Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
951 KP13_00302 Cytoplasmic trehalase treF AlphaFold DB model + ColabFold model
3.2.1.28
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0071474Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. +36 total
No map 0.904 0.654 Hit 34.2% 6.20e-75
952 KP13_31936 aspartyl-tRNA synthetase aspS AlphaFold DB model + ColabFold model
6.1.1.12
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003676Binding to a nucleic acid. +69 total
No map 0.903 0.348 Hit 63.0% 1.23e-06
953 KP13_31520 Shikimate dehydrogenase AlphaFold DB model + ColabFold model –
GO:0004764Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. +47 total
No map 0.903 0.748 No Hit 0.0% —
954 KP13_03360 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0071453Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.
No map 0.903 0.668 No Hit 0.0% —
955 KP13_02964 RNase E specificity factor CsrD acsR AlphaFold DB model + ColabFold model – – No map 0.903 0.691 No Hit 0.0% —
956 KP13_02270 Lichenan permease IIC component licC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +14 total
No map 0.903 0.948 No Hit 0.0% —
957 KP13_00933 Exopolyphosphatase ppx Experimental + ColabFold model
3.6.1.11
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004309Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate. GO:0046872Binding to a metal ion. +14 total
No map 0.903 0.317 No Hit 0.0% —
958 KP13_00633 Protein rdoA rdoA AlphaFold DB model + ColabFold model
2.7.11.1
GO:0006468The process of introducing a phosphate group on to a protein. GO:0004674Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
No map 0.903 0.649 No Hit 0.0% —
959 KP13_03178 Xanthine/uracil/vitamin C permease family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0015205Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other. +47 total
No map 0.902 0.685 No Hit 0.0% —
960 KP13_01271 putative selenocysteine synthase AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004125Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate.
No map 0.902 0.29 No Hit 0.0% —
961 KP13_05605 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase waaU AlphaFold DB model + ColabFold model –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008713Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+. +14 total
No map 0.901 0.541 No Hit 0.0% —
962 KP13_05535 putative D-allulose-6-phosphate 3-epimerase AlphaFold DB model + ColabFold model
5.1.3.-
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0034700Catalysis of the reaction: D-allulose 6-phosphate = keto-D-fructose 6-phosphate. GO:0046872Binding to a metal ion. +25 total
No map 0.901 0.376 Hit 37.1% 5.09e-15
963 KP13_04896 Transcription-repair-coupling factor mfd AlphaFold DB model + ColabFold model
3.6.4.-
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. GO:0003684Binding to damaged DNA. +69 total
No map 0.901 0.894 No Hit 0.0% —
964 KP13_02739 Nucleoside-triphosphatase rdgB rdgB AlphaFold DB model + ColabFold model
3.6.1.66
GO:0009143The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. GO:0017111Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate. GO:0047429Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. +811 total
No map 0.901 0.6 Hit 31.6% 2.82e-13
965 KP13_00568 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
No map 0.901 0.892 No Hit 0.0% —
966 KP13_32378 transketolase 2 tkt2 AlphaFold DB model + ColabFold model
2.2.1.1
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004802Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.900 0.807 Hit 35.9% 1.23e-16
967 KP13_11777 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009306The controlled release of proteins from a cell. GO:0097347A heterooligomeric protein complex that spans the bacterial periplasm and enables the secretion of adhesin proteins in Gram-negative bacteria. In Citrobacter rodentium, Salmonella enterica and Escherichia coli, the TAM complex consists of an Omp85-family protein, TamA, in the outer membrane and TamB in the inner membrane.
No map 0.900 0.364 No Hit 0.0% —
968 KP13_05495 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.900 0.867 No Hit 0.0% —
969 KP13_05406 Inner membrane ABC transporter permease protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.900 0.746 No Hit 0.0% —
970 KP13_03351 putative bacterial antimicrobial peptide resistance protein PagP pagP AlphaFold DB model + ColabFold model
2.3.1.251
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0016409Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common.
No map 0.900 0.894 No Hit 0.0% —
971 KP13_02713 Glyoxalase/Bleomycin resistance protein/Dioxygenase domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.900 0.74 No Hit 0.0% —
972 KP13_02081 Protein aroM aroM AlphaFold DB model + ColabFold model – – No map 0.900 0.92 No Hit 0.0% —
973 KP13_02058 Acyl carrier protein phosphodiesterase acpH ColabFold model –
GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0008770Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein.
No map 0.900 0.349 No Hit 0.0% —
974 KP13_00428 Fimbrial biogenesis outer membrane usher protein AlphaFold DB model + ColabFold model –
GO:0005515Binding to a protein. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473A porin that acts in the assembly of fimbria together with fimbrial chaperone. +25 total
No map 0.900 0.779 No Hit 0.0% —
975 KP13_00223 PTS system mannitol-specific EIICBA component mtlA AlphaFold DB model + ColabFold model
2.7.1.197
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +47 total
No map 0.900 0.866 No Hit 0.0% —
Page of 234 · 5842 total proteins