Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3576 PA0861 hypothetical protein PA0861 Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+. GO:0005525Binding to GTP, guanosine triphosphate. +36 total
0.661 No Hit N/A —
3577 PA0820 hypothetical protein PA0820 AlphaFold –
GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0003676Binding to a nucleic acid. GO:0008270Binding to a zinc ion (Zn).
0.661 No Hit N/A —
3578 PA0196 pyridine nucleotide transhydrogenase subunit beta pntB, PA0196 AlphaFold
7.1.1.1
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0008750Catalysis of the reaction: H+(in) + NAD+ + NADPH = H+(out) + NADH + NADP+. +36 total
0.661 Hit 47.4% 2.34e-131
3579 PA2607 hypothetical protein PA2607 AlphaFold –
GO:1990228A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor). GO:0002143The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.66 No Hit N/A —
3580 PA2146 hypothetical protein PA2146 AlphaFold – – 0.66 No Hit N/A —
3581 PA2111 hypothetical protein PA2111 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.66 No Hit N/A —
3582 PA1283 transcriptional regulator PA1283 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.66 No Hit N/A —
3583 PA1087 flagellar hook-associated protein FlgL flgL, PA1087 AlphaFold –
GO:0009424The portion of the bacterial-type flagellum that connects the filament to the basal body. GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0005198The action of a molecule that contributes to the structural integrity of a complex. +25 total
0.66 No Hit N/A —
3584 PA5089 hypothetical protein PA5089 AlphaFold –
GO:0004630A glycerophospholipase activity that cleaves the second phosphodiester bond between the phosphate and phospholipid, releasing a phosphatidic acid. GO:0009395The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.659 No Hit N/A —
3585 PA4431 iron-sulfur protein PA4431 AlphaFold
7.1.1.8
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion. +36 total
0.659 Hit 40.3% 2.66e-35
3586 PA4170 hypothetical protein PA4170 AlphaFold –
GO:0004791Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.659 No Hit N/A —
3587 PA2262 2-ketogluconate transporter PA2262, ttuB, kguT AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
0.659 Hit 26.1% 5.03e-16
3588 PA1296 2-hydroxyacid dehydrogenase PA1296 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0030267Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+. GO:0016618Catalysis of the reaction: (R)-glycerate + NAD(P)+ = 3-hydroxypyruvate + NAD(P)H + H+. +14 total
0.659 Hit 35.3% 2.58e-15
3589 PA1083 flagellar basal body L-ring protein PA1083, flgH AlphaFold –
GO:0009427One of the rings of the bacterial-type flagellar basal body; anchors the basal body to the outer membrane. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0003774Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). +14 total
0.659 No Hit N/A —
3590 PA0888 arginine/ornithine ABC transporter substrate-binding protein AotJ argT_2, PA0888, aotJ AlphaFold –
GO:0005615OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0016597Binding to an amino acid, organic acids containing one or more amino substituents. +25 total
0.659 No Hit N/A —
3591 PA4930 biosynthetic alanine racemase PA4930, alr Experimental + AlphaFold
5.1.1.1
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008784Catalysis of the reaction: L-alanine = D-alanine. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. +69 total
0.658 No Hit N/A —
3592 PA3193 glucokinase glk, PA3193 AlphaFold
2.7.1.2
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005536Binding to D-enantiomers of glucose. +36 total
0.658 No Hit N/A —
3593 PA2447 transcriptional regulator PA2447 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.658 No Hit N/A —
3594 PA1943 hypothetical protein PA1943 AlphaFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.658 Hit 25.6% 2.33e-06
3595 PA1093 hypothetical protein PA1093 AlphaFold – – 0.658 No Hit N/A —
3596 PA1069 hypothetical protein PA1069 AlphaFold –
GO:0005515Binding to a protein.
0.658 No Hit N/A —
3597 PA0891 hypothetical protein PA0891, aotO AlphaFold –
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0046872Binding to a metal ion.
0.658 No Hit N/A —
3598 PA0832 hypothetical protein PA0832 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004416Catalysis of the reaction: an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H+. GO:0046872Binding to a metal ion. +14 total
0.658 Hit 28.6% 1.46e-14
3599 PA0758 hypothetical protein PA0758 AlphaFold – – 0.658 No Hit N/A —
3600 PA0225 transcriptional regulator PA0225 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.658 No Hit N/A —
Page of 223 · 5572 total proteins