Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4776 KP13_04078 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.123 0.316 No Hit 0.0% —
4777 KP13_03837 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.123 0.798 No Hit 0.0% —
4778 KP13_03504 putative extracellular solute-binding protein AlphaFold DB model + ColabFold model –
GO:0071705The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
No map 0.123 0.295 No Hit 0.0% —
4779 KP13_01958 Protein apaG apaG AlphaFold DB model + ColabFold model –
GO:0070987The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.
No map 0.123 0.271 Hit 43.2% 2.11e-12
4780 KP13_00486 Divalent-cation tolerance protein cutA cutA AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005507Binding to a copper (Cu) ion. GO:0010038Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
No map 0.123 0.035 Hit 40.5% 8.45e-16
4781 KP13_31933 Protein dsrB dsrB AlphaFold DB model + ColabFold model – – No map N/A 0.122 No Hit 0.0% —
4782 KP13_31614 Insertion element iso-IS1d protein insB AlphaFold DB model + ColabFold model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.122 0.359 No Hit 0.0% —
4783 KP13_04340 OmpA/MotB domain-containing protein Experimental + AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
No map 0.122 0.656 No Hit 0.0% —
4784 KP13_02580 Hydrogenase 3 maturation protease hycI AlphaFold DB model + ColabFold model –
GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0008047A molecular function regulator that increases a catalytic activity. GO:0004175Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. +14 total
No map 0.122 0.193 No Hit 0.0% —
4785 KP13_02550 Iron transport system permease component SitD sitD AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +47 total
No map 0.122 0.628 No Hit 0.0% —
4786 KP13_01800 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase lpxD AlphaFold DB model + ColabFold model
2.3.1.191
GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. GO:0016410Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. +36 total
No map 0.122 0.707 No Hit 0.0% —
4787 KP13_02433 Protein rnfH rnfH AlphaFold DB model + ColabFold model – – No map N/A 0.121 No Hit 0.0% —
4788 KP13_31554 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.120 0.315 No Hit 0.0% —
4789 KP13_05124 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.120 0.446 No Hit 0.0% —
4790 KP13_05089 Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A lpsI AlphaFold DB model + ColabFold model –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
No map 0.120 0.676 Hit 60.0% 8.31e-33
4791 KP13_04469 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.12 No Hit 0.0% —
4792 KP13_03588 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0003723Binding to an RNA molecule or a portion thereof.
No map N/A 0.12 No Hit 0.0% —
4793 KP13_02600 putative ABC transporter metal-binding lipoprotein Experimental + ColabFold model –
GO:0030001The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0046872Binding to a metal ion. +14 total
No map 0.120 0.193 No Hit 0.0% —
4794 KP13_00453 Protein phnJ phnJ AlphaFold DB model + ColabFold model –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0019700The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.
No map 0.120 0.282 No Hit 0.0% —
4795 KP13_31945 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.119 No Hit 0.0% —
4796 KP13_31587 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.119 0.26 No Hit 0.0% —
4797 KP13_05624 transcriptional repressor protein KorB korB AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0007059The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
No map 0.119 0.383 No Hit 0.0% —
4798 KP13_05003 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.119 0.279 No Hit 0.0% —
4799 KP13_04112 Protein nrdI nrdI AlphaFold DB model + ColabFold model –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
No map 0.119 0.67 No Hit 0.0% —
4800 KP13_03732 Signal peptidase S49 AlphaFold DB model + ColabFold model
3.4.21.-
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
No map 0.119 0.313 No Hit 0.0% —
Page of 234 · 5842 total proteins