Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5192 proteins Structure: AlphaFold

Scoring formula None

Sorted by Druggability (descending)

Applied filters Structure: AlphaFold

Search query No active search

Rows per page 25

Rows
Active criteria 1
Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4476 KP13_31878 Lipoprotein spr spr AlphaFold + ColabFold
3.4.17.13 3.4.-.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008234Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. GO:0106415GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H2O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine. +14 total
0.224 No Hit 0.0% —
4477 KP13_04924 Maf-like protein AlphaFold + ColabFold
3.6.1.-
GO:0047429Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009117The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).
0.224 Hit 30.8% 7.36e-12
4478 KP13_03111 putative transposase AlphaFold + ColabFold –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.224 No Hit 0.0% —
4479 KP13_31952 putative transposase AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
0.223 No Hit 0.0% —
4480 KP13_05596 putative oxidoreductase AlphaFold + ColabFold
1.3.1.104
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0141148Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NADP+ = a (2E)-enoyl-[ACP] + H+ + NADPH. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
0.223 Hit 28.4% 4.77e-25
4481 KP13_05468 ABC superfamily ATP binding cassette transporter AlphaFold + ColabFold –
GO:0009228The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
0.223 No Hit 0.0% —
4482 KP13_04648 hypothetical protein AlphaFold + ColabFold – – 0.223 No Hit 0.0% —
4483 KP13_04312 Glutamine transport ATP-binding protein glnQ glnQ AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003333The process in which an amino acid is transported across a membrane. +14 total
0.223 Hit 61.1% 7.30e-07
4484 KP13_05313 Gluconate 2-dehydrogenase subunit 3 AlphaFold + ColabFold – – 0.222 No Hit 0.0% —
4485 KP13_04809 hypothetical protein AlphaFold + ColabFold – – 0.222 No Hit 0.0% —
4486 KP13_03589 Cysteinyl-tRNA synthetase cysS AlphaFold + ColabFold
6.1.1.16
GO:0006423The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +69 total
0.222 Hit 56.0% 1.66e-25
4487 KP13_02772 Biopolymer transport protein exbD exbD AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +36 total
0.222 No Hit 0.0% —
4488 KP13_00082 Acetolactate synthase isozyme 1 small subunit ilvN AlphaFold + ColabFold
2.2.1.6
GO:1990610Binds to and modulates the activity of acetolactate synthase. GO:0009082The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.222 No Hit 0.0% —
4489 KP13_32182 Protein hfq hfq AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.221 No Hit 0.0% —
4490 KP13_04752 HPP family protein AlphaFold + ColabFold – – 0.221 No Hit 0.0% —
4491 KP13_03880 Heat shock protein hspQ hspQ AlphaFold + ColabFold –
GO:0009408Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.221 No Hit 0.0% —
4492 KP13_03713 Cation efflux system protein cusF cusF AlphaFold + ColabFold – – 0.221 No Hit 0.0% —
4493 KP13_03413 putative lipoprotein AlphaFold + ColabFold – – 0.221 No Hit 0.0% —
4494 KP13_03155 putative lipid kinase AlphaFold + ColabFold
2.7.1.-
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0001727Catalysis of the phosphorylation of a simple or complex lipid. +69 total
0.221 Hit 28.2% 8.76e-07
4495 KP13_01433 replication initiation protein RepC repC AlphaFold + ColabFold – – 0.221 No Hit 0.0% —
4496 KP13_00902 hypothetical protein AlphaFold + ColabFold – – 0.221 No Hit 0.0% —
4497 KP13_00866 putative oxidoreductase AlphaFold + ColabFold –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.221 No Hit 0.0% —
4498 KP13_00796 CDP-diacylglycerol--serine O-phosphatidyltransferase pssA AlphaFold + ColabFold –
GO:0032049The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008444Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H+. +25 total
0.221 Hit 27.7% 2.25e-07
4499 KP13_05632 Transcriptional repressor protein, KorB AlphaFold + ColabFold –
GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0007059The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. GO:0045881Any process that activates or increases the frequency, rate or extent of sporulation.
0.22 No Hit 0.0% —
4500 KP13_04864 tRNA-specific 2-thiouridylase mnmA mnmA AlphaFold + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. GO:0016783Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).
0.22 Hit 54.6% 1.05e-31
Page of 208 · 5192 total proteins