Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1051 PA4026 acetyltransferase PA4026 Experimental + AlphaFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.879 No Hit N/A —
1052 PA3356 hypothetical protein PA3356 AlphaFold –
GO:0004356Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate. GO:0006542OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. GO:0006598The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups. +25 total
0.879 Hit 25.2% 1.17e-22
1053 PA3302 hypothetical protein PA3302 AlphaFold –
GO:0005835A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. GO:0019171Catalysis of the reaction: a (3R)-hydroxyacyl-[acyl-carrier-protein] = a (2E)-enoyl-[acyl-carrier-protein] + H2O. GO:0004312Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. +14 total
0.879 Hit 32.6% 1.23e-22
1054 PA2567 hypothetical protein PA2567 Experimental + AlphaFold
3.1.4.52
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+. GO:1900190Any process that modulates the frequency, rate or extent of single-species biofilm formation. +14 total
0.879 No Hit N/A —
1055 PA2477 thiol:disulfide interchange protein PA2477 AlphaFold –
GO:0030313An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. GO:0015036Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
0.879 No Hit N/A —
1056 PA2442 glycine cleavage system protein T2 PA2442, gcvT2 AlphaFold
2.1.2.10
GO:0005960A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T. GO:0004047Catalysis of the reaction: N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4+. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +25 total
0.879 Hit 50.6% 3.31e-43
1057 PA2315 hypothetical protein PA2315 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.879 Hit 36.8% 8.69e-07
1058 PA2304 protein AmbC ambC, PA2304 AlphaFold –
GO:0016706Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. GO:0017000The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.879 No Hit N/A —
1059 PA1480 cytochrome c-type biogenesis protein CcmF ccmF, PA1480 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004096Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +912 total
0.879 No Hit N/A —
1060 PA0786 transporter PA0786 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.879 No Hit N/A —
1061 PA0702 hypothetical protein PA0702 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005506Binding to an iron (Fe) ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
0.879 Hit 26.9% 5.88e-06
1062 PA0672 heme oxygenase hemO ColabFold –
GO:0004392Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase]. GO:0006788The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme.
0.879 No Hit N/A —
1063 PA0182 3-ketoacyl-ACP reductase PA0182 AlphaFold –
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
0.879 Hit 43.6% 6.96e-07
1064 PA0131 beta-alanine degradation protein BauB bauB, PA0131 AlphaFold –
GO:0019483The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.
0.879 No Hit N/A —
1065 PA5159 multidrug resistance protein PA5159 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015125Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. +47 total
0.878 No Hit N/A —
1066 PA5085 transcriptional regulator PA5085 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. +25 total
0.878 No Hit N/A —
1067 PA4991 hypothetical protein PA4991 Experimental + AlphaFold
1.-.-.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.878 No Hit N/A —
1068 PA4372 hypothetical protein PA4372 AlphaFold –
GO:0030313An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.
0.878 No Hit N/A —
1069 PA4136 major facilitator superfamily transporter PA4136 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015385Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +47 total
0.878 Hit 36.9% 1.45e-06
1070 PA3851 hypothetical protein PA3851 AlphaFold –
GO:0012505A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005381Enables the transfer of iron (Fe) ions from one side of a membrane to the other. +25 total
0.878 No Hit N/A —
1071 PA3708 chemotaxis transducer PA3708, wspA AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004888Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). +25 total
0.878 No Hit N/A —
1072 PA3522 resistance-nodulation-cell division (RND) efflux transporter PA3522 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +58 total
0.878 No Hit N/A —
1073 PA3243 septum formation inhibitor minC, PA3243 AlphaFold –
GO:0060187Either of two different areas at opposite ends of an axis of a cell. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004857A molecular function regulator that reduces a catalytic activity. +69 total
0.878 No Hit N/A —
1074 PA1507 transporter PA1507 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042907Enables the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids. GO:0042906The directed movement of xanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids. +47 total
0.878 Hit 31.2% 3.09e-15
1075 PA1448 flagellar biosynthesis protein FliR fliR, PA1448 AlphaFold –
GO:0009425One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0044780The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility. +25 total
0.878 No Hit N/A —
Page of 223 · 5572 total proteins