Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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701 / 5572 proteins Structure: Experimental

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Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
151 PA2950 reductase PA2950, fabV Experimental + AlphaFold DB model
1.3.1.9 1.3.1.44
GO:0004318Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NAD+ = a (2E)-enoyl-[ACP] + H+ + NADH. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0050343Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH. +25 total
No map 0.849 No Hit N/A —
152 PA0223 dihydrodipicolinate synthetase PA0223 Experimental + AlphaFold DB model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008840Catalysis of the reaction: L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+. GO:0046872Binding to a metal ion. +14 total
No map 0.849 Hit 26.0% 3.07e-16
153 PA1966 hypothetical protein PA1966 Experimental + AlphaFold DB model –
GO:0008704Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate. GO:0019439OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
No map 0.847 No Hit N/A —
154 PA0620 bacteriophage protein PA0620, HR2 Experimental + AlphaFold DB model –
GO:0046872Binding to a metal ion.
No map 0.846 No Hit N/A —
155 PA5043 type 4 fimbrial biogenesis protein PilN pilN, PA5043 Experimental + AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0044096A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers. GO:0043683The assembly from its constituent parts of a type IV pilus. +14 total
No map 0.845 No Hit N/A —
156 PA3335 hypothetical protein PA3335 Experimental + AlphaFold DB model – – No map 0.844 No Hit N/A —
157 PA1079 flagellar basal body rod modification protein flgD, PA1079 Experimental + AlphaFold DB model –
GO:0044781A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility.
No map 0.844 No Hit N/A —
158 PA4794 hypothetical protein PA4794 Experimental + AlphaFold DB model –
GO:0046872Binding to a metal ion. GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.843 No Hit N/A —
159 PA2412 hypothetical protein PA2412 Experimental + AlphaFold DB model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0002049The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine. GO:0019290The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.
No map 0.843 No Hit N/A —
160 PA1492 hypothetical protein PA1492 Experimental + AlphaFold DB model – – No map 0.843 No Hit N/A —
161 PA1648 oxidoreductase PA1648 Experimental + AlphaFold DB model –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0016628Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.842 Hit 41.2% 1.11e-50
162 PA0477 transcriptional regulator PA0477 Experimental + AlphaFold DB model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.842 No Hit N/A —
163 PA4051 thiamine monophosphate kinase thiL, PA4051 Experimental + AlphaFold DB model
2.7.4.16
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000287Binding to a magnesium (Mg) ion. GO:0009030Catalysis of the reaction: ATP + thiamine phosphate = ADP + H+ + thiamine diphosphate. +25 total
No map 0.841 No Hit N/A —
164 PA3217 protein CyaB PA3217, cyaB Experimental + AlphaFold DB model –
GO:0004016Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. GO:0006171The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). GO:0035556The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. +14 total
No map 0.841 Hit 29.9% 8.10e-12
165 PA1806 NADH-dependent enoyl-ACP reductase fabI, PA1806 Experimental + AlphaFold DB model
1.3.1.9
GO:0004318Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NAD+ = a (2E)-enoyl-[ACP] + H+ + NADH. GO:0042802Binding to an identical protein or proteins. GO:0030497The elongation of a fatty acid chain by the sequential addition of two-carbon units. +14 total
No map 0.84 Hit 34.0% 1.15e-07
166 PA3263 recombination associated protein RdgC rdgC, PA3263 Experimental + AlphaFold DB model –
GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003690Binding to double-stranded DNA. +25 total
No map 0.839 No Hit N/A —
167 PA3067 transcriptional regulator PA3067 Experimental + AlphaFold DB model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.838 No Hit N/A —
168 PA4425 phosphoheptose isomerase PA4425, gmhA Experimental + AlphaFold DB model
5.3.1.28
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990102A protein-DNA complex containing a tetramer of DiaA attached to multiple DnaA molecule bound to oriC DNA. Regulates timely initiation of chromosomal replication during the cell cycle by stimulating assembly of DnaA-oriC complexes, conformational changes in ATP-DnaA initiation complexes, and unwinding of oriC duplex DNA. GO:0097367Binding to a carbohydrate derivative. +69 total
No map 0.837 No Hit N/A —
169 PA2654 chemotaxis transducer PA2654, tlpQ Experimental + AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. +14 total
No map 0.837 No Hit N/A —
170 PA0094 hypothetical protein eagT6, PA0094 Experimental + AlphaFold DB model – – No map 0.836 No Hit N/A —
171 PA4923 hypothetical protein PA4923 Experimental + AlphaFold DB model
3.2.2.n1 3.2.2.4
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008714Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine. GO:0102682Catalysis of the reaction: N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O = N(6)-dimethylallyladenine + D-ribose 5-phosphate. +36 total
No map 0.835 No Hit N/A —
172 PA1534 recombination protein RecR PA1534, recR Experimental + AlphaFold DB model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0008270Binding to a zinc ion (Zn). GO:0006302The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. +47 total
No map 0.835 No Hit N/A —
173 PA5349 rubredoxin reductase PA5349, alkT Experimental + AlphaFold DB model
1.18.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +36 total
No map 0.834 Hit 22.8% 6.22e-06
174 PA5083 hypothetical protein PA5083 Experimental + AlphaFold DB model – – No map 0.834 No Hit N/A —
175 PA4309 chemotactic transducer PctA pctA, PA4309 Experimental + AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016597Binding to an amino acid, organic acids containing one or more amino substituents. GO:0004888Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. +47 total
No map 0.834 Hit 25.7% 9.48e-09
Page of 29 · 701 total proteins