Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
926 KP13_00390 Alanine racemase, biosynthetic alr AlphaFold DB model + ColabFold model
5.1.1.1
GO:0006522OBSOLETE. The chemical reactions and pathways involving alanine, 2-aminopropanoic acid. GO:0008784Catalysis of the reaction: L-alanine = D-alanine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +47 total
No map 0.907 0.551 No Hit 0.0% —
927 KP13_00160 Ferredoxin--NADP reductase fpr Experimental + ColabFold model
1.18.1.2 1.19.1.1
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0004324Catalysis of the reaction: 2 reduced [2Fe-2S]-[ferredoxin] + NADP+ + H+ = 2 oxidized [2Fe-2S]-[ferredoxin] + NADPH. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
No map 0.907 0.943 No Hit 0.0% —
928 KP13_03894 Putative dioxygenase subunit alpha AlphaFold DB model + ColabFold model
1.14.13.239
GO:0044237OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances. GO:0005506Binding to an iron (Fe) ion. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. +25 total
No map 0.906 0.979 No Hit 0.0% —
929 KP13_03840 NADP-dependent malic enzyme maeB AlphaFold DB model + ColabFold model
1.1.1.40
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0006108The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. GO:0046872Binding to a metal ion. +47 total
No map 0.906 0.811 Hit 26.1% 2.80e-13
930 KP13_01804 Phosphatidate cytidylyltransferase cdsA AlphaFold DB model + ColabFold model
2.7.7.41
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.906 0.737 Hit 30.6% 2.37e-10
931 KP13_01388 Streptomycin 3''-adenylyltransferase aadA AlphaFold DB model + ColabFold model
2.7.7.47
GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. GO:0070566Catalysis of the transfer of an adenylyl group to an acceptor. +25 total
No map 0.906 0.284 No Hit 0.0% —
932 KP13_01319 Inositol 2-dehydrogenase iolG AlphaFold DB model + ColabFold model
1.1.1.18
GO:0019310The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. GO:0050112Catalysis of the reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + H+ + NADH. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
No map 0.906 0.339 No Hit 0.0% —
933 KP13_00934 Polyphosphate kinase ppk AlphaFold DB model + ColabFold model
2.7.4.1
GO:0009358A protein complex that possesses polyphosphate kinase activity. GO:0008976Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +36 total
No map 0.906 0.509 No Hit 0.0% —
934 KP13_00660 Low-affinity gluconate transporter gntU AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015128Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose. GO:0035429The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose. +14 total
No map 0.906 0.888 No Hit 0.0% —
935 KP13_00564 5,10-methylenetetrahydrofolate reductase metF AlphaFold DB model + ColabFold model
1.5.1.54
GO:0006555The chemical reactions and pathways involving L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. +47 total
No map 0.906 0.142 Hit 38.2% 3.52e-24
936 KP13_32100 F-type conjugal transfer TraG-like protein AlphaFold DB model + ColabFold model – – No map 0.905 0.703 No Hit 0.0% —
937 KP13_32006 putative oxidoreductase AlphaFold DB model + ColabFold model –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.905 0.874 Hit 43.1% 5.23e-08
938 KP13_05521 putative NADH flavin oxidoreductase AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +14 total
No map 0.905 0.638 No Hit 0.0% —
939 KP13_04771 putative lysophospholipase AlphaFold DB model + ColabFold model – – No map 0.905 0.949 No Hit 0.0% —
940 KP13_04451 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.905 0.966 No Hit 0.0% —
941 KP13_04176 Asparaginyl-tRNA synthetase asnS AlphaFold DB model + ColabFold model
6.1.1.22
GO:0004816Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H+. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0003676Binding to a nucleic acid. +58 total
No map 0.905 0.973 Hit 57.1% 7.69e-11
942 KP13_03149 Multidrug resistance protein mdtB mdtB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.905 0.676 No Hit 0.0% —
943 KP13_01631 tRNA (mo5U34)-methyltransferase cmoB AlphaFold DB model + ColabFold model
2.5.1.-
GO:0002098The process in which a uridine at position 34 of a tRNA is post-transcriptionally modified. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon. GO:0016765Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +14 total
No map 0.905 0.744 No Hit 0.0% —
944 KP13_32135 beta-lactamase induction signal transducer AmpG ampG AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
No map 0.904 0.742 Hit 30.5% 2.02e-08
945 KP13_05457 Protein abrB abrB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0010468Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
No map 0.904 0.852 No Hit 0.0% —
946 KP13_04868 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.904 0.75 No Hit 0.0% —
947 KP13_03644 Arabinogalactan endo-1,4-beta-galactosidase ganB AlphaFold DB model + ColabFold model
3.2.1.89
GO:0015926Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. GO:0031218Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans. GO:0045490The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.
No map 0.904 0.461 No Hit 0.0% —
948 KP13_02881 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.904 No Hit 0.0% —
949 KP13_02831 putative sensor protein evgS AlphaFold DB model + ColabFold model –
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +25 total
No map 0.904 0.946 No Hit 0.0% —
950 KP13_02501 4-hydroxyphenylacetate 3-monooxygenase oxygenase component hpaB AlphaFold DB model + ColabFold model
1.14.14.9
GO:0016712Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate. +25 total
No map 0.904 0.876 No Hit 0.0% —
Page of 234 · 5842 total proteins