Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4876 KP13_31933 Protein dsrB dsrB AlphaFold + ColabFold – – 0.122 No Hit 0.0% —
4877 KP13_00345 HTH transcriptional regulator, GntR protein AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. +36 total
0.122 Hit 23.6% 9.47e-19
4878 KP13_06746 hypothetical protein AlphaFold + ColabFold – – 0.121 No Hit 0.0% —
4879 KP13_02433 Protein rnfH rnfH AlphaFold + ColabFold – – 0.121 No Hit 0.0% —
4880 KP13_01549 Alanine racemase, catabolic dadB AlphaFold + ColabFold
5.1.1.1
GO:0006522OBSOLETE. The chemical reactions and pathways involving alanine, 2-aminopropanoic acid. GO:0008784Catalysis of the reaction: L-alanine = D-alanine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +47 total
0.121 No Hit 0.0% —
4881 KP13_00973 2-succinylbenzoate--CoA ligase menE AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008756Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate. GO:0009234The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2.
0.121 Hit 31.0% 3.20e-12
4882 KP13_04883 Glucitol/sorbitol-specific phosphotransferase enzyme IIA component AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +14 total
0.12 No Hit 0.0% —
4883 KP13_04469 hypothetical protein AlphaFold + ColabFold – – 0.12 No Hit 0.0% —
4884 KP13_03969 putative transposase AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0046872Binding to a metal ion. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. +14 total
0.12 No Hit 0.0% —
4885 KP13_03588 hypothetical protein AlphaFold + ColabFold –
GO:0003723Binding to an RNA molecule or a portion thereof.
0.12 No Hit 0.0% —
4886 KP13_01001 hypothetical protein AlphaFold + ColabFold – – 0.12 No Hit 0.0% —
4887 KP13_31945 hypothetical protein AlphaFold + ColabFold – – 0.119 No Hit 0.0% —
4888 KP13_04530 hypothetical protein AlphaFold + ColabFold –
GO:0006276The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division. GO:0008657Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
0.119 No Hit 0.0% —
4889 KP13_00200 Lipopolysaccharide heptosyltransferase 1 rfaC AlphaFold + ColabFold
2.4.99.23
GO:0009244The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0008920Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+. +36 total
0.118 No Hit 0.0% —
4890 KP13_32213 Inositol-1-monophosphatase AlphaFold + ColabFold –
GO:0008934Catalysis of the reaction: 1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. GO:0046872Binding to a metal ion. GO:0006020The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. +14 total
0.117 Hit 34.9% 3.05e-09
4891 KP13_05072 hypothetical protein AlphaFold + ColabFold – – 0.117 No Hit 0.0% —
4892 KP13_03952 Glyoxalase/bleomycin resistance protein/dioxygenase AlphaFold + ColabFold –
GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
0.117 No Hit 0.0% —
4893 KP13_02542 Hemin-binding periplasmic protein HmuT hmuT AlphaFold + ColabFold – – 0.117 No Hit 0.0% —
4894 KP13_31497 Orotate phosphoribosyltransferase pyrE AlphaFold + ColabFold
2.4.2.10
GO:0004588Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. GO:0006221The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
0.116 Hit 31.2% 3.16e-08
4895 KP13_03285 Pyrrolidone-carboxylate peptidase pcp AlphaFold + ColabFold
3.4.19.3
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0016920Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.116 Hit 29.4% 1.14e-13
4896 KP13_02997 Transcriptional regulator modE modE AlphaFold + ColabFold –
GO:0030151Binding to a molybdenum ion (Mo). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
0.116 No Hit 0.0% —
4897 KP13_02856 putative aldolase LsrF lsrF AlphaFold + ColabFold –
GO:0004332Catalysis of the reaction: beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
0.116 No Hit 0.0% —
4898 KP13_00739 Protein tusB tusB AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0002143The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
0.116 No Hit 0.0% —
4899 KP13_03902 Gamma-glutamylputrescine synthetase puuA AlphaFold + ColabFold –
GO:0004356Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. +36 total
0.115 Hit 25.7% 2.51e-20
4900 KP13_01111 Ribosomal RNA large subunit methyltransferase E rlmE AlphaFold + ColabFold
2.1.1.166
GO:0001510Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. +47 total
0.115 Hit 40.5% 1.45e-15
Page of 208 · 5192 total proteins