N/A —
2357 PA3937 taurine ABC transporter ATP-binding protein PA3937, tauB AlphaFold
7.6.2.7
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015411Enables the transfer of taurine from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
0.769 Hit 36.5% 1.51e-06
2358 PA3125 hypothetical protein PA3125 AlphaFold –
GO:0016788Catalysis of the hydrolysis of any ester bond.
0.769 No Hit N/A —
2359 PA2839 hypothetical protein PA2839 AlphaFold –
GO:0008198Binding to a ferrous iron ion, Fe(II). GO:0016702Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. GO:0008270Binding to a zinc ion (Zn). +36 total
0.769 No Hit N/A —
2360 PA2614 outer-membrane lipoprotein carrier protein lolA, PA2614 Experimental + AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0044874A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane. GO:0042953The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
0.769 No Hit N/A —
2361 PA2271 acetyltransferase PA2271 Experimental + AlphaFold
2.3.1.-
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.769 No Hit N/A —
2362 PA2063 hypothetical protein PA2063 AlphaFold – – 0.769 No Hit N/A —
2363 PA1970 hypothetical protein PA1970 AlphaFold – – 0.769 No Hit N/A —
2364 PA0659 hypothetical protein PA0659 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.769 No Hit N/A —
2365 PA0461 acyltransferase PA0461 AlphaFold –
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
0.769 Hit 27.9% 6.94e-12
2366 PA0171 hypothetical protein PA0171 Experimental + AlphaFold –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.769 No Hit N/A —
2367 PA0170 hypothetical protein PA0170 Experimental + AlphaFold – – 0.769 No Hit N/A —
2368 PA5093 histidine/phenylalanine ammonia-lyase PA5093 AlphaFold –
GO:0004397Catalysis of the reaction: L-histidine = trans-urocanate + NH4+. GO:0006548The chemical reactions and pathways resulting in the breakdown of L-histidine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.768 Hit 44.1% 2.86e-31
2369 PA4551 type 4 fimbrial biogenesis protein PilV PA4551, pilV AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0044096A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers. GO:0009297The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. +25 total
0.768 No Hit N/A —
2370 PA4346 hypothetical protein PA4346 AlphaFold – – 0.768 No Hit N/A —
2371 PA3978 hypothetical protein PA3978, podJ_2 AlphaFold –
GO:0005515Binding to a protein.
0.768 Hit 32.3% 4.40e-07
2372 PA3943 hypothetical protein PA3943 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.768 No Hit N/A —
2373 PA3776 transcriptional regulator PA3776 AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.768 No Hit N/A —
2374 PA3553 undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase arnC, PA3553 AlphaFold
2.4.2.53
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016780Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). GO:0099621Catalysis of the reaction: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate. +58 total
0.768 Hit 34.0% 1.58e-10
2375 PA3040 hypothetical protein PA3040 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0043022Binding to a ribosome.
0.768 No Hit N/A —
Page of 223 · 5572 total proteins