Proteins

Genome: NZ_AP023069.1

Description: Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome

Search, filter, and prioritize proteins.

Export view
44 proteins Structure: AlphaFold

Scoring formula None

Sorted by Druggability (descending)

Applied filters Structure: AlphaFold

Search query No active search

Rows per page 25

Rows
Active criteria 1
Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 HT085_RS00090 GAF domain-containing protein ytsP, msrC AlphaFold
1.8.4.14
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0033745Catalysis of the reaction: [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol.
No pocket No Hit — —
2 HT085_RS00175 1-deoxy-D-xylulose-5-phosphate synthase dxs AlphaFold
2.2.1.7
GO:0016114The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. GO:0008661Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H+ + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
No pocket Hit — —
3 HT085_RS00015 polyphosphate kinase 1 ppk, ppk1 AlphaFold
2.7.4.1
GO:0008976Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). GO:0009358A protein complex that possesses polyphosphate kinase activity. GO:0006799The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid. +25 total
No pocket No Hit — —
4 HT085_RS00005 chromosomal replication initiator protein DnaA dnaA AlphaFold –
GO:0006270The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003688Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. +69 total
No pocket No Hit — —
5 HT085_RS00370 signal peptidase II lspA AlphaFold
3.4.23.36
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0004190Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No pocket No Hit — —
6 HT085_RS00020 hypothetical protein AlphaFold – – No pocket No Hit — —
7 HT085_RS00130 amino-acid N-acetyltransferase argA AlphaFold
2.3.1.1
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006526The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. +14 total
No pocket No Hit — —
8 HT085_RS00135 MJ0042-type zinc finger domain-containing protein AlphaFold – – No pocket No Hit — —
9 HT085_RS00140 orotate phosphoribosyltransferase pyrE AlphaFold
2.4.2.10
GO:0004588Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000287Binding to a magnesium (Mg) ion. +36 total
No pocket Hit — —
10 HT085_RS00215 oligoribonuclease orn AlphaFold
3.1.-.-
GO:0003676Binding to a nucleic acid. GO:0000175Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No pocket Hit — —
11 HT085_RS00145 uracil-DNA glycosylase family protein AlphaFold – – No pocket No Hit — —
12 HT085_RS00170 tyrosine recombinase XerC xerC AlphaFold –
GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0007059The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +36 total
No pocket No Hit — —
13 HT085_RS00200 glutamate-1-semialdehyde 2,1-aminomutase hemL AlphaFold
5.4.3.8
GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0042286Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate. +25 total
No pocket Hit — —
14 HT085_RS00335 tyrosine--tRNA ligase tyrS AlphaFold
6.1.1.1
GO:0004831Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+. GO:0006437The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0003723Binding to an RNA molecule or a portion thereof. +36 total
No pocket Hit — —
15 HT085_RS00325 hypothetical protein AlphaFold – – No pocket No Hit — —
16 HT085_RS00155 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB tsaB, yeaZ AlphaFold –
GO:0002949The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No pocket No Hit — —
17 HT085_RS00230 acetyl-CoA carboxylase biotin carboxyl carrier protein accB AlphaFold –
GO:0003989Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. GO:0009317A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
No pocket Hit — —
18 HT085_RS00240 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA queA AlphaFold
2.4.99.17
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051075Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA. GO:0008616The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in position 34 of tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon.
No pocket No Hit — —
19 HT085_RS00320 redox-regulated ATPase YchF engD, ychF AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005525Binding to GTP, guanosine triphosphate. +36 total
No pocket Hit — —
20 HT085_RS00030 leucine--tRNA ligase leuS Experimental + AlphaFold
6.1.1.4
GO:0004823Catalysis of the reaction: leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H+ + Leu-tRNA(Leu). GO:0006429The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +25 total
No pocket Hit — —
21 HT085_RS00295 MarR family adhesin repressor NadR hpcR, ohrR, nadR, farR, marR1 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No pocket No Hit — —
22 HT085_RS00085 triose-phosphate isomerase tpiA AlphaFold
5.3.1.1
GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. GO:0004807Catalysis of the reaction: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
No pocket Hit — —
23 HT085_RS00110 cupin domain-containing protein AlphaFold – – No pocket No Hit — —
24 HT085_RS00115 siderophore ABC transporter substrate-binding protein AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:1901678The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No pocket No Hit — —
25 HT085_RS00385 HAD-IA family hydrolase AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008967Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
No pocket No Hit — —
Page of 2 · 44 total proteins