Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5126 KP13_04344 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.067 0.31 No Hit 0.0% —
5127 KP13_04145 Tellurium resistance protein terA terA AlphaFold DB model + ColabFold model – – No map 0.067 0.604 No Hit 0.0% —
5128 KP13_03338 Ribosomal RNA large subunit methyltransferase H rlmH AlphaFold DB model + ColabFold model
2.1.1.177
GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.067 0.411 No Hit 0.0% —
5129 KP13_02556 N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA component chbA AlphaFold DB model + ColabFold model –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0046872Binding to a metal ion. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
No map N/A 0.067 No Hit 0.0% —
5130 KP13_04945 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.066 0.722 No Hit 0.0% —
5131 KP13_04159 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.066 0.77 No Hit 0.0% —
5132 KP13_03057 putative DotU-containing Type IV / VI secretion system protein AlphaFold DB model + ColabFold model – – No map 0.066 0.735 No Hit 0.0% —
5133 KP13_01177 Malonate decarboxylase subunit beta mdcD AlphaFold DB model + ColabFold model –
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0003989Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. +36 total
No map 0.066 0.771 Hit 28.6% 1.06e-07
5134 KP13_32375 phi assembly chaperone domain-containing protein ColabFold model –
GO:0061077OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +14 total
No map 0.065 0.606 No Hit 0.0% —
5135 KP13_31744 Formate dehydrogenase-O iron-sulfur subunit fdoH AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015944The chemical reactions and pathways by which formate is converted to CO2. GO:0045333The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). +69 total
No map 0.065 0.478 No Hit 0.0% —
5136 KP13_31639 LexA DNA binding domain-containing protein ColabFold model –
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
No map 0.065 0.711 No Hit 0.0% —
5137 KP13_06677 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.065 0.796 No Hit 0.0% —
5138 KP13_05241 putative D-methionine transport system permease protein metI AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.065 0.871 No Hit 0.0% —
5139 KP13_04286 Isoaspartyl peptidase iaaA AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.065 0.344 Hit 42.0% 1.96e-22
5140 KP13_03463 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.065 0.43 No Hit 0.0% —
5141 KP13_02573 Formate hydrogenlyase subunit 2 hycB AlphaFold DB model + ColabFold model –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion.
No map 0.065 0.285 No Hit 0.0% —
5142 KP13_02336 Protein cbiM cbiM AlphaFold DB model + ColabFold model –
GO:0000041The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006824The directed movement of cobalt (Co2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
No map 0.065 0.651 No Hit 0.0% —
5143 KP13_02316 Propanediol dehydratase medium subunit pduD AlphaFold DB model + ColabFold model – – No map 0.065 0.754 No Hit 0.0% —
5144 KP13_01587 Transcriptional regulator kdgR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.065 0.971 No Hit 0.0% —
5145 KP13_00787 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.065 No Hit 0.0% —
5146 KP13_00375 Maltose operon periplasmic protein malM AlphaFold DB model + ColabFold model –
GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.065 0.431 No Hit 0.0% —
5147 KP13_04865 high frequency lysogenization protein hflD hflD AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.064 0.561 No Hit 0.0% —
5148 KP13_04333 putative Inner membrane protein AlphaFold DB model + ColabFold model – – No map 0.064 0.988 No Hit 0.0% —
5149 KP13_04137 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.064 0.526 No Hit 0.0% —
5150 KP13_02188 hypothetical protein AlphaFold DB model + ColabFold model –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0097367Binding to a carbohydrate derivative. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +25 total
No map 0.064 0.233 No Hit 0.0% —
Page of 234 · 5842 total proteins