Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3501 PA1569 major facilitator superfamily transporter PA1569 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.669 Hit 36.0% 1.54e-12
3502 PA1171 transglycosylase PA1171 AlphaFold –
GO:0008933Catalysis of the cleavage of a peptidoglycan chain into a peptidoglycan chain with N-acetyl-1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end. Includes endolytic transglycosylase activity that fragments the glycan chain internally and exolytic transgylcosylase activity that cleaves a terminal disaccharide from the end of the glycan strand. GO:0009253The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0009254The continual breakdown and regeneration of peptidoglycan required to maintain the bacterial cell wall. Peptidoglycans consist of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides.
No map 0.669 No Hit N/A —
3503 PA1071 ABC transporter ATP-binding protein PA1071, braF AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +710 total
No map 0.669 Hit 30.5% 8.22e-18
3504 PA0923 DNA polymerase IV PA0923, dinB AlphaFold
2.7.7.7
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003684Binding to damaged DNA. GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. +58 total
No map 0.669 Hit 49.5% 9.50e-28
3505 PA0724 phage coat protein A PA0724 AlphaFold – – No map 0.669 No Hit N/A —
3506 PA0493 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit PA0493 AlphaFold –
GO:0009317A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. GO:0003989Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
No map 0.669 No Hit N/A —
3507 PA5525 transcriptional regulator PA5525 AlphaFold –
GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.668 No Hit N/A —
3508 PA5277 diaminopimelate decarboxylase PA5277, lysA AlphaFold
4.1.1.20
GO:0008836Catalysis of the reaction: meso-2,6-diaminopimelate + H+ = L-lysine + CO2. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. +14 total
No map 0.668 Hit 31.6% 4.39e-06
3509 PA5220 hypothetical protein PA5220 AlphaFold – – No map 0.668 No Hit N/A —
3510 PA5071 16S ribosomal RNA methyltransferase RsmE PA5071 AlphaFold
2.1.1.193
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0070042Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine. GO:0070475The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. +25 total
No map 0.668 No Hit N/A —
3511 PA4681 hypothetical protein PA4681 AlphaFold – – No map 0.668 No Hit N/A —
3512 PA4605 hypothetical protein PA4605 AlphaFold – – No map 0.668 No Hit N/A —
3513 PA4302 ATPase TadA tadA, PA4302 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.668 No Hit N/A —
3514 PA3767 hypothetical protein PA3767, tadA AlphaFold
3.5.4.33
GO:0052717Catalysis of the reaction: adenosine34 in tRNA + H2O + H+ = inosine34 in tRNA + NH4+. GO:0008270Binding to a zinc ion (Zn). GO:0002100The process in which an adenosine at position 34 of a tRNA is post-transcriptionally converted to inosine. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon. +36 total
No map 0.668 Hit 40.5% 2.46e-13
3515 PA2806 7-cyano-7-deazaguanine reductase PA2806, queF AlphaFold
1.7.1.13
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0033739Catalysis of the reaction: 7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-deazaguanine + 2 NADPH + 3 H+. GO:0008616The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in position 34 of tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon. +25 total
No map 0.668 No Hit N/A —
3516 PA2033 hypothetical protein PA2033 AlphaFold –
GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0052851Catalysis of the reaction: 2 a Fe(II)-siderophore + NADP+ + H+ = 2 a Fe(III)-siderophore + NADPH. GO:0010106Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions. +36 total
No map 0.668 No Hit N/A —
3517 PA0803 hypothetical protein PA0803 AlphaFold – – No map 0.668 No Hit N/A —
3518 PA5298 xanthine phosphoribosyltransferase PA5298, xpt AlphaFold
2.4.2.22
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000310Catalysis of the reaction: diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine. GO:0006166Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. +47 total
No map 0.667 No Hit N/A —
3519 PA4588 glutamate dehydrogenase gdhA, PA4588 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004354Catalysis of the reaction: L-glutamate + NADP+ + H2O = 2-oxoglutarate + NH4+ + NADPH + H+. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +47 total
No map 0.667 Hit 33.0% 8.78e-09
3520 PA3082 glycine betaine transmethylase gbt, PA3082 AlphaFold – – No map 0.667 No Hit N/A —
3521 PA2415 hypothetical protein PA2415 AlphaFold – – No map 0.667 No Hit N/A —
3522 PA1565 oxidoreductase PA1565 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006598The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups.
No map 0.667 No Hit N/A —
3523 PA1219 hypothetical protein PA1219 AlphaFold –
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
No map 0.667 No Hit N/A —
3524 PA0843 phospholipase C accessory protein PlcR plcR AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.667 No Hit N/A —
3525 PA0232 4-carboxymuconolactone decarboxylase PA0232, pcaC AlphaFold
4.1.1.44
GO:0047575Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H+ = 5-oxo-4,5-dihydro-2-furylacetate + CO2. GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
No map 0.667 No Hit N/A —
Page of 223 · 5572 total proteins