Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4851 PA1670 serine/threonine phosphoprotein phosphatase Stp1 PA1670, stp1 AlphaFold –
GO:0004722Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. GO:0033103The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence. GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. +14 total
0.429 No Hit N/A —
4852 PA0760 hypothetical protein sdhE, PA0760 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0034552The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II. GO:0006105The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle.
0.429 No Hit N/A —
4853 PA0757 two-component sensor PA0757 AlphaFold
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +47 total
0.429 No Hit N/A —
4854 PA5351 rubredoxin alkG1, rubA1, PA5351 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0005506Binding to an iron (Fe) ion. +25 total
0.428 No Hit N/A —
4855 PA5081 hypothetical protein PA5081 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.428 No Hit N/A —
4856 PA1196 transcriptional regulator PA1196 AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. +710 total
0.428 No Hit N/A —
4857 PA3763 phosphoribosylformylglycinamidine synthase purL, PA3763 AlphaFold
6.3.5.3
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. +36 total
0.427 Hit 51.2% 5.33e-08
4858 PA0514 heme d1 biosynthesis protein NirL nirL, PA0514 AlphaFold
4.1.1.111
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0006783The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. +14 total
0.427 No Hit N/A —
4859 PA4917 hypothetical protein PA4917 AlphaFold
2.7.7.18
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004515Catalysis of the reaction: nicotinate beta-D-ribonucleotide + ATP + H+ = deamido-NAD+ + diphosphate. GO:0009435The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3. +36 total
0.426 No Hit N/A —
4860 PA4271 50S ribosomal protein L7/L12 rplL, PA4271 AlphaFold –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0003729Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +25 total
0.426 No Hit N/A —
4861 PA2930 transcriptional regulator PA2930 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template. +14 total
0.425 No Hit N/A —
4862 PA2232 biofilm formation protein PslB PA2232, pslB AlphaFold
2.7.7.13 5.3.1.8
GO:0005525Binding to GTP, guanosine triphosphate. GO:0050089Catalysis of the reaction: D-mannose = D-fructose. GO:0004475Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose. +811 total
0.425 No Hit N/A —
4863 PA3961 ATP-dependent helicase PA3961 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. GO:0017111Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate. +25 total
0.424 Hit 41.6% 3.72e-30
4864 PA3531 bacterioferritin bfrB, PA3531 Experimental + AlphaFold
1.16.3.1
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0070288A protein complex that binds iron and acts as a major iron storage system. There are three major subclasses of ferritins: the classical ferritins (Ftn), the heme-containing bacterioferritins (Bfr) and the DNA-binding proteins from starved cells (Dps). Ftn and Bfr are made of 24 subunits, whereas Dps are smaller with 12 subunits. Ftn is found in most kindoms, while Bfr and Dps are restricted to prokaryotes. GO:0008199Binding to a ferric iron ion, Fe(III). +69 total
0.424 No Hit N/A —
4865 PA2686 two-component response regulator PfeR PA2686, pfeR AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +47 total
0.423 No Hit N/A —
4866 PA5163 glucose-1-phosphate thymidylyltransferase PA5163, rmlA Experimental + AlphaFold
2.7.7.24
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008879Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose. GO:0046872Binding to a metal ion. +69 total
0.422 Hit 39.3% 9.03e-08
4867 PA3896 2-hydroxyacid dehydrogenase PA3896 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0030267Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+. GO:0016618Catalysis of the reaction: (R)-glycerate + NAD(P)+ = 3-hydroxypyruvate + NAD(P)H + H+. +25 total
0.422 Hit 44.0% 7.61e-55
4868 PA3118 3-isopropylmalate dehydrogenase leuB, PA3118 AlphaFold
1.1.1.85
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003862Catalysis of the reaction: (2R,3S)-3-isopropylmalate + NAD+ = 4-methyl-2-oxopentanoate + CO2 + NADH. GO:0000287Binding to a magnesium (Mg) ion. +36 total
0.422 Hit 38.4% 2.47e-06
4869 PA2735 restriction-modification system protein PA2735 AlphaFold
2.1.1.72
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0008170Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. GO:0009007Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine. +58 total
0.422 No Hit N/A —
4870 PA0371 hypothetical protein PA0371 AlphaFold –
GO:0046872Binding to a metal ion.
0.422 No Hit N/A —
4871 PA2458 hypothetical protein PA2458 AlphaFold – – 0.421 No Hit N/A —
4872 PA0662 N-acetyl-gamma-glutamyl-phosphate reductase PA0662, argC AlphaFold
1.2.1.38
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003942Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. +58 total
0.421 No Hit N/A —
4873 PA4398 two-component sensor PA4398 AlphaFold
2.7.13.3
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. +47 total
0.42 No Hit N/A —
4874 PA3806 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN PA3806, rlmN AlphaFold
2.1.1.192
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion. +1013 total
0.42 No Hit N/A —
4875 PA3582 glycerol kinase glpK2, glpK1, PA3582, glpK AlphaFold
2.7.1.30
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004370Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H+. +69 total
0.42 Hit 50.0% 5.47e-08
Page of 223 · 5572 total proteins