Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5101 KP13_02051 Glyoxalase/bleomycin resistance domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.071 0.078 No Hit 0.0% —
5102 KP13_00488 Aspartate ammonia-lyase aspA AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006531The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. +25 total
No map 0.071 0.346 Hit 42.9% 2.13e-27
5103 KP13_00469 TerC family integral membrane protein terC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.071 0.518 No Hit 0.0% —
5104 KP13_05280 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.070 0.685 No Hit 0.0% —
5105 KP13_04848 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.070 0.425 No Hit 0.0% —
5106 KP13_03330 putative Filamentous hemagglutinin AlphaFold DB model + ColabFold model – – No map 0.070 0.294 No Hit 0.0% —
5107 KP13_02639 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.07 No Hit 0.0% —
5108 KP13_01708 Protein cyaY cyaY AlphaFold DB model + ColabFold model –
GO:0008199Binding to a ferric iron ion, Fe(III). GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map N/A 0.07 No Hit 0.0% —
5109 KP13_00957 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.070 0.838 No Hit 0.0% —
5110 KP13_00808 Sigma-E factor regulatory protein rseB rseB AlphaFold DB model + ColabFold model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0045152Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator. GO:0032885Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.
No map 0.070 0.707 No Hit 0.0% —
5111 KP13_00242 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
No map 0.070 0.435 No Hit 0.0% —
5112 KP13_31760 putative lipoprotein AlphaFold DB model + ColabFold model – – No map 0.069 0.333 No Hit 0.0% —
5113 KP13_12391 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.069 0.412 No Hit 0.0% —
5114 KP13_03349 Protein crcB crcB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0062054Enables the energy-independent facilitated diffusion of a fluoride ion through a transmembrane aqueous pore or channel. +25 total
No map 0.069 0.362 No Hit 0.0% —
5115 KP13_02066 antibiotic biosynthesis monooxygenase AlphaFold DB model + ColabFold model – – No map 0.069 0.721 No Hit 0.0% —
5116 KP13_04311 Glutamine transport system permease protein glnP glnP AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +36 total
No map 0.068 0.697 No Hit 0.0% —
5117 KP13_03846 Ethanolamine utilization protein eutM eutM AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map 0.068 0.767 No Hit 0.0% —
5118 KP13_03281 Succinate dehydrogenase cytochrome b556 subunit sdhC AlphaFold DB model + ColabFold model –
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. +69 total
No map 0.068 0.676 No Hit 0.0% —
5119 KP13_01576 Mannose permease IIC component manY AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.068 0.971 No Hit 0.0% —
5120 KP13_01498 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.068 No Hit 0.0% —
5121 KP13_01182 Malonate utilization transcriptional regulator mauR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0032993A macromolecular complex containing both protein and DNA molecules. +14 total
No map 0.068 0.79 No Hit 0.0% —
5122 KP13_31608 putative lipoprotein AlphaFold DB model + ColabFold model – – No map N/A 0.067 No Hit 0.0% —
5123 KP13_05168 hypothetical protein ColabFold model – – No map 0.067 0.693 No Hit 0.0% —
5124 KP13_05119 putative glyoxalase AlphaFold DB model + ColabFold model – – No map 0.067 0.928 No Hit 0.0% —
5125 KP13_04530 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0006276The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division. GO:0008657Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
No map 0.067 0.119 No Hit 0.0% —
Page of 234 · 5842 total proteins