Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3551 PA2773 hypothetical protein PA2773 AlphaFold – – No map 0.664 No Hit N/A —
3552 PA2580 hypothetical protein PA2580 AlphaFold
1.6.5.10
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003955Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol. GO:0008753Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol. +14 total
No map 0.664 No Hit N/A —
3553 PA2463 hypothetical protein PA2463 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0098046A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc). GO:0008320Enables the transfer of a protein from one side of a membrane to the other. +25 total
No map 0.664 No Hit N/A —
3554 PA0866 aromatic amino acid transporter AroP PA0866, aroP2 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
No map 0.664 Hit 26.6% 1.19e-11
3555 PA5335 hypothetical protein PA5335 AlphaFold –
GO:0016891Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. GO:0006401The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
No map 0.663 No Hit N/A —
3556 PA4759 4-hydroxy-tetrahydrodipicolinate reductase PA4759, dapB Experimental + AlphaFold
1.17.1.8
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008839Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. +47 total
No map 0.663 No Hit N/A —
3557 PA4191 iron/ascorbate oxidoreductase PA4191 Experimental + AlphaFold
1.13.12.19 1.14.20.7
GO:0102276Catalysis of the reaction: 2-oxoglutarate(2-) + O2 + 2 H+ = ethene + 3 carbon dioxide + H2O. GO:0016706Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. GO:0046872Binding to a metal ion. +14 total
No map 0.663 No Hit N/A —
3558 PA2519 transcriptional regulator XylS PA2519, xylS AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
No map 0.663 No Hit N/A —
3559 PA0770 ribonuclease III rnc, PA0770 AlphaFold
3.1.26.3
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003725Binding to double-stranded RNA. GO:0046872Binding to a metal ion. +811 total
No map 0.663 Hit 35.3% 1.18e-10
3560 PA4866 hypothetical protein PA4866, pitA Experimental + AlphaFold
2.3.1.-
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.662 No Hit N/A —
3561 PA4374 resistance-nodulation-cell division (RND) efflux membrane fusion protein PA4374 AlphaFold –
GO:1990281A protein complex that is capable of efflux transmembrane transporter activity. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
No map 0.662 No Hit N/A —
3562 PA3620 DNA mismatch repair protein MutS PA3620, mutS AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140664A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis. +36 total
No map 0.662 Hit 56.4% 1.23e-08
3563 PA3249 transcriptional regulator PA3249 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.662 No Hit N/A —
3564 PA2953 electron transfer flavoprotein-ubiquinone oxidoreductase PA2953 AlphaFold
1.5.5.1
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0004174Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein]. GO:0046872Binding to a metal ion. +14 total
No map 0.662 Hit 65.2% 2.70e-29
3565 PA2053 carbonic anhydrase cynT, PA2053 AlphaFold
4.2.1.1
GO:0004089Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. GO:0008270Binding to a zinc ion (Zn). GO:0015976A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. +14 total
No map 0.662 No Hit N/A —
3566 PA0880 ring-cleaving dioxygenase PA0880 AlphaFold –
GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate.
No map 0.662 Hit 57.4% 7.51e-49
3567 PA5448 glycosyltransferase WbpY wbpY, PA5448 AlphaFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:0009243The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide.
No map 0.661 No Hit N/A —
3568 PA4699 hypothetical protein PA4699 Experimental + AlphaFold –
GO:0005515Binding to a protein.
No map 0.661 No Hit N/A —
3569 PA4329 pyruvate kinase PA4329, pykA Experimental + AlphaFold
2.7.1.40
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +69 total
No map 0.661 Hit 56.1% 1.48e-08
3570 PA2906 oxidoreductase PA2906 AlphaFold –
GO:0009337A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +47 total
No map 0.661 No Hit N/A —
3571 PA2891 geranyl-CoA carboxylase subunit alpha PA2891, atuF AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004075Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. GO:0047925Catalysis of the reaction: ATP + bicarbonate + geranoyl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + 2 H+ + phosphate. +25 total
No map 0.661 Hit 59.6% 2.72e-12
3572 PA2824 sensor/response regulator hybrid protein PA2824 AlphaFold
2.7.13.3
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. +47 total
No map 0.661 No Hit N/A —
3573 PA2792 hypothetical protein PA2792 AlphaFold – – No map 0.661 No Hit N/A —
3574 PA2395 pyoverdine biosynthesis protein PvdO pvdO, PA2395 Experimental + AlphaFold –
GO:0120147Catalysis of the reaction: A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O. GO:0046872Binding to a metal ion. GO:0002049The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine.
No map 0.661 Hit 29.3% 1.62e-19
3575 PA1574 hypothetical protein PA1574, ppnP Experimental + AlphaFold
2.4.2.1 2.4.2.2
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0047975Catalysis of the reaction: guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine. GO:0004731Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. +36 total
No map 0.661 No Hit N/A —
Page of 223 · 5572 total proteins