Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2601 PA3482 methionine--tRNA ligase PA3482, metG Experimental + AlphaFold
6.1.1.10
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. +69 total
0.751 Hit 51.4% 3.46e-07
2602 PA2726 radical activating enzyme PA2726 AlphaFold –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0046872Binding to a metal ion. +14 total
0.751 No Hit N/A —
2603 PA1870 hypothetical protein PA1870 AlphaFold – – 0.751 No Hit N/A —
2604 PA0812 hypothetical protein PA0812 AlphaFold –
GO:0043720Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate. GO:0046872Binding to a metal ion.
0.751 No Hit N/A —
2605 PA0660 hypothetical protein PA0660 AlphaFold –
GO:0018580Catalysis of the reaction: ethylnitronate + O2 = acetaldehyde + nitrite.
0.751 No Hit N/A —
2606 PA5554 ATP synthase subunit beta PA5554, atpD AlphaFold
7.1.2.2
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0045259A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +69 total
0.75 Hit 77.4% 5.35e-85
2607 PA5128 preprotein translocase subunit SecB secB, PA5128 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0070678Binding to a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing. GO:0051082Binding to an unfolded protein. +58 total
0.75 No Hit N/A —
2608 PA4952 ribosome-associated GTPase PA4952, rsgA Experimental + AlphaFold
3.6.1.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005525Binding to GTP, guanosine triphosphate. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. +36 total
0.75 No Hit N/A —
2609 PA1420 hypothetical protein PA1420 AlphaFold – – 0.75 No Hit N/A —
2610 PA1036 hypothetical protein PA1036 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.75 No Hit N/A —
2611 PA0496 hypothetical protein PA0496 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.75 No Hit N/A —
2612 PA0482 malate synthase G glcB, PA0482 Experimental + AlphaFold
2.3.3.9
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000287Binding to a magnesium (Mg) ion. GO:0004474Catalysis of the reaction: acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H+. +47 total
0.75 No Hit N/A —
2613 PA0123 transcriptional regulator PA0123 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template. +14 total
0.75 No Hit N/A —
2614 PA4927 hypothetical protein PA4927 AlphaFold – – 0.749 No Hit N/A —
2615 PA4140 hypothetical protein PA4140 AlphaFold –
GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0022904A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. +25 total
0.749 No Hit N/A —
2616 PA3533 hypothetical protein PA3533 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0015036Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. +25 total
0.749 Hit 40.2% 6.07e-25
2617 PA2855 hypothetical protein PA2855 AlphaFold – – 0.749 No Hit N/A —
2618 PA2770 isomerase PA2770 AlphaFold
5.1.-.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +14 total
0.749 Hit 40.3% 1.40e-55
2619 PA2738 integration host factor subunit alpha himA, PA2738, ihfA AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +710 total
0.749 No Hit N/A —
2620 PA2524 two-component sensor PA2524 Experimental + AlphaFold
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. +710 total
0.749 No Hit N/A —
2621 PA2365 hypothetical protein PA2365 AlphaFold – – 0.749 No Hit N/A —
2622 PA1324 hypothetical protein PA1324 Experimental + AlphaFold – – 0.749 No Hit N/A —
2623 PA0913 Mg transporter MgtE PA0913, mgtE AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0000287Binding to a magnesium (Mg) ion. GO:0015095Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. +47 total
0.749 No Hit N/A —
2624 PA0342 thymidylate synthase thyA, PA0342 AlphaFold
2.1.1.45
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004799Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. GO:0006231The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). +36 total
0.749 Hit 51.1% 8.31e-98
2625 PA5440 peptidase PA5440 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
0.748 No Hit N/A —
Page of 223 · 5572 total proteins