Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1076 PA1418 sodium:solute symport protein PA1418 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
0.878 Hit 27.2% 1.44e-10
1077 PA1374 hypothetical protein PA1374 Experimental + AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.878 No Hit N/A —
1078 PA1353 hypothetical protein PA1353 Experimental + AlphaFold – – 0.878 No Hit N/A —
1079 PA1295 hypothetical protein PA1295 AlphaFold – – 0.878 No Hit N/A —
1080 PA0998 hypothetical protein PA0998, pqsC Experimental + AlphaFold
2.3.1.230
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. +25 total
0.878 No Hit N/A —
1081 PA0997 hypothetical protein pqsB, PA0997 Experimental + AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0044550The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.
0.878 No Hit N/A —
1082 PA0526 hypothetical protein PA0526 AlphaFold – – 0.878 No Hit N/A —
1083 PA0093 hypothetical protein tse6, PA0093 Experimental + AlphaFold
3.2.2.5
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0003953Catalysis of the reaction: NAD+ + H2O = ADP-D-ribose + nicotinamide + H+. GO:0050135Catalysis of the reaction: NADP+ + H2O = ADP-D-ribose 2'-phosphate + nicotinamide + H+. +25 total
0.878 No Hit N/A —
1084 PA0092 hypothetical protein tsi6, PA0092 Experimental + AlphaFold –
GO:0097351Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. GO:0033103The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
0.878 No Hit N/A —
1085 PA5246 hypothetical protein PA5246 AlphaFold
3.1.2.20
GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
0.877 No Hit N/A —
1086 PA3398 transcriptional regulator PA3398 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.877 No Hit N/A —
1087 PA2835 major facilitator superfamily transporter PA2835 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.877 No Hit N/A —
1088 PA0740 SDS hydrolase SdsA1 PA0740, sdsA1 Experimental + AlphaFold
3.1.6.21
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0042802Binding to an identical protein or proteins. GO:0018741Catalysis of the reaction: a primary linear alkyl sulfate ester + H2O = a primary alcohol + H+ + sulfate. +36 total
0.877 No Hit N/A —
1089 PA0631 hypothetical protein PA0631 AlphaFold – – 0.877 No Hit N/A —
1090 PA5297 pyruvate dehydrogenase poxB, PA5297 AlphaFold –
GO:0000287Binding to a magnesium (Mg) ion. GO:0052737Catalysis of the reaction: a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2. GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. +25 total
0.876 Hit 33.0% 2.32e-07
1091 PA4066 hypothetical protein PA4066 Experimental + AlphaFold – – 0.876 No Hit N/A —
1092 PA3844 hypothetical protein PA3844 AlphaFold –
GO:0004364Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+. GO:0016034Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate. GO:0006749The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. +14 total
0.876 Hit 29.3% 8.53e-07
1093 PA3761 N-acetyl-D-glucosamine phosphotransferase system transporter PA3761 AlphaFold –
GO:0019866The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +69 total
0.876 No Hit N/A —
1094 PA3673 glycerol-3-phosphate acyltransferase PA3673, plsB AlphaFold
2.3.1.15
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004366Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA. GO:0016024The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. +58 total
0.876 Hit 40.0% 4.54e-35
1095 PA3665 hypothetical protein PA3665 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015171Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
0.876 No Hit N/A —
1096 PA2933 major facilitator superfamily transporter PA2933 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.876 No Hit N/A —
1097 PA1466 hypothetical protein PA1466 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004364Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+.
0.876 No Hit N/A —
1098 PA0850 hypothetical protein PA0850 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.876 No Hit N/A —
1099 PA5474 metalloprotease PA5474 AlphaFold –
GO:0046872Binding to a metal ion. GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
0.875 Hit 33.3% 5.74e-06
1100 PA5439 glucose-6-phosphate 1-dehydrogenase zwf, PA5439 AlphaFold
1.1.1.49
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004345Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. +36 total
0.875 Hit 39.2% 2.99e-86
Page of 223 · 5572 total proteins