Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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701 / 5572 proteins Structure: Experimental

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Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
76 PA4376 nicotinate phosphoribosyltransferase pncB2, PA4376 Experimental + AlphaFold DB model
6.3.4.21
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004516Catalysis of the reaction: nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate. GO:0034355The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide (NAD+) from vitamin B3 derivatives (including nicotinic acid (NA) and nicotinamide (NAM)), beta-nicotinamide D-ribonucleotide (NMN), nicotinamide riboside (NR) or nicotinate riboside (NAR), without de novo synthesis. +14 total
No map 0.902 No Hit N/A —
77 PA3984 apolipoprotein N-acyltransferase PA3984, cutE, lnt Experimental + AlphaFold DB model
2.3.1.269
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016410Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. GO:0042158The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. +25 total
No map 0.902 No Hit N/A —
78 PA1645 hypothetical protein PA1645 Experimental + AlphaFold DB model – – No map 0.902 No Hit N/A —
79 PA3020 lytic transglycosylase PA3020 Experimental + AlphaFold DB model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond.
No map 0.9 No Hit N/A —
80 PA1454 flagellar synthesis regulator FleN fleN, PA1454 Experimental + AlphaFold DB model –
GO:0009898The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
No map 0.9 Hit 31.0% 1.81e-08
81 PA0856 hypothetical protein PA0856 Experimental + AlphaFold DB model – – No map 0.9 No Hit N/A —
82 PA3477 transcriptional regulator RhlR PA3477, rhlR, vsmR, lasM Experimental + AlphaFold DB model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0001216A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. +1316 total
No map 0.899 No Hit N/A —
83 PA2888 geranyl-CoA carboxylase subunit beta PA2888, atuC Experimental + AlphaFold DB model –
GO:0047925Catalysis of the reaction: ATP + bicarbonate + geranoyl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + 2 H+ + phosphate. GO:0046247The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units. GO:0016874Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
No map 0.897 Hit 56.6% 1.07e-51
84 PA1010 4-hydroxy-tetrahydrodipicolinate synthase dapA, PA1010 Experimental + AlphaFold DB model
4.3.3.7
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008840Catalysis of the reaction: L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+. GO:0019877OBSOLETE. The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. +25 total
No map 0.897 Hit 29.3% 1.10e-28
85 PA3699 transcriptional regulator PA3699 Experimental + AlphaFold DB model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.894 No Hit N/A —
86 PA2020 transcriptional regulator ttgR, amrR, PA2020 Experimental + AlphaFold DB model –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0001217A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. +58 total
No map 0.894 No Hit N/A —
87 PA3345 hypothetical protein PA3345 Experimental + AlphaFold DB model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009927Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator. GO:0043424Binding to a protein histidine kinase. +47 total
No map 0.893 No Hit N/A —
88 PA2862 lactonizing lipase PA2862, lip, lipA Experimental + AlphaFold DB model
3.1.1.3
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0016298Catalysis of the hydrolysis of a lipid. GO:0046872Binding to a metal ion. +47 total
No map 0.893 No Hit N/A —
89 PA2392 pyoverdine biosynthesis protein PvdP PA2392, pvdP Experimental + AlphaFold DB model –
GO:0046872Binding to a metal ion. GO:0004503Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates. GO:0002049The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine.
No map 0.892 No Hit N/A —
90 PA4921 hypothetical protein PA4921, choE Experimental + AlphaFold DB model –
GO:0004104Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion. GO:0016788Catalysis of the hydrolysis of any ester bond.
No map 0.891 No Hit N/A —
91 PA0262 hypothetical protein PA0262, vgrG2b Experimental + AlphaFold DB model
3.4.24.-
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0033104A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +25 total
No map 0.891 No Hit N/A —
92 PA4017 hypothetical protein PA4017 Experimental + AlphaFold DB model – – No map 0.89 Hit 30.7% 1.24e-21
93 PA3528 ribonuclease T PA3528, rnt Experimental + AlphaFold DB model
3.1.13.-
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0000287Binding to a magnesium (Mg) ion. +69 total
No map 0.89 No Hit N/A —
94 PA4616 C4-dicarboxylate-binding protein PA4616 Experimental + AlphaFold DB model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0015740The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.888 No Hit N/A —
95 PA1349 hypothetical protein PA1349 Experimental + AlphaFold DB model – – No map 0.888 No Hit N/A —
96 PA0085 protein secretion apparatus assembly protein hcp1, PA0085 Experimental + AlphaFold DB model –
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0042802Binding to an identical protein or proteins.
No map 0.888 No Hit N/A —
97 PA3764 membrane-bound lytic murein transglycosylase F PA3764, mltF Experimental + AlphaFold DB model
4.2.2.n1
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0008933Catalysis of the cleavage of a peptidoglycan chain into a peptidoglycan chain with N-acetyl-1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end. Includes endolytic transglycosylase activity that fragments the glycan chain internally and exolytic transgylcosylase activity that cleaves a terminal disaccharide from the end of the glycan strand. GO:0016998The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. +58 total
No map 0.887 No Hit N/A —
98 PA4631 hypothetical protein PA4631 Experimental + AlphaFold DB model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004029Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH.
No map 0.885 No Hit N/A —
99 PA3908 hypothetical protein PA3908 Experimental + AlphaFold DB model – – No map 0.884 No Hit N/A —
100 PA1798 two-component sensor ParS parS, PA1798 Experimental + AlphaFold DB model
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. +47 total
No map 0.882 No Hit N/A —
Page of 29 · 701 total proteins