Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
451 PA0948 hypothetical protein PA0948 AlphaFold – – 0.928 No Hit N/A —
452 PA0763 sigma factor AlgU negative regulator MucA mucA, PA0763 Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016989The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity. GO:0042121The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). +14 total
0.928 No Hit N/A —
453 PA0376 RNA polymerase sigma factor RpoH rpoH, PA0376 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0016987Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. +47 total
0.928 No Hit N/A —
454 PA0205 ABC transporter permease PA0205 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015417Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in). GO:1903711The process in which spermidine is transported across a membrane. +25 total
0.928 No Hit N/A —
455 PA5251 hypothetical protein PA5251 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008381Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
0.927 No Hit N/A —
456 PA5204 N-acetylglutamate synthase PA5204, argA AlphaFold
2.3.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0042802Binding to an identical protein or proteins. GO:0004042Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H+. +36 total
0.927 No Hit N/A —
457 PA5160 drug efflux transporter pmrB, PA5160 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0015721The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
0.927 No Hit N/A —
458 PA4810 nitrate-inducible formate dehydrogenase subunit gamma fdnI, PA4810 AlphaFold –
GO:0009326An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. +811 total
0.927 No Hit N/A —
459 PA4559 lipoprotein signal peptidase ls, PA4559, lspA Experimental + AlphaFold
3.4.23.36
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004190Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. GO:0004175Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. +36 total
0.927 No Hit N/A —
460 PA4429 cytochrome C1 PA4429 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +14 total
0.927 No Hit N/A —
461 PA4074 transcriptional regulator PA4074 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.927 No Hit N/A —
462 PA2306 protein AmbA PA2306, ambA AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015171Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. GO:0033228The directed movement of cysteine from inside of a cell, across the plasma membrane and into the extracellular region. +25 total
0.927 No Hit N/A —
463 PA1775 hypothetical protein cmpX, PA1775 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008381Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
0.927 No Hit N/A —
464 PA1467 hypothetical protein PA1467 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.927 No Hit N/A —
465 PA1230 hypothetical protein PA1230 AlphaFold – – 0.927 No Hit N/A —
466 PA0936 lipopolysaccharide biosynthetic protein LpxO lpxO2, PA0936 AlphaFold –
GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. GO:0018193The alteration of an amino acid residue in a peptide.
0.927 Hit 30.6% 1.54e-06
467 PA0829 hydrolase PA0829 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.927 Hit 29.5% 5.98e-08
468 PA0443 transporter PA0443 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015205Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other. GO:0015851The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
0.927 No Hit N/A —
469 PA0414 methylesterase PA0414, chpB AlphaFold
3.1.1.61
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. GO:0008984Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol. +47 total
0.927 No Hit N/A —
470 PA0119 C4-dicarboxylate transporter DctA dctA1, PA0119 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015138Enables the transfer of fumarate from one side of a membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. GO:0015366Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in). +58 total
0.927 Hit 33.9% 8.45e-13
471 PA5426 5-(carboxyamino)imidazole ribonucleotide mutase PA5426, purE AlphaFold
5.4.99.18
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0034023Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate. GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
0.926 Hit 32.4% 2.39e-08
472 PA5134 carboxyl-terminal protease PA5134 Experimental + AlphaFold –
GO:0030313An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +1013 total
0.926 No Hit N/A —
473 PA4593 ABC transporter permease PA4593 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.926 No Hit N/A —
474 PA3986 hypothetical protein PA3986 AlphaFold – – 0.926 No Hit N/A —
475 PA3575 hypothetical protein PA3575 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +36 total
0.926 No Hit N/A —
Page of 223 · 5572 total proteins