Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

Search, filter, and prioritize proteins.

Export view
5572 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4876 PA0796 2-methylisocitrate lyase prpB, PA0796 Experimental + AlphaFold
4.1.3.30
GO:0000287Binding to a magnesium (Mg) ion. GO:0046421Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate. GO:0019629OBSOLETE. The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle. +14 total
0.42 No Hit N/A —
4877 PA3799 GTPase Der der, PA3799, engA AlphaFold –
GO:0005525Binding to GTP, guanosine triphosphate. GO:0043022Binding to a ribosome. GO:0042254A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
0.419 Hit 28.4% 1.14e-08
4878 PA2359 transcriptional regulator PA2359 AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. +58 total
0.419 No Hit N/A —
4879 PA2215 hypothetical protein PA2215 AlphaFold
4.2.1.90
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0050032Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.419 Hit 29.1% 3.69e-21
4880 PA1357 hypothetical protein PA1357 AlphaFold –
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. GO:0106074Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation.
0.419 No Hit N/A —
4881 PA1175 nitrate reductase biosynthesis protein NapD PA1175, napD AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005048Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. GO:0051224Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.419 No Hit N/A —
4882 PA5339 hypothetical protein PA5339 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).
0.418 Hit 42.4% 1.04e-31
4883 PA3810 chaperone protein HscA hscA, PA3810 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +710 total
0.417 Hit 45.1% 6.98e-37
4884 PA2157 hypothetical protein PA2157 AlphaFold – – 0.417 No Hit N/A —
4885 PA3701 peptide chain release factor 1 PA3701, prfB AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016149A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. GO:0006415The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). +14 total
0.416 Hit 51.6% 4.94e-34
4886 PA3427 short-chain dehydrogenase PA3427 AlphaFold –
GO:0003857Catalysis of the reaction: a (3S)-3-hydroxyacyl-CoA + NAD+ = a 3-oxoacyl-CoA + NADH + H+. GO:0004300Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O. GO:0006635A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). +14 total
0.416 Hit 67.6% 8.75e-08
4887 PA2672 type II secretion system protein PA2672 AlphaFold – – 0.415 No Hit N/A —
4888 PA1440 hypothetical protein PA1440 AlphaFold – – 0.415 No Hit N/A —
4889 PA0682 HxcX atypical pseudopilin PA0682 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009306The controlled release of proteins from a cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.415 No Hit N/A —
4890 PA1287 glutathione peroxidase PA1287 AlphaFold –
GO:0004601Catalysis of the reaction: a reduced substrate + ROOH = an oxidized substrate + ROH + H2O. GO:0034599Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. GO:0006979Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. +14 total
0.414 Hit 43.1% 1.24e-06
4891 PA5400 electron transfer flavoprotein subunit alpha ColabFold –
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
0.413 Hit 48.7% 3.04e-12
4892 PA4105 hypothetical protein PA4105 AlphaFold – – 0.413 No Hit N/A —
4893 PA3803 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) gcpE ColabFold –
GO:0005506Binding to an iron (Fe) ion. GO:0016114The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. GO:0008299The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. +25 total
0.413 No Hit N/A —
4894 PA4711 hypothetical protein PA4711 AlphaFold –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion.
0.412 No Hit N/A —
4895 PA4522 N-acetyl-anhydromuranmyl-L-alanine amidase ampD, PA4522 AlphaFold
3.5.1.28
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009276The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. GO:0046872Binding to a metal ion. +47 total
0.411 No Hit N/A —
4896 PA3146 NAD-dependent epimerase/dehydratase PA3146, wbpK AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004029Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. +14 total
0.411 Hit 27.2% 2.91e-10
4897 PA2663 psl and pyoverdine operon regulator PpyR ppyR, PA2663 AlphaFold – – 0.411 No Hit N/A —
4898 PA1250 alkaline proteinase inhibitor AprI aprI, PA1250, inh Experimental + AlphaFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0008191Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. GO:0004866Binds to and stops, prevents or reduces the activity of an endopeptidase. +14 total
0.411 No Hit N/A —
4899 PA5060 polyhydroxyalkanoate synthesis protein PhaF PA5060, phaF AlphaFold – – 0.41 No Hit N/A —
4900 PA4951 oligoribonuclease orn, PA4951 Experimental + AlphaFold
3.1.15.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000175Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. GO:0003676Binding to a nucleic acid. +14 total
0.41 Hit 65.8% 4.77e-12
Page of 223 · 5572 total proteins