Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
801 KP13_03163 D-arabinitol transporter dalT AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.876 No Hit 0.0% —
802 KP13_02785 AraC family transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.876 No Hit 0.0% —
803 KP13_02501 4-hydroxyphenylacetate 3-monooxygenase oxygenase component hpaB AlphaFold + ColabFold
1.14.14.9
GO:0016712Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate. +25 total
0.876 No Hit 0.0% —
804 KP13_02160 Phosphoglycerate kinase pgk AlphaFold + ColabFold –
GO:0004618Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H+. GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
0.876 Hit 38.0% 6.91e-76
805 KP13_05039 Pca regulon regulatory protein AlphaFold + ColabFold –
GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0046278The chemical reactions and pathways involving protocatechuate, the anion of protocatechuic acid (3,4-dihydroxybenzoic acid). +14 total
0.875 No Hit 0.0% —
806 KP13_02853 putative HTH-type transcriptional regulator AlphaFold + ColabFold – – 0.875 No Hit 0.0% —
807 KP13_01118 hypothetical protein AlphaFold + ColabFold
2.5.1.1 2.5.1.10 2.5.1.29 +14 total
GO:0004337Catalysis of the reaction: (2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate. GO:0106350Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate. GO:0004161Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = (2E)-geranyl diphosphate + diphosphate. +14 total
0.875 No Hit 0.0% —
808 KP13_32006 putative oxidoreductase AlphaFold + ColabFold –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.874 Hit 43.1% 5.23e-08
809 KP13_31826 UDP-N-acetylmuramate--L-alanine ligase murC AlphaFold + ColabFold
6.3.2.8
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0016881Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. +69 total
0.874 No Hit 0.0% —
810 KP13_04892 N-acetyl-D-glucosamine kinase nagK AlphaFold + ColabFold
2.7.1.59
GO:0045127Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + H+. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008270Binding to a zinc ion (Zn). +25 total
0.874 Hit 25.6% 4.53e-07
811 KP13_04347 putative lipoprotein AlphaFold + ColabFold – – 0.874 No Hit 0.0% —
812 KP13_02884 Inner membrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.874 No Hit 0.0% —
813 KP13_01556 YeaR domain-containing protein AlphaFold + ColabFold – – 0.874 No Hit 0.0% —
814 KP13_01393 Plasmid stable inheritance protein pemI AlphaFold + ColabFold –
GO:0097351Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.874 No Hit 0.0% —
815 KP13_04423 putative oxidoreductase AlphaFold + ColabFold – – 0.873 No Hit 0.0% —
816 KP13_03139 Protein AsmA asmA AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0090313Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
0.873 No Hit 0.0% —
817 KP13_02736 alanine racemase domain-containing protein AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
0.873 Hit 66.7% 9.32e-06
818 KP13_00910 hypothetical protein AlphaFold + ColabFold – – 0.873 No Hit 0.0% —
819 KP13_00835 D-xylose-proton symporter xylE AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.873 Hit 34.7% 4.43e-22
820 KP13_00501 Outer membrane usher protein lpfC lpfC AlphaFold + ColabFold –
GO:0005515Binding to a protein. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473A porin that acts in the assembly of fimbria together with fimbrial chaperone. +25 total
0.873 No Hit 0.0% —
821 KP13_20988 hypothetical protein AlphaFold + ColabFold – – 0.872 No Hit 0.0% —
822 KP13_03964 hypothetical protein AlphaFold + ColabFold – – 0.872 No Hit 0.0% —
823 KP13_03023 putative amino acid/polyamine transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
0.872 Hit 32.6% 1.14e-06
824 KP13_02870 Serine/threonine transporter sstT sstT AlphaFold + ColabFold –
GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0032329The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
0.872 Hit 30.9% 1.62e-09
825 KP13_00411 Alpha-glucoside transport system permease protein aglF aglF AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.872 No Hit 0.0% —
Page of 208 · 5192 total proteins