Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
926 KP13_03225 Aerobic respiration control sensor protein arcB arcB AlphaFold + ColabFold
2.7.13.3
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). +811 total
0.869 No Hit 0.0% —
927 KP13_00141 hypothetical protein AlphaFold + ColabFold – – 0.869 No Hit 0.0% —
928 KP13_31619 Glutamate synthase [NADPH] large chain gltB AlphaFold + ColabFold
1.4.1.13
GO:0006537OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. GO:0016638Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +69 total
0.868 No Hit 0.0% —
929 KP13_04510 Respiratory nitrate reductase 2 delta chain narW AlphaFold + ColabFold –
GO:0051131The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. GO:0051082Binding to an unfolded protein. GO:0016530Binding to and delivering metal ions to a target protein. +14 total
0.868 No Hit 0.0% —
930 KP13_04293 hypothetical protein AlphaFold + ColabFold – – 0.868 No Hit 0.0% —
931 KP13_04133 TerY type protein AlphaFold + ColabFold – – 0.868 No Hit 0.0% —
932 KP13_04048 Phage DNA adenine methylase AlphaFold + ColabFold
2.1.1.-
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0006306OBSOLETE. The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. GO:0003676Binding to a nucleic acid. +36 total
0.868 No Hit 0.0% —
933 KP13_02994 Galactose-1-phosphate uridylyltransferase galT AlphaFold + ColabFold
2.7.7.12
GO:0006012The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. GO:0008270Binding to a zinc ion (Zn). GO:0033499The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose. +25 total
0.868 Hit 58.6% 4.52e-18
934 KP13_02827 G/U mismatch-specific DNA glycosylase mug AlphaFold + ColabFold
3.2.2.28
GO:0006285The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired. GO:0000700Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
0.868 Hit 47.5% 6.66e-07
935 KP13_05495 hypothetical protein AlphaFold + ColabFold – – 0.867 No Hit 0.0% —
936 KP13_04331 Inner membrane transport permease AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.867 No Hit 0.0% —
937 KP13_03636 hypothetical protein AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. +36 total
0.867 Hit 24.4% 1.32e-08
938 KP13_03544 Sulfate/thiosulfate import ATP-binding protein cysA cysA AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015419Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
0.867 Hit 55.0% 1.73e-06
939 KP13_03293 Deoxyribodipyrimidine photo-lyase phrB AlphaFold + ColabFold
4.1.99.3
GO:0003904Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +25 total
0.867 Hit 28.0% 7.57e-42
940 KP13_03274 Succinyl-CoA ligase [ADP-forming] subunit alpha sucD AlphaFold + ColabFold
6.2.1.5
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0009361A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +36 total
0.867 Hit 68.7% 5.63e-64
941 KP13_01033 tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC mnmC AlphaFold + ColabFold –
GO:0016645Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +69 total
0.867 No Hit 0.0% —
942 KP13_05424 Inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008653The chemical reactions and pathways involving lipopolysaccharides, a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide.
0.866 No Hit 0.0% —
943 KP13_04943 Multidrug resistance protein mdtG AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.866 Hit 31.4% 6.78e-10
944 KP13_04647 putative methylcobalamin:homocysteine methyltransferase metE AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0003871Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. +14 total
0.866 No Hit 0.0% —
945 KP13_04035 Gp17 phage protein AlphaFold + ColabFold –
GO:0046718The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell. GO:0098015Part of the virion that may be used to recognize, attach and inject the viral genome and accessory proteins into the host cell. GO:0030430The cytoplasm of a host cell. +14 total
0.866 No Hit 0.0% —
946 KP13_03768 Histidinol dehydrogenase hisD AlphaFold + ColabFold
1.1.1.23
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0046872Binding to a metal ion. +58 total
0.866 No Hit 0.0% —
947 KP13_03542 Sulfate transport system permease protein cysT cysU AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015419Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
0.866 No Hit 0.0% —
948 KP13_02117 branched-chain amino acid transport system permease AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.866 No Hit 0.0% —
949 KP13_02090 Anti-adapter protein iraP iraP AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009267Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
0.866 No Hit 0.0% —
950 KP13_01661 Inner membrane amino-acid ABC transporter permease protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +36 total
0.866 No Hit 0.0% —
Page of 234 · 5842 total proteins