Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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701 / 5572 proteins Structure: Experimental

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Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
676 PA0300 putrescine ABC transporter substrate-binding protein SpuD PA0300, spuD Experimental + AlphaFold DB model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0019810Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. GO:0019809Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. +47 total
No map 0.261 No Hit N/A —
677 PA2260 hypothetical protein kguE, PA2260 Experimental + AlphaFold DB model – – No map 0.256 No Hit N/A —
678 PA1165 4'-phosphopantetheinyl transferase PA1165, pcpS Experimental + AlphaFold DB model –
GO:0009366A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway. GO:0008897Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. GO:0000287Binding to a magnesium (Mg) ion. +47 total
No map 0.256 No Hit N/A —
679 PA1244 hypothetical protein PA1244 Experimental + AlphaFold DB model – – No map 0.253 No Hit N/A —
680 PA3338 hypothetical protein PA3338 Experimental + AlphaFold DB model – – No map 0.252 No Hit N/A —
681 PA3485 hypothetical protein tsi3, PA3485 Experimental + AlphaFold DB model –
GO:0046872Binding to a metal ion.
No map 0.246 No Hit N/A —
682 PA4232 single-stranded DNA-binding protein PA4232, ssb Experimental + AlphaFold DB model –
GO:0009295The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. GO:0008047A molecular function regulator that increases a catalytic activity. GO:0003697Binding to single-stranded DNA. +36 total
No map 0.245 Hit 39.3% 2.70e-14
683 PA2591 transcriptional regulator PA2591 Experimental + AlphaFold DB model –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0001217A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. +47 total
No map 0.245 No Hit N/A —
684 PA1611 sensor/response regulator hybrid protein PA1611 Experimental + AlphaFold DB model
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009927Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator. +710 total
No map 0.244 No Hit N/A —
685 PA3805 type 4 fimbrial biogenesis protein PilF PA3805, pilF Experimental + AlphaFold DB model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0030911Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices. GO:0009297The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. +47 total
No map 0.242 Hit 28.8% 2.00e-06
686 PA4303 hypothetical protein tadZ, PA4303 Experimental + AlphaFold DB model –
GO:0009898The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
No map 0.238 No Hit N/A —
687 PA0330 ribose-5-phosphate isomerase A rpiA, PA0330 Experimental + AlphaFold DB model
5.3.1.6
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004751Catalysis of the reaction: aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate. GO:0006014The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. +14 total
No map 0.238 Hit 36.6% 1.50e-26
688 PA3115 motility protein FimV fimV, PA3115 Experimental + AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0044096A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers. +25 total
No map 0.228 No Hit N/A —
689 PA4397 2-dehydropantoate 2-reductase panE, PA4397 Experimental + AlphaFold DB model
1.1.1.169
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008677Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + H+ + NADPH. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. +25 total
No map 0.222 No Hit N/A —
690 PA1204 NAD(P)H-dependent FMN reductase PA1204 Experimental + AlphaFold DB model
1.-.-.-
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0052873Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+. +58 total
No map 0.219 No Hit N/A —
691 PA0263 secreted protein Hcp PA5267, hcpC, hcpB, hcpA Experimental + AlphaFold DB model – – No map 0.217 No Hit N/A —
692 PA0075 serine/threonine phosphatase PA0075, pppA Experimental + AlphaFold DB model –
GO:0046872Binding to a metal ion. GO:0004722Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. GO:0050709Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. +25 total
No map 0.212 No Hit N/A —
693 PA3818 type III secretion system regulator SuhB suhB, PA3818 Experimental + AlphaFold DB model
3.1.3.25
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008934Catalysis of the reaction: 1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. GO:0046872Binding to a metal ion. +69 total
No map 0.203 Hit 47.1% 2.43e-14
694 PA2072 hypothetical protein PA2072 Experimental + AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
No map 0.201 No Hit N/A —
695 PA0431 hypothetical protein PA0431 Experimental + AlphaFold DB model –
GO:0008893Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H+. GO:0046872Binding to a metal ion.
No map No pocket Hit 32.6% 1.73e-07
696 PA1431 regulatory protein RsaL PA1431, rsaL Experimental + AlphaFold DB model –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0001217A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. +811 total
No map No pocket No Hit N/A —
697 PA3229 hypothetical protein PA3229 Experimental + AlphaFold DB model – – No map No pocket No Hit N/A —
698 PA3530 hypothetical protein PA3530, bfd Experimental + AlphaFold DB model –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion.
No map No pocket No Hit N/A —
699 PA3664 hypothetical protein PA3664 Experimental + AlphaFold DB model – – No map No pocket No Hit N/A —
700 PA3988 hypothetical protein PA3988, lptE Experimental + AlphaFold DB model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:1990351A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. GO:0001530Binding to a lipopolysaccharide. +36 total
No map No pocket No Hit N/A —
Page of 29 · 701 total proteins