Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2576 PA2179 hypothetical protein PA2179 AlphaFold –
GO:0003676Binding to a nucleic acid. GO:0036009Catalysis of the reaction: L-glutaminyl-[protein] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine + H+. GO:0032259The process in which a methyl group is covalently attached to a molecule. +25 total
0.753 No Hit N/A —
2577 PA1836 transcriptional regulator PA1836 Experimental + AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.753 No Hit N/A —
2578 PA0855 hypothetical protein PA0855 AlphaFold – – 0.753 No Hit N/A —
2579 PA0607 ribulose-phosphate 3-epimerase PA0607, rpe Experimental + AlphaFold
5.1.3.1
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004750Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. GO:0046872Binding to a metal ion. +58 total
0.753 Hit 39.5% 2.14e-39
2580 PA0495 hypothetical protein PA0495 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.753 No Hit N/A —
2581 PA0179 two-component response regulator PA0179 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
0.753 No Hit N/A —
2582 PA5544 hypothetical protein PA5544 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
0.752 No Hit N/A —
2583 PA5124 two-component sensor NtrB PA5124, ntrB AlphaFold
2.7.13.3
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +58 total
0.752 No Hit N/A —
2584 PA3922 hypothetical protein PA3922 AlphaFold – – 0.752 No Hit N/A —
2585 PA3644 acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase lpxA, PA3644 AlphaFold
2.3.1.129
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008780Catalysis of the reaction: a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]. +47 total
0.752 No Hit N/A —
2586 PA3404 hypothetical protein PA3404 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:1990281A protein complex that is capable of efflux transmembrane transporter activity. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. +36 total
0.752 No Hit N/A —
2587 PA3292 hypothetical protein PA3292 AlphaFold – – 0.752 No Hit N/A —
2588 PA3185 hypothetical protein PA3185 AlphaFold
5.1.3.15
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0047938Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +25 total
0.752 No Hit N/A —
2589 PA2684 hypothetical protein PA2684, tse5 AlphaFold –
GO:0097351Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. GO:0033103The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
0.752 No Hit N/A —
2590 PA2088 hypothetical protein PA2088 AlphaFold –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
0.752 No Hit N/A —
2591 PA1900 phenazine biosynthesis protein PhzB PA1900, phzB2 Experimental + AlphaFold –
GO:0002047The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring. GO:0017000The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
0.752 No Hit N/A —
2592 PA1897 hypothetical protein PA1897 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005506Binding to an iron (Fe) ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
0.752 Hit 26.8% 5.83e-07
2593 PA0335 hypothetical protein PA0335 AlphaFold
3.1.3.15
GO:0004401Catalysis of the reaction: L-histidinol phosphate + H2O = L-histidinol + phosphate. GO:0046872Binding to a metal ion. GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
0.752 No Hit N/A —
2594 PA0210 malonate decarboxylase acyl carrier protein mdcC, PA0210 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000036Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis.
0.752 No Hit N/A —
2595 PA5550 GlmR transcriptional regulator glmR, PA5550 AlphaFold –
GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0098531A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. +58 total
0.751 No Hit N/A —
2596 PA5433 hypothetical protein PA5433 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990189Catalysis of the reaction: acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H+ + N-terminal Nalpha-acetyl-L-seryl-[protein]. GO:0008999Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H+ + N-terminal N(alpha)-acetyl-L-alanyl-[protein]. +14 total
0.751 No Hit N/A —
2597 PA4998 hypothetical protein PA4998 AlphaFold – – 0.751 No Hit N/A —
2598 PA4546 two-component sensor PilS pilS, PA4546 AlphaFold
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. +47 total
0.751 No Hit N/A —
2599 PA4230 isochorismate-pyruvate lyase pchB, PA4230 Experimental + AlphaFold
4.2.99.21 5.4.99.5
GO:0016835Catalysis of the breakage of a carbon-oxygen bond. GO:0004106Catalysis of the reaction: chorismate = prephenate. GO:0043904Catalysis of the reaction: isochorismate = salicylate + pyruvate. +36 total
0.751 No Hit N/A —
2600 PA4168 second ferric pyoverdine receptor FpvB fpvB, PA4168 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015344Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). GO:0038023Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. +47 total
0.751 No Hit N/A —
Page of 223 · 5572 total proteins